Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0016382 (flushing)
 6,387 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

High alcohol sensitivity among Asians is mainly due to a genetic polymorphism in the low Km aldehyde dehydrogenase (ALDH2) gene. Strong correlations between the ALDH2 genotype and alcohol sensitivity or alcohol drinking habits have been reported. Another prevalent polymorphism in the alcohol dehydrogenase beta-subunit (ADH2 gene) among Asians appears to modify skin flushing reactions after exposure to ethanol but does not influence alcohol drinking behavior. Both the ADH2 and ALDH2 genotypes have been significantly correlated with the risk of alcoholism. In a Japanese occupational population, a gene-environment interaction of the ALDH2 genotype and daily hassles scores for development of problem drinking behavior was observed. Habitual drinkers with the ALDH2*1/*2 genotype had higher frequencies of sister-chromatid exchange in cultured lymphocytes and higher 8-OHdG levels in polymorphonuclear leukocytes than those with the ALDH2*1/*1 genotype. Alcoholics and heavy drinkers with the ALDH2*1/*2 genotype have been shown to have significantly elevated risks for esophageal and multiple cancers in upper digestive organs than those with the ALDH2*1/*1 genotype. In Japan, bronchial asthma patients with the ALDH2*1/*2 genotype have been shown to have a significantly elevated risk for experiencing alcohol-induced asthma compared with the ALDH2*1/*1 genotype. Providing services to determine these genotypes would be of great help for each individual to make a plan for tailor-made health promotion.
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PMID:[Gene-environmental interactions in alcohol-related health problems--contributions of molecular biology to behavior modifications]. 1280 63

The article covers data on oxidative activity in cellular DNA, on cytogenetic effects, on sexual hormones levels under exposure to chemical hazards in female workers of dyeboard fabric preparation industry. Findings are that in such occupations as bleacher, mercerization and glazing operator, chemical solutions and dyes. supplier, flushing equipment operator demonstrate the highest serum levels of manganese, lead, toluene and xylene vs. the reference group parameters (1.5-1.8 times) due to occupational hazards. Significant differences were seen between the groups of exposed and unexposed workers in parameters characterizing negative effects development: higher activity of DNA oxidation products formation (according to increased urinary level of 8-OHdG), higher prevalence and variability of chromosomal polymorphism characterizing genetic instability of somatic cells, disbalance of sexual hormones (according to increased serum prolactine and lower FSH). These processes can result in functional disorders of pelvic organs, with increased prevalence of hormone-dependent gynecologic diseases in the female workers and remote effects in the offspring.
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PMID:[Evaluating cytogenetic and hormonal state in female workers of dyeboard industry of fabric preparation]. 2585 78