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Query: UMLS:C0016632 (Fox)
 1,461 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A report of a myasthenia gravis-like syndrome, which occurred in two Fox Terrier litter mates, is presented. The clinical signs which appeared within 5 weeks of birth, and the subsequent course of the disease are described. Treatment with neostigmine and atropine initially provided control. Some recognised features of the condition in dogs are briefly reviewed.
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PMID:Myasthenia gravis in a Fox Terrier litter. 126 98

In 13 Smooth Fox Terriers with a congenital form of myasthenia gravis, clinical signs included intermittent, progressive muscle weakness that became more pronounced with exercise; muscle wasting; megaesophagus; and aspiration pneumonia. Neurologic abnormalities were apparent only during periods of weakness and included inability to retract the fore- and hindlimbs from painful stimuli. A decrement of the compound muscle action potential was evident during repetitive supramaximal nerve stimulation. Intravenous injection of a short-acting cholinesterase inhibitor evoked immediate improvement of clinical and electromyographic signs. Intracellular microelectrode studies of a biopsied external intercostal muscle revealed reduced amplitude of miniature end-plate potentials, as occurs in acquired myasthenia gravis. However, in contrast to acquired myasthenia gravis, antibodies directed against acetylcholine receptors were not demonstrable in serum and were not bound to acetylcholine receptors in muscle. Despite lack of complexing with immunoglobulin, the amount of acetylcholine receptor protein in biopsied external intercostal muscles from 9 affected pups was less than 25% of the amount in 5 unaffected littermates. The latter finding accounted for the reduction in amplitude of miniature end-plate potential and the failure of neuromuscular transmission. Treatment with a long-acting cholinesterase inhibitor in 6 cases resulted in temporary improvement in muscle strength.
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PMID:Congenital myasthenia gravis in 13 smooth fox terriers. 684 Dec 51

The authors describe various surgical treatments for ptosis due to mitochondrial myopathies and myasthenia gravis. Six patients out of ten underwent an anterior approach levator resection. Four out of ten were submitted to a brow suspension according to Fox's technique. Results and postoperative complications are examined and discussed.
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PMID:[Surgical treatment of ptosis in cases of mitochondrial myopathies and severe myasthenia]. 817 73