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Query: UMLS:C0016632 (Fox)
 1,461 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Differences and similarities of the Bsp-repeats' organization in fox, dog, polar fox and raccoon dog genomes were studied. Specificity of Bsp-repeats to the Canidae family was demonstrated. The repeats are mainly organized in large clusters in all species studied. The species-specific features in restriction patterns were revealed for all five genomes, in spite of high intragenomic polymorphism exhibited in each case. This suggests that certain unique sets of structural versions of Bsp-repeats were fixed in canid genomes by amplification during the process of speciation. Fox and polar fox exhibited the highest similarity in restriction patterns of Bsp-repeats. Raccoon dog pattern is most unusual among others: its distinguishable character is the absence of large multimeric series. The EcoRI hydrolysate of raccoon dog Bsp-repeats consists mainly of one band corresponding to 1600 bp. These are in accordance with phylogenetic relations between canids.
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PMID:[Species-specific features of the distribution of restriction sites in Bsp-repeats of Canidae genome]. 177 37

The Cancer Information Service at the Fox Chase Cancer Center receives over 8,000 calls per year requesting referrals to local health care services. We developed a multi-user microcomputer-based system for entering, storing, updating and retrieving cancer referral resource information. Counselors use a menu-based system to retrieve referral resources by agency name, subject, state, county, city, telephone area code, zip code, or fee code. The system also includes menus for expediting database management: data entry, updating, browsing, and report generation. A data entry screen allows records to be entered or edited. The system can print mailing labels and update sheets for each agency. This system enhances our ability to disseminate high-quality information to the public.
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PMID:Fox Chase Cancer Center Referral Resource Directory. 180 48

In the third part of this series on issues in ward management facing charge nurses, Jane Fox explores the crucial role of the charge nurse as mentor. An ability to emphathise with the student and a willingness to facilitate his/her personal and professional growth are described as the most important elements in the successful execution of the role. However, there are also considerable responsibilities and pressures associated with mentorship which it would be foolish to ignore. The author presents a reflective framework for use in mentorship which emphasises the positive theory while recognising the negatives of experienced reality.
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PMID:Mentorship and the charge nurse. 182 19

This study examined visual comparison performance for 6-24-point random polygon stimuli (Cooper & Podgorny, 1976). Stimulus complexity effects decreased with practice, consistent with Bethell-Fox and Shepard (1988). A difficult discrimination context produced greater complexity effects than an easy discrimination context, consistent with Folk and Luce (1987). The difficult discrimination context also led to more stimulus-specific learning and diminished stimulus complexity effects. Increased stimulus learning resulted in continued skill acquisition, better transfer, and less performance disruption when the task context was equated for all Ss. It is argued that improvements in performance in a perceptual comparison task are not solely a function of the amount of practice provided in responding to particular stimuli. The context in which responses are elicited is equally important and must be accommodated in theories of skill acquisition.
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PMID:Stimulus complexity effects in visual comparisons: the effects of practice and learning context. 183 90

Genetic recombination of nonreplicating phage lambda-DNA, during infection of homoimmune lysogenic bacteria, was previously observed to be dramatically stimulated by prior uv irradiation of the phages, even when the Escherichia coli hosts lacked the major uv-photo-product excision-repair system (UvrABC). UvrABC-independent recombination of circular phage molecules depends on host MutHLS functions and on undermethylation of adenines at GATC sites in the phage DNA, and thus appears to be the result of "mismatch repair" of uv photoproducts. Recombinant frequencies pass through a relatively sharp maximum at 20 J/m2 and decrease at higher doses, whereas most plausible models for the process predict monotonic increases with dose, or a plateau at high uv doses. A uv-dose-dependent loss of biological activity (restriction) of all intracellular phage DNA was also observed previously. In order to provide a framework for testing possible explanations for the unusual recombinant-frequency vs uv-dose curve, a statistical model was constructed. This model includes probability terms for all possible one-exchange and two-exchange recombination processes, and incorporates the assumption that dimer recombinants are more susceptible to restriction than monomer parents (or recombinants), because of their larger target size. By adjustment of model parameters, particularly epsilon, the efficiency per photoproduct of initiation of a recombinational exchange, a theoretical dose-response curve that agreed well with experiment was obtained. The best fit corresponded to epsilon = 0.035, close to the previously observed restriction efficiency of 0.053. In the calculations, the value for h0, the average length of heteroduplex DNA, was taken to be 0.5 lambda units, i.e., about 25 kilobase pairs. This estimate for h0 was obtained here by analysis of the density distributions of the progeny of crosses between nonreplicating density-labeled lambda-phage chromosomes, published by others [M. S. Fox, C. S. Dudney and E. J. Sodergren (1979) Cold Spring Harbor Symposium on Quantitative Biology, Vo. 43, pp. 999-1007].
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PMID:A probabilistic model for genetic recombination of nonreplicating lambda-phage DNA, stimulated by "mismatch repair" of UV photoproducts. 183 59

When human peripheral blood lymphocytes (PBLs) from Epstein-Barr virus (EBV)-seropositive donors are injected intraperitoneally into SCID mice, EBV+ B cell tumors develop within weeks. A preliminary report (Mosier, D. E., R. J. Gulizia, S. M. Baird, D. D. Richman, D. B. Wilson, R. I. Fox, and T. J. Kipps, 1989. Blood. 74(Suppl. 1):52a) has suggested that such tumors resemble the EBV-positive malignancy, Burkitt's lymphoma. The present work shows that generally the human (hu) PBL-SCID tumors are distinct from Burkitt's lymphoma and instead resemble lymphoblastoid cell lines (LCLs) generated by EBV-infection of normal B cells in vitro in terms of: (a) their cell surface phenotype, with expression of B cell activation antigens and adhesion molecules, (b) normal karyotype, and (c) viral phenotype, with expression of all the transformation-associated EBV latent proteins and, in a minority of cells, productive cycle antigens. Indeed, in vitro-transformed LCLs also grow when inoculated into SCID mice, the frequency of tumor outgrowth correlating with the in vitro growth phenotype of the LCL which is itself determined by the identity of the transforming virus (i.e., type 1 or type 2 EBV). Histologically the PBL-derived hu-SCID tumors resemble the EBV+ large cell lymphomas that develop in immuno-suppressed patients and, like the human tumors, often present at multiple sites as individual monoclonal or oligoclonal foci. The remarkable efficiency of tumor development in the hu-SCID model suggests that lymphomagenesis involves direct outgrowth of EBV-transformed B cells without requirement for secondary genetic changes, and that selection on the basis of cell growth rate alone is sufficient to explain the monoclonal/oligoclonal nature of tumor foci. EBV+ large cell lymphoma of the immunosuppressed may arise in a similar way.
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PMID:Epstein-Barr virus (EBV)-associated lymphoproliferative disease in the SCID mouse model: implications for the pathogenesis of EBV-positive lymphomas in man. 184 72

The surgical corrective result of complete blepharoptosis is often uncertain. With suspension by Frontalis aponeurosis flap under the brow, the author treated 73 cases satisfactorily, the results conforming to Fox's criteria of a normal eyelid. The incision is made in the skin and Orbicularis oculi at the double-fold of the eyelid, and a muscle flap 2 cm wide is separated from under the Orbicularis oculi at the brow in the conjunction of Orbicularis oculi and Frontalis. The flap is fixed to the tarsus, and a strip of redundant skin 2-3 mm wide excised. The incision is closed with intermittent sutures.
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PMID:[Correction of complete blepharoptosis with suspension by Frontalis aponeurosis flap]. 186 Apr 2

We analyzed the CD and uv absorption spectra of 5S RNA from Escherichia coli using the method developed in the preceding paper. The analysis of spectra of 5S RNA at 20 degrees C in 0.1M NaClO4, 2.5 mM Na+ (phosphate), pH 7.0, and 0.5 mM MgSO4 gave 7 +/- 3.6 A.U base pairs, 25 +/- 3.6 G.C base pairs, and 7.5 +/- 3.6 G.U base pairs. Estimates of nearest neighbor base pairs were more consistent with the Pieler-Erdmann and the Gewirth-Moore secondary structure models than with the Fox-Woese or the Burns-Luoma-Marshall models. We also examined the structure of 5S RNA as a function of temperature. The melting profile exhibited two transitions--one at about 35 degrees C and one above 50 degrees C. Our spectral data showed that helices I and II were stable during the first transition, and agreed with other data that helix III was the most likely helix to have melted. The results from this in-depth study of 5S RNA indicate that our method of analysis should be useful for studying the secondary structures of other small, unmodified RNAs.
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PMID:An estimate of the nearest neighbor base-pair content of 5S RNA using CD and absorption spectroscopy. 186 90

The synthesis of a living system in the lab has been judged by a number of critics as partly attained by the proteinoid microsphere because of its primitive properties of metabolism, growth, and reproduction. These same critics, however, judge the organism as not alive, or as being 50 to 75 percent alive (Baltscheffsky and Jurka, 1984), owing to the absence of a nucleic acid genetic coding mechanism. The experiments in retracing evolution suggest, however, that the self-sequencing of amino acids was the evolutionary precursor of modern nucleic acid templating; the genetic memory is the molecule. The proteinoid microsphere is not a modern living system, but does represent at least a protoliving system (Fox and Dose, 1972). Berra (1990, p. 75) has commented on other difficulties in defining a protoliving system. In Berra's opinion, metabolism, reproduction, responsiveness to stimuli, and cellularity constitute or describe aliveness. These properties characterize proteinoid microspheres. A number of experiments demonstrate that amino acids in aminoacyl adenylates yield specific products, whereas nucleotides are without effect. For this and related reasons, especially the demonstrated self-sequencing of amino acids when they are warmed, resultant bio-functional properties of self-assembled microstructures, and demonstrated self-sequencing of amino acids in modern systems, the results appear to bridge from the chemical era to the biological period. All the above emerges from a departure in style of research (Young, 1984; Pauling and Zuckerkandl, 1972). The latter authors said, "It appears likely that biogenesis is the passage from a 'non-living system' existing in a large number of states to a 'living' system also existing in a large number of states."(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Synthesis of life in the lab? Defining a protoliving system. 189 92

The question of whether a feeding-tube could be withdrawn from Sidney Greenspan, a man who had survived in a Chicago nursing home for six years in a vegetative state, has focused ethical and legal deliberation on the issue of whether Illinois will follow the tradition of cases of court-sanctioned withdrawal (Quinlan, Fox, Conroy, Jobes, et al) or the more ambiguous precedents of Longeway and Cruzan, which disallowed withdrawal.
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PMID:The travail and triumph of Sidney Greenspan. 190 13


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