Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0016632 (Fox)
 1,461 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The structure of foot-and-mouth disease virus (FMDV) strain O1 BFS 1860 has been determined to 2.9 A resolution using the molecular-replacement method [Acharya, Fry, Stuart, Fox, Rowlands & Brown (1989). Nature (London), 337, 709-716]. Crystals of the virus with average dimensions 0.12 x 0.06 x 0.12 mm belong to space group I23, a = 345 A with 1/12 of the icosahedral particle per asymmetric unit giving fivefold noncrystallographic redundancy. Oscillation diffraction photographs were collected at the SERC Synchrotron Radiation Source at Daresbury in accordance with strict disease security regulations. The ambiguity in particle orientation was resolved using a self-rotation function and starting estimates of the phases to 8 A were derived from the known structures of two picornaviruses similarly oriented in the I23 unit cell. The phases were refined and extended using iterative averaging and solvent flattening with the implementation of a simple automatic envelope-determination procedure to increase the phasing power available.
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PMID:Methods used in the structure determination of foot-and-mouth disease virus. 838 28

Oral disease is common the housebound population ( Tomson et al, 2015 ). There can be a significant impact on the wellbeing of a housebound individuals ( Locker et al, 2000 ), who tend to be elderly, with poorer systemic health ( Qiu et al, 2010 ) and barriers to accessing care ( Freeman, 1999 ). Access to dental care can be limited (Fox, 2010) and prevention of oral disease is therefore paramount. Community nurses are in an excellent position to promote good oral care to the housebound patient and to support family in carers in preventing oral disease. This initial article in a series aims to provide information on common oral conditions with the next focusing on prevention and the role of nursing team.
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PMID:Part 1: Diagnosis of oral diseases in the housebound patient. 2792 76