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Query: UMLS:C0016632 (Fox)
 1,461 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

People have many different reasons for wanting to know how the allogeneic relationship in normal human pregnancy is successful, but this question is far from being answered. Meanwhile, investigators will continue to use the ideas, approaches and tools with which they have experience and in which they have placed their confidence. Some study the factors which regulate immune functions in the fetus (for review see Murgita & Wigzel 1981); other focus more on the mother (for review see Rocklin et al. 1979); while yet others examine specialized aspects of abnormal pregnancies such as spontaneous abortion (Gill 1983). Although no one knows how the system operates to favor pregnancy, our particular bias is that trophoblast is the driving force which makes it work; for, without trophoblast, there is no pregnancy. This prejudice grew from our early observations of immunopathology in normal placentae (McCormick et al. 1971, Faulk et al. 1974, Faulk et al. 1980b, and reviewed by Faulk & Fox 1982) and was extended and amplified by experiments which showed that trophoblast, as well as antibodies to trophoblast, were able to impede allogeneic recognition as measured by specific inhibition of the mixed lymphocyte culture reaction (McIntyre & Faulk 1979 & 1979a). For a variety of reasons, many laboratories became interested in trophoblast-antigen biochemistry, and a burst of publications appeared on this subject (Faulk et al. 1977, Whyte & Loke 1979, Ogbimi et al. 1979, see review by Johnson et al. 1980). Some of this work confirmed and extended an earlier hypothesis from our laboratory that trophoblast membranes could serve as a hapten-carrier system where one group of trophoblast antigens (TA1) was the carrier, and a second group (TA2) was the hapten (Faulk et al. 1978). This hypothesis invoked a concept of trophoblast-lymphocyte cross-reactive antigens, an idea which was subsequently confirmed biochemically by showing human placental cell-surface antigens on peripheral blood lymphocytes (Hamilton et al. 1980). McIntyre and Faulk (1982, 1982a) later showed that these antigens were allotypic, and data have been provided in the above paragraphs to show that these components of trophoblast membranes are capable of serving as immunogens to stimulate the mother to mount immune recognition of her blastocyst. Indeed, it is presently our interpretation that successful nidation depends upon maternal recognition of the blastocyst, and that a lack of recognition results in spontaneous abortion, sometimes occurring so early that the mother is not aware that she was pregnant (Miller et al. 1980).(ABSTRACT TRUNCATED AT 400 WORDS)
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PMID:Immunological studies of human trophoblast: markers, subsets and functions. 635 11

A conference was held at the State University of New York at Stony Brook in October 1984 to discuss the controversy concerning treatment of a newborn with severe congenital defects that became known as the Baby Jane Doe case. Fox provides some background information on the case to introduce a set of of six articles consisting of papers delivered at the conference. These articles deal with historical aspects of the treatment debate (Stanley J. Reiser), problems of clinical decision making (John M. Freeman), the legal issues involved (John A. Robertson), coverage of the case by the media (Stephen Klaidman and Tom L. Beauchamp), federal efforts to regulate the treatment of handicapped newborns (Lawrence D. Brown), and the alliance that arose between opponents of abortion and advocates of the rights of the handicapped (Constance Paige and Elisa B. Karnofsky).
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PMID:Introduction to the Baby Jane Doe papers. 1164 30

Due to the genetic determination of susceptibility to scrapie and other forms of transmissible spongiform encephalopathy (TSE) in sheep breeding to the less susceptible prion protein (PrP) genotype ARR/ARR was advanced within EU. In 4961 ewes of nine German sheep breeds (Coburg Fox sheep, Gray Horned Heath sheep, Merinoland sheep, Rhoen sheep, German Blackheaded Mutton sheep, Shropshire, Suffolk, Texel and White East Friesian Milk sheep) representing local and cosmopolitan breeds the reproductive traits number of lambs born, dead (including abortion at the end of pregnancy, stillbirth and death during the first 56 days post natum), weaned and rearing rate at each lambing were recorded and in 1641 of these ewes the PrP genotype was determined. A linear model was used to evaluate associations between PrP genotype and reproduction traits including the effects of PrP genotype (four classes: ewes with two, one and no copy of the ARR allele and with unknown PrP genotype), breed, interaction of PrP genotype and breed, number of lambing, lambing season and stock. Significant associations were only observed between the PrP genotype and the number of dead lambs at each lambing in Shropshire and Merinoland sheep and the rearing rate at each lambing in Shropshire. These significant associations were mainly caused by differences between animals with unknown PrP genotype and animals of the other PrP classes. In conclusion, breeding for TSE resistant sheep will not lead to a reduction in economically important reproduction traits.
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PMID:Analysis of prion protein genotypes in relation to reproduction traits in local and cosmopolitan German sheep breeds. 1720 79

As Professor Dov Fox points out in his essay, reference to "potential life" in American abortion jurisprudence is both indeterminate and underspecified. This commentary highlights that use of the phrase "potential life" by courts also obscures the fact that a position has been taken that biological life is not the equivalent of legal personhood. Worse, the position has been imposed on those who do not share it without offering reasons to justify its imposition in terms that those who oppose it can reasonably be expected to endorse.
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PMID:Membership Has Its Privileges? Life, Personhood, and Potential in Discussions about Reproductive Choice. 2624 57