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Query: UMLS:C0016632 (Fox)
 1,461 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In 1964 Robin Holliday (1) proposed the correction of DNA base pair mismatches within recombination intermediates as the basis for gene conversion. The existence of the mismatch repair systems implied by this proposal is now well established. Activities that recognize and process base pairing errors within the DNA helix have been identified in bacteria, fungi, and mammalian cells. However, the functions and mechanisms of such systems are best understood in Escherichia coli, an organism that possesses at least three distinct mismatch correction pathways. These three systems are involved not only in the processing of recombination intermediates but also contribute in a major way to the genetic stability of the organism, a function anticipated for mismatch repair by Tiraby and Fox and by Wagner and Meselson. The significance of mismatch correction in the maintenance of low spontaneous mutability becomes apparent when one considers that seven E. coli mutator genes (dam, mutD, mutH, mutL, mutS, mutU, and mutY) have been implicated in mismatch repair. This minireview will summarize information on the most extensively studied E. coli system for mismatch correction, the methyl-directed pathway for processing of DNA biosynthetic errors and intermediates in genetic recombination. A discussion of other E. coli mismatch correction systems may be found in the recent literature and in several recent reviews. Mismatch repair pathways in other organisms and descriptions of the structural properties of mispaired bases may also be found in several of these reviews.
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PMID:Methyl-directed DNA mismatch correction. 265 30

On 21 July, Lord Soulsby of Swaffham Prior took office as President of the Royal Society of Medicine. He qualified mrcvs from Edinburgh in 1948 and held lectureships in Bristol and Cambridge before appointment as Professor of Parasitology in the University of Pennsylvania in 1964. There he stayed for fourteen years, returning to Cambridge in 1978 as Professor of Animal Pathology (now Emeritus). His work as a parasitologist has taken him to the USSR, Nigeria, India, Australia, South America, China and numerous countries of Europe. Earlier presidencies have included the Royal College of Veterinary Surgeons, the World Association for the Advancement of Parasitology, the Cambridge Society for Comparative Medicine, and the Comparative Medicine Section of the RSM (1993-95); he is Patron of the Fund for Replacement of Animals in Medical Experiments. He has been a consultant to international bodies including WHO, the UN Development Programme, FAO, and the International Atomic Energy Agency. Created a life peer in 1990 (now on the Opposition benches), he chaired a Select Committee on antibiotic resistance whose report appeared earlier this year. He is interviewed here by Robin Fox.
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PMID:A veterinary President. Interview by Robin Fox. 1032 86

By the late 1950s, Harry Frank Guggenheim was concerned with understanding why some charismatic leaders fought for freedom, while others sought power and domination. He believed that best-selling books on ethological approaches to animal and human behavior, especially those by playwright and screenwriter Robert Ardrey, promised a key to this dilemma, and he created a foundation that would fund research addressing problems of violence, aggression, and dominance. Under the directorship of Rutgers University professors Robin Fox and Lionel Tiger, the Harry Frank Guggenheim Foundation fostered scientific investigations into the biological basis of human nature. This essay analyzes their discussions of aggression as fundamental to the behavior of men in groups in order to elucidate the private and professional dimensions of masculine networks of US philanthropic and academic authority in the late 1960s and 1970s.
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PMID:Men in Groups: Anthropology and Aggression, 1965-84. 2706 19