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Query: UMLS:C0016632 (Fox)
 1,461 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Mass vaccination of the juvenile population with live poliovirus vaccine was carried out in Poland in 1959 and 1960. In all, some 7 239 000 children 6 months to 14 years old were given type 1 (CHAT) virus, and nearly 6 818 500 children of the same age-group received type 3 (W-Fox) virus.A serological conversion rate (from <1:4 to >/=1:4) of 91.7% was achieved with type 1 and of 91.0% with type 3-a satisfactory demonstration of the immunogenicity of the strains used. Although type 2 virus was not administered, seroconversion with this type occurred in 65.4%. This may have been caused by antigenic elements common to the three poliovirus types, and previous vaccination with Salk vaccine may also have been a contributory factor.The authors conclude that the mass vaccination described in this paper has created a highly immune population in Poland.
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PMID:Vaccination against poliomyelitis in Poland with types 1 and 3 attenuated viruses of Koprowski. 1. Virological studies of the vaccine strains and serological studies of the vaccinated population. 1448 69

Mass oral vaccination of children against poliomyelitis was carried out in Poland in 1959 and 1960 with type 1 (CHAT strain) and type 3 (W-Fox) attenuated polioviruses. Altogether some 7 239 000 children 6 months through 14 years old received type 1 by May 1960 and nearly 6 818 500 children were fed type 3.Epidemiological observations indicate that the CHAT strain may safely be administered but that the W-Fox strain requires further investigation into the conditions in which it may be used for mass prophylaxis.The incidence of poliomyelitis in Poland decreased very considerably in 1960, the total incidence for that year (0.9 per 100 000) being almost 9 times lower than the median for the years 1951-59. Moreover, the usual summer-autumn epidemic outbreak did not occur in 1960.The efficacy of the vaccine (as calculated from the incidence of paralytic poliomyelitis among the vaccinated and among the unvaccinated) was evaluated at 86%.
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PMID:Vaccination against poliomyelitis in Poland with types 1 and 3 attenuated viruses of Koprowski: 2. Epidemiological evaluation of results of mass vaccination, 1959-60. 2060 15

The incidence of poliomyelitis in the People's Republic of Croatia has progressively increased since 1945, and in 1953 and 1960 there were serious epidemics. In order to protect the age-groups at greatest risk a mass vaccination campaign was carried out with Koprowski live-virus vaccine in the early spring of 1961, covering the entire population aged 3 months to 20 years. Altogether 1 339 244 persons were given type 1 (CHAT strain), and 1 287 909 received type 3 (W-Fox). Over 100 000 persons were estimated to possess no pre-existing antibody to any of the three types of poliovirus.Although no unvaccinated control group was set up, it is considered that the epidemiological and serological data indicate the safety and efficacy of the vaccination. The serological conversion rate was 91.5% for type 1 and 93.5% for type 3. No post-vaccinal reactions were observed. The usual summer peak in incidence did not occur in 1961, altogether 6 cases being recorded from June (when immunity is considered to have been established) to December. This is the lowest figure since 1945.
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PMID:Preliminary report on vaccination in Croatia against poliomyelitis with type 1 (CHAT) and type 3 (W-Fox) attenuated polioviruses of Koprowski. 2060 39