Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0016382 (
flushing
)
6,387
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The majority of pregnancy loss in ruminants occurs during the preimplantation stage, which is thus the most critical period determining reproductive success. Here, we performed a comparative transcriptome study by sequencing total mRNA from
corpus luteum
(CL) collected during the preimplantation stage of pregnancy in Finnsheep, Texel and F1 crosses. A total of 21,287 genes were expressed in our data. Highly expressed autosomal genes in the CL were associated with biological processes such as progesterone formation (
STAR
,
CYP11A1
, and
HSD3B1
) and embryo implantation (e.g.,
TIMP1
,
TIMP2
and
TCTP
). Among the list of differentially expressed genes, sialic acid-binding immunoglobulin (Ig)-like lectins (
SIGLEC3
,
SIGLEC14
,
SIGLEC8
), ribosomal proteins (
RPL17,
RPL34
, RPS3A
,
MRPS33
) and chemokines (
CCL5
, CCL24,
CXCL13
,
CXCL9
) were upregulated in Finnsheep, while four multidrug resistance-associated proteins (MRPs) were upregulated in Texel ewes. A total of 17 known genes and two uncharacterized non-coding RNAs (ncRNAs) were differentially expressed in breed-wise comparisons owing to the
flushing
diet effect. The significantly upregulated
TXNL1
gene indicated potential for embryonic diapause in Finnsheep and F1. Moreover, we report, for the first time in any species, several genes that are active in the CL during early pregnancy (including
TXNL1
,
SIGLEC14
,
SIGLEC8
,
MRP4,
and
CA5A
).
...
PMID:Gene Expression Profiling of
Corpus luteum
Reveals Important Insights about Early Pregnancy in Domestic Sheep. 3229 Mar 41
