Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0016382 (
flushing
)
6,387
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
G protein-coupled receptor 43
(
GPR43
) has been identified as a receptor for short-chain fatty acids that include acetate and propionate. A potential involvement of
GPR43
in immune and inflammatory response has been previously suggested because its expression is highly enriched in immune cells.
GPR43
is also expressed in a number of other tissues including adipocytes; however, the functional consequences of
GPR43
activation in these other tissues are not clear. In this report, we focus on the potential functions of
GPR43
in adipocytes. We show that adipocytes treated with
GPR43
natural ligands, acetate and propionate, exhibit a reduction in lipolytic activity. This inhibition of lipolysis is the result of
GPR43
activation, because this effect is abolished in adipocytes isolated from
GPR43
knockout animals. In a mouse in vivo model, we show that the activation of
GPR43
by acetate results in the reduction in plasma free fatty acid levels without inducing the
flushing
side effect that has been observed by the activation of nicotinic acid receptor, GPR109A. These results suggest a potential role for
GPR43
in regulating plasma lipid profiles and perhaps aspects of metabolic syndrome.
...
PMID:Activation of G protein-coupled receptor 43 in adipocytes leads to inhibition of lipolysis and suppression of plasma free fatty acids. 1849 55
