Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0016382 (flushing)
 6,387 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Donor exposure can be strikingly reduced for patients with classical hemophilia A and von Willebrand's disease when large volumes of potent cryoprecipitated AHF are prepared from donors following DDAVP (1-deamino-8-D-arginine vasopressin) stimulation and automated plasmapheresis--a procedure called "plasma exchange donation." Although this procedure has been reported to be relatively safe for donors, data are limited. Accordingly, we studied 20 donors during 48 procedures using DDAVP (0.3 micrograms/kg IV) followed by 2-3 L plasma collection. Replacement fluid for each initial plasma exchange donation was plasma protein fraction; autologous cryoprecipitate-poor plasma was used for subsequent procedures. Mild reactions, particularly facial flushing, were noted in all 48 procedures. No procedure was discontinued, but four were modified due to either an increased pulse rate (> or = 20/min from baseline) or a fall in systolic or diastolic blood pressure (> or = 20 mm Hg from baseline). No donor was deferred or withdrew from the program. Based on our modest experience, DDAVP stimulated plasma exchange donation appears to be a safe and effective method for collecting large quantities of plasma from which potent cryoprecipitated AHF can be prepared.
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PMID:Donor reactions during DDAVP-stimulated plasmapheresis. 142 92

In the last 10 years 63 courses (283 infusions) of porcine FVIII were given to 25 hemophiliacs with high titer alloantibodies and to 5 patients with autoantibodies to factor VIII. Although the product was in general clinically efficacious, adverse effects of treatment were more frequent and severe than previously reported. After 63 courses there was a median percentage fall in baseline platelet count of 54% (range 8-86%); for 10 courses (16%), thrombocytopenia was severe or moderately severe (less than 100 x 10(9)/l), with nadirs of platelet count ranging from 10 to 99 x 10(9)/l (median 67). Allergic reactions were seen in 15 of 30 patients (50%), in 20 of 63 courses (32%), more frequently but not exclusively after the first infusion. Relatively mild symptoms (fever, flushing, urticaria, shivering) occurred in 15 courses; 5 courses, however, were accompanied by more severe anaphylactoid reactions, 2 of which required resuscitation therapy. Allergic reactions were observed both in patients pretreated with steroids or anti-histamines (in 7 of 18 courses, 39%) and in nonpretreated patients (in 13 of 45 courses, 29%). In conclusion, adverse reactions are frequent after porcine FVIII (in 30 of 63 courses, 47%), and can occur also with infusions subsequent to the first. Hence, the recently proposed use of porcine FVIII as home treatment should be implemented with caution.
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PMID:Adverse effects of treatment with porcine factor VIII. 190 52

Some data on the synthesis and characterization of poly(HEMA-MAC) and its applications for fertility control are presented. This new technique involves the use of the polymer, which when injected into the vas deferens lowers the pH sufficiently so as to kill the spermatozoa passing through. The polymer provides an acidic environment for a prolonged time and slowly erodes. The fertility may be restored after complete solubility of the polymer itself over a period of time or by flushing it with a suitable solvent. It is a nonsurgical, nonocclusive, and reversible method of male contraception. In regard to the experimental procedure, copolymerization of HEMA with MAC (35% by weight) in methanol was carried out in a nitrogen atmosphere in glass ampules. Irradiation was performed in a cobalt-60 radiation chamber. All the samples were irradiated at a dose rate of 130 rad/s for a total dose of 0.936 Mrad at room temperature. For studying the spermicidal actions of the copolymer, epididymal fluid from the male rat was collected, diluted 1:10 with Ringer-fructose buffer and microscopically examined. Small swollen pieces of poly(HEMA-MAC) copolymer as well as poly(HEMA) homopolymer were then added to the epididymal fluid and the effect on the spermatozoa was noted. The spermicidal action "in vitro" was indicated by the loss of motility of the spermatozoa immediately on coming in contact with the poly(HEMA-MAC). The spermatozoa remained immotile even after the removal of the copolymer, indicating that they were dead. The polymer treated spermatozoa did not take up any supravital stain confirming that they were killed. This effect was absent only when poly(HEMA) was used. These results clearly show that the spermicidal activity is mainly due to the carboxylic groups of MAC. Possibly the low pH environment due to the ionization of carboxylic groups is responsible for killing the spermatozoa. For all the experiments the injection of the polymeric solution into the vas deferens was given only by exposing the vas deferens, but it is reported that in humans injection into the scrotal wall is possible. The new technique has all the characteristics which can lead to an ideal contraceptive method. Preliminary results of "in vitro" experiments on human spermatozoa with these hydrogels are encouraging.
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PMID:Novel mode of contraception using polymeric hydrogels. I. 705 60