Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0016632 (Fox)
 1,461 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Dermatoses of the nipple and areola are rare. The commonest dermatosis is Paget's disease, which presents in the form of a well demarcated erythematous area, sometimes erosive, oozing or hyperkeratotic. Histological examination reveals an intraepidermal proliferation of large clear cells, either isolated or grouped in clumps, predominantly in the suprabasal layers. Immunohistochemistry shows that these cells express low molecular weight cytokeratins and the epithelial membrane antigen, fairly frequently carcinoembryonic antigen. In 96% of cases, Paget's disease is associated with underlying breast carcinoma, either in situ or invasive. Erosive adenomatosis presents in the form of an erosion of the nipple, which is sometimes increased in size. Histologically, it consists of a benign tumour which may ulcerate the epidermis, composed of tubes and papillae lined by a double layer of epithelial and myoepithelial cells. The syringomatous tumour is exceptional. In places, it forms rudimentary sweat ducts and is considered to have an intermediate malignancy; its resection must be complete. Other tumours may also be observed in this site: leiomyoma, leiomyosarcoma, benign cutaneous lymphocytoma, basal cell carcinoma, naevoid areolar hyperkeratosis. They are exceptional except areolar neurofibromas in case of neurofibromatosis. Infectious dermatoses (viral warts, molluscum contagiosum, scabies) are accompanied by lesions in other sites. They same applied to the majority of inflammatory dermatoses such as eczema or Fox-Fordyce disease. Supernumerary nipples are situated on a line extending from the anterior part of the axillary crease to the medial part of the inguinal crease.
 ...
PMID:[Dermatoses of the nipple and the areola]. 779 32

Atopic dermatitis has been described under many names before the XXth century, and first illustrated in the early XIXth century. This article presents historical images from the first volumes of Robert Willan to the Pratique dermatologique, the first encyclopedy published in 1900. Many accurate clinical descriptions of the disease can be found in the early treaties of dermatology, including the one published by Thomas Carrere in 1740. Since then, Alibert and Rayer in France, Hebra and Neumann in Vienna and Duhring and Fox in the USA illustrated their atlases with spectacular images of adults or children suffering from AD, or from other diseases that might have been considered as eczema infantile. Color engravings, color lithographs and black and white photographs showed with an increasing precision the semiology of AD, in the context of artistic representations of high quality, that have not been surpassed by modern photographs. At the beginning of the XXth century the clinical presentation, the course and heredity of the disease were perfectly established, introducing a new era of research in physiopathology and treatment in the following decades.
 ...
PMID:??? 2922 86