Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0016382 (flushing)
 6,387 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Among 1,500 patients treated with extracorporeal shock wave lithotripsy, 1,300 had calculi less than 2.5 cm in diameter and 200 had calculi of 2.5 cm or larger. Although most patients did well and required no further radiologic intervention, 178 interventional radiologic procedures were performed. Urinary tract obstruction often developed in patients with large stones when the collecting system filled with stone fragments (steinstrasse). Nephrostomy was performed in 5.3% of the total patient population and in 29% of the patients with stones measuring 2.5 cm or more. Only 1.8% of the patients with calculi smaller than 2.5 cm required radiologic intervention. When the obstructed collecting system could not be crossed with conventional angiographic techniques, the stone fragments were removed through a percutaneous nephrostomy tract either by flushing or by suctioning with a pulsating water jet.
Radiology 1986 Dec
PMID:Extracorporeal shock wave lithotripsy: interventional radiologic solutions to associated problems. 378 4

Significant increment of blood-borne ovarian steroids are found in the uterine lumen 1 h after mating. Is the transfer of ovarian steroids into the uterus determined by the peripheral blood concentrations of the ovarian steroids? To answer this question, rabbits, ovariectomized 24 h earlier, were infused over a 1-h period with either estradiol (E2; 0.7 and 7.0 micrograms/h), progesterone (P4; 74 and 740 micrograms/h), or testosterone (T; 0.45 and 4.5 micrograms/h). E2, P4, and T were determined in the tissue and flushings of the uterus and tissue and flushings of the esophagus and plasma. A different group of rabbits was infused with E2 (0.7 micrograms), P4 (74 micrograms), and T (0.45 microgram/h) combined. The increase in plasma steroid concentration after infusion of either E2, P4, or T was reflected in an elevation of these steroids in the uterine lumen, albeit not in the same ratios as found in plasma. The simultaneous infusion of E2, P4, and T blocked completely the passage of T and decreased (P less than 0.05) the passage of E2 into the lumen of the uterus. Treatments did not affect the steroid concentration in the wall of the uterus. It was concluded that the content of E2, P4, or T in the uterine flushing increased when E2, P4, or T was infused individually. However, when these steroids were infused together, there was selective inhibition of the transfer process.
Am J Physiol 1986 Dec
PMID:Effect of plasma concentrations of ovarian steroids on their passage into uterine lumen in rabbits. 378 35

Breast milk antibodies have been shown to persist in the mouths of neonates for some hours following feeding. The decrease in concentration following a feed probably reflects the flushing action of salivary flow combined with swallowing.
Early Hum Dev 1986 Dec
PMID:Persistence of IgA in neonatal saliva following breast feeding. 380 73

Evidence is reviewed linking clinical effects of ethanol with actions on the sympathetic and parasympathetic nervous systems. The studies reported include a series of investigations by the authors. Acutely, ethanol causes peripheral vasodilation and may also result in changes in heart rate and blood pressure. Ethanol may contribute to acute problems which may present clinically, including micturition syncope, accidental hypothermia and facial flushing. However, increased sympathetic nervous activity plays a role in causing hypertension and other symptoms during ethanol withdrawal in chronic alcoholics. Some chronic alcoholics may have neuropathy involving sympathetic nerves, and this can result in distal sweating loss and occasionally in orthostatic hypotension. Also, hypothalamic lesions associated with Wernicke's encephalopathy may result in hypothermia. Neuropathy involving parasympathetic nerves in not uncommon in alcoholics with other evidence of nervous system damage, but it is generally asymptomatic. Occasionally, vagal neuropathy may cause disorder of gastrointestinal motility, and neuropathy affecting the sacral innervation may be a factor in alcoholic impotence.
Drug Alcohol Depend 1986 Dec
PMID:The effects of acute and chronic ingestion of ethanol on the autonomic nervous system. 381 27

Two cases of hypersensitivity reactions following etoposide infusion are reported, occurring in patients not previously exposed to the drug. In both cases, bronchospasm and diffuse skin flushing were the associated clinical findings. The present experience does not confirm the previous report by O'Dwyer and Weiss, who inferred the existence of two distinct clinical patterns in such patients, with either bronchospasm or flush. Type I hypersensitivity must be regarded as a possible acute adverse effect of etoposide infusion therapy, but more research seems necessary to elucidate the pathophysiology of this phenomenon.
Chemioterapia 1985 Dec
PMID:Etoposide-induced hypersensitivity reactions. Report of two cases. 383 Apr 14

The occurrence of legionella in the hot water systems of two buildings (A and B) was investigated in relation to the water temperature. The peripheral parts of both hot water systems were found to be colonized by these organisms. A temperature of 60 degrees C in the hot water mains returning from the building eliminated legionellas from the mains as well as from the peripheral taps and showers. Legionellas could be isolated from taps, showers and the mains when the temperature in the return mains was kept at 54 degrees C. The hot water systems could not be completely decontaminated by raising the hot water temperature in the return mains to 70 degrees C combined with flushing all the taps and showers. It is suggested that failure to decontaminate the systems is due to dead ends in the pipeline network, which are not reached by the hot water and that these dead ends are the source for recolonization of the systems.
J Appl Bacteriol 1985 Dec
PMID:Influence of temperature on the number of Legionella pneumophila in hot water systems. 383 Oct 4

Graft sensitization was measured in dogs receiving autotransplants of perfused, flushed or hypothermically preserved kidneys. Five kidney treatments were studied: (1) continuous pulsatile perfusion with Ross solution for 24 h; (2) flush with Ross solution followed by 24h cold storage; (3) removal and immediate reimplantation; (4) flush with Ross solution and immediate reimplantation; (5) cool and immediate reimplantation. Continuous perfusion resulted in a lower mean creatinine (measured over the first five days after transplant) than did flushing followed by cold storage (P less than 0.001). Creatinines were lower in the groups in which kidneys were not stored (regardless of treatment) than in the stored groups (P less than 0.001). Dogs were said to be immune if their leucocytes were inhibited by nephrectomy kidney antigen in the leucocyte migration inhibition assay [LMI]. Immune dogs had a higher mean creatinine than non-immune animals (P less than 0.05). All autografts were examined for deposition of IgG, IgM and C3 at post-mortem by tissue immunofluorescence [IF]. Positive immune responses (LMI or IF) were seen more often in dogs receiving long preserved grafts than in those receiving immediate graft implantation (P less than 0.05).
Br J Exp Pathol 1985 Dec
PMID:Immune response to storage-induced injury in non-ischaemic renal autografts. 391 75

Abuse of alcohol (ethanol) and abuse of an increasing number of drugs (e.g. analgesics and sedatives) are among the outstanding social and medical problems of many industrialized countries including Switzerland. Since alcohol consumption has profound effects on both the pharmacokinetic and pharmacodynamic actions of a variety of drugs, the rational use of drugs in alcoholics is an increasingly difficult task and requires a thorough understanding of the physiologic, biochemical, pharmacologic and toxic actions of alcohol. Clinically the most important targets of alcohol action are the liver and the central nervous system (CNS), both of which are frequently involved in the mediation of potentially fatal interactions between drugs and alcohol. In practice the most important of these interactions include (a) inhibition of hepatic (cytochrome P450 dependent) drug oxidation by acute alcohol ingestion resulting in increased bioavailability of drugs that are predominantly excreted by hepatic metabolism, (b) inhibition of acetaldehydedehydrogenase by some drugs with production of an acute flushing reaction to alcohol, (c) increased sensitivity of the CNS to a variety of sedative drugs following acute alcohol ingestion leading to enhanced CNS toxicity of most psychoactive drugs, (d) stimulation of hepatic drug oxidation and decreased CNS sensitivity to sedatives after chronic alcohol abuse, thus explaining the "metabolic" and pharmacodynamic tolerance of these patients towards psychoactive agents, and (e) depressed drug metabolism and increased CNS sensitivity to sedative and hypnotic drugs in patients with cirrhosis of the liver. The mechanisms and practical consequences of the clinically most important influences of acute and chronic alcohol ingestion on the pharmacokinetics and the pharmacodynamic actions of drugs are outlined.
Schweiz Med Wochenschr 1985 Dec 14
PMID:[Alcohol, alcoholism and drugs]. 391 83

A technique for oocyte collection by percutaneous puncture guided by ultrasound is described. The equipment includes a sector scanner with a puncture transducer. A coarse needle (16 gauge) and a syringe constitute the aspiration device. The syringe provides the vacuum and serves as a trap for the follicular fluids. Follicular flushing is performed by syringes containing culture medium. The aspiration is carried out as an out-patient procedure under local anaesthesia after premedication. The spontaneously filled bladder acts as an ultrasonic window and the needle is introduced through the bladder into the ovarian follicles, guided by the screen display. The oocyte recovery rate per follicle exceeds 80% with experience, and the collection can be performed in women with abundant pelvic adhesions. The only complication to the procedure is a short-lasting haematuria, observed in 5% of the cases.
Clin Obstet Gynaecol 1985 Dec
PMID:Percutaneous oocyte recovery using ultrasound. 391 83

Calcitonin gene-related peptide (CGRP) has been localized in cardiac nerve fibers and blood vessels from which it may be released as neurotransmitter or neuromodulator. Acute cardiovascular effects of i.v. administered CGRP have been studied in human subjects. CGRP (25.3 nmol) caused a mean maximal increase of the heart rate of 41 beats per min (P less than 0.01) and lowered arterial systolic and diastolic pressures by 26 mm Hg and 20 mm Hg, respectively (P less than 0.01) (n = 6 subjects). These effects were associated with facial flushing, and a rise of plasma levels of norepinephrine and epinephrine of 257 pg/ml and 9 pg/ml, respectively (P less than 0.01). Administration of equimolar amounts of human calcitonin caused no cardiovascular effects except for minor facial flushing. Serum calcium was marginally lowered with both CGRP (0.2 mg/100 ml) and calcitonin (0.4 mg/100 ml) (P less than 0.05). Furthermore, CGRP (12.7 nmol) reduced the preejection period and duration of the electromechanical systole by 26 msec and 66 msec, respectively (P less than 0.001 and P less than 0.01), presumably acting as positive inotropic agent. Labetalol, blocking adrenergic receptors, obliterated these inotropic effects, whereas the positive chronotropic and hypotensive actions of CGRP remained unchanged.
Calcif Tissue Int 1985 Dec
PMID:Cardiovascular action of calcitonin gene-related peptide in humans. 393 76


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