Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0016382 (flushing)
 6,387 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The most important problem during FBS examination in infants is respiratory care. A new ventilation method using the channel of the FBS is proposed for respiratory care during FBS examination in infants. An FBS with a channel of more than 1.2 mm in diameter was directly inserted into the trachea under general anaesthesia without an orotracheal tube. The first step of this ventilation is the flushing of pure O2 into the lung as inspiration through the channel of the FBS. The second step is the aspiration of expiratory gas through the channel by a vacuum pump. Ventilation during the FBS examination is maintained by the repetition of these two steps by the operation of a stop-cock. Experiments in dogs, and clinical use showed that this method of respiratory care is effective and safe with certain limitations. Clinically, inspection with the FBS could be performed continuously for five minutes in most cases.
Endoscopy 1984 Sep
PMID:Trans-FBS-channel ventilation during the flexible bronchoscope (FBS) examination in infant. 648 72

A simple and rapid high-performance liquid chromatographic method for determining eight common anti-epileptic drugs and metabolites in serum is described. A column-switching system including one analytical column and two precolumns for sample enrichment offers the possibility of directly injecting patients' sera without any pretreatment. The two precolumns are alternately switched over to avoid time loss in analysis due to the sample washing step. The samples are flushed with dilute phosphoric acid, as the purge liquid, onto the precolumns which consist of very short cartridges (length 0.5 cm) filled with spherical ODS silica gel (particle size 30 micron). The retained substances are carried over, after purification, onto the analytical column in the same direction of flow as in the flushing step. A mixture of acetonitrile and phosphoric acid--sodium phosphate buffer solution is thereby used as solvent for the gradient elution. The separation was carried out using an analytical column, which was filled with ODS material of particle size 5 micron.
J Chromatogr 1984 Sep 14
PMID:Routine determination of eight common anti-epileptic drugs and metabolites by high-performance liquid chromatography using a column-switching system for direct injection of serum samples. 650 25

Nine patients with mid-gut carcinoid tumours received leucocyte interferon (IFN) i.m. daily for 90 days. Six patients clearly ameliorated in symptoms typical of the carcinoid syndrome (flushing, diarrhoea, asthma) which correlated with reduced serum levels of tumour related polypeptides and urinary output of 5-hydroxyindole acetic acid (5-HIAA). Before IFN treatment, peripheral blood mononuclear leucocytes (PBLs) from carcinoid patients showed markedly deficient production of pH 2 labile IFN-alpha in response to Staphylococcus aureus Cowan I (SACoI) in vitro. In contrast, IFN-alpha responses to the inducers Sendai virus and beta-haemolytic streptococcus group G and IFN-gamma responses to Lens culinaris lectin and concanavalin A were normal. Also, basal and in vitro IFN enhanced natural killer (NK) cell activity and T cell mitogen-induced cell proliferation were similar in patients and controls. During 90 days of IFN therapy, SACoI-induced IFN responses became entirely undetectable. There were transient declines at 1 and 30 days in IFN responses to the other IFN inducers, of mitogen-induced lymphocyte proliferation and of basal NK activities. The increments of NK cell activities after in vitro IFN exposure were clearly decreased in IFN treated patients, suggesting in vivo activation of these cells. Thus, the results demonstrate one remarkable abnormality in carcinoid patients: a deficient IFN response to SACoI and a clear influence of IFN therapy on several parameters of the IFN-NK system.
Clin Exp Immunol 1983 Sep
PMID:Evaluation of the natural killer cell-interferon system in patients with mid-gut carcinoid tumours treated with leucocyte interferon. 661 63

Glibenclamide was administered to five non insulin dependent diabetic (NIDD) patients, whose hyperglycaemia was not controlled by diet alone. The plasma glucose and insulin porfile was determined under strictly standardised conditions before, after the first administration and after 6 months of treatment with glibenclamide. A rapid and satisfactory lowering of plasma glucose was observed in all patients after the first administered dose and a very similar response was seen after 6 months of therapy, when glibenclamide was administered once a day. Despite a consistent plasma glucose lowering effect a very variable plasma insulin response was evident between the patients. This difference may be of relevance in the long term prognosis of these patients with respect to atherogenesis. For the period of the study weight gain was minimal, no episodes of hypoglycaemia or alcohol induced flushing were recorded.
Diabete Metab 1980 Sep
PMID:The effect of glibenclamide on the glucose and insulin profile in maturity onset diabetics following both acute and long term treatment. 677 11

Six postmenopausal women with frequent attacks of flushing were studied by measuring plasma luteinizing hormone (LH), follicle stimulating hormone (FSH), prolactin and noradrenaline concentrations at regular and frequent intervals and at the time of each of 82 flushes. The hormone measurements were made on a control day and on the second day during infusion of either naloxone (22 micrograms/min) or saline. The perception of a flush was associated with a significant increase of plasma LH concentrations. There were no significant changes in plasma FSH, prolactin or noradrenaline concentrations. Naloxone infusion resulted in a highly significant reduction in the frequency of flushes and in the number of LH pulses. We conclude that flushing and its neuro-endocrine correlates are related to activation of opiate receptors. Naloxone may provide the basis for a non-steroidal treatment of climacteric flushing attacks.
Br J Obstet Gynaecol 1981 Sep
PMID:Climacteric flushing: clinical and endocrine response to infusion of naloxone. 679 84

Many diabetics who take chlorpropamide (a sulphonylurea compound) experience facial flushing after drinking even small amounts of alcohol. These flushers have a noticeably lower prevalence of late complications of diabetes (microangiopathy, macroangiopathy, and neuropathy) than non-flushers. This flush reaction is accompanied by increased blood acetaldehyde concentrations, suggesting an inhibition of aldehyde dehydrogenase activity. In the present study the activity of this enzyme in erythrocytes was assessed in the absence of chlorpropamide. Erythrocyte homogenates obtained from flushers and non-flushers were incubated with acetaldehyde and the rate of metabolism studies. Flushers eliminated acetaldehyde more slowly at a low range of concentrations (0--30 mumol/l), suggesting a difference in aldehyde dehydrogenase activity. Further studies are needed to clarify the role of this enzyme in the pathogenesis of diabetic complications.
Br Med J (Clin Res Ed) 1982 Sep 25
PMID:Chlorpropamide-alcohol flushing, aldehyde dehydrogenase activity, and diabetic complications. 681 Oct 34

Chlorpropamide-alcohol flushing (CPAF) has been advanced and challenged as a specific marker for familial noninsulin dependent diabetes mellitus. The previous studies assay flushing reactions employing arbitrarily defined critical threshold values of rise and rate of rise in facial temperature. Since these methods ignore the curvilinear relationship between skin temperature and cutaneous blood flow, errors of analysis obtained, Further, the role of baseline facial temperature is obfuscated. The method of malar thermal circulation index derived from the relationship between skin temperature and cutaneous blood flow provides a more accurate assay method and permits the characterization of the role of baseline facial temperature. Baseline facial temperature is less in subjects with CPAF and noninsulin dependent diabetes than in normal subjects. The lower baseline facial temperature alone may account for the reported differences in the parameters of the CPAF test.
Metabolism 1982 Sep
PMID:Chlorpropamide-alcohol flushing, malar thermal circulation index, and baseline malar temperature. 712 Dec 66

A procedure using published surgical techniques is described for determining the effects of antiplasma membrane antibodies on sperm-egg binding, penetration, and fertilization in vivo in the domestic pig. Time of ovulation was controlled and sperm inseminated at precise times relative to ovulation. Sperm were exposed to antibodies (Fab) and then washed free of excess antibody and placed in one uterine horn near the uterotubal junction. Sperm exposed to control material were placed in the opposite horn as a control. One horn was tied with two ligatures near the body of the uterus. Eggs were collected by flushing the oviducts at prescribed times after insemination. in nine animals used for this study, antibodies to boar sperm plasma membranes completely blocked sperm-zona binding, penetration of the zona, and fertilization. In contrast, sperm were bound to the zona pellucida and penetrated eggs in every case on the control side. These results indicate that insemination in vivo is useful in screening antibodies produced against specific plasma membrane antigens to determine their role in fertilization.
J Exp Zool 1982 Sep 20
PMID:The effects of antisperm plasma membrane antibodies on sperm-egg binding, penetration, and fertilization in the pig. 713 Sep 38

Chlorpropamide alcohol flushing (CPAF) in non-insulin-dependent diabetics (NIDDs) has been reported to be associated with a lower tendency to develop late complications. The flush was thought to be mediated by enkephalins and prostaglandins. Early studies could not correlate CPAF to increased levels of acetaldehyde in blood and the flush was not regarded as an antabuse-like reaction. In this study, the increase of plasma acetaldehyde during the flush in 13 CPAF positive diabetics was significantly (P less than 0.005) higher than in the 13 CPAF negative diabetics during a CPAF challenge test. The increase of plasma acetaldehyde was reduced to the level of CPAF negative diabetics in three CPAF positive diabetics when they were exposed to alcohol without premedication with chlorpropamide and they did not flush. The normal breakdown of ethanol to acetic acid via acetaldehyde appears to be inhibited by chlorpropamide in the flushers. Acetaldehyde measurement is an objective method to study the chlorpropamide alcohol flush and it appears superior to the measurement of skin temperature.
Diabetes 1981 Sep
PMID:Increase of plasma acetaldehyde. An objective indicator of the chlorpropamide alcohol flush. 726 73

Pregnant and non-pregnant ewes were utilized to determine whether the presence of the embryo affected the binding of prostaglandin (PG) F-2 alpha to a uterine luminal protein. The uterine horn adjacent to the corpus luteum was flushed on Day 13 of gestation or the oestrous cycle. Flushings were incubated with [3H]PGF-2 alpha and subsequently eluted through a Sephadex column. Uterine luminal proteins of pregnant and non-pregnant ewes eluted with the void volume and failed to bind PGF-2 alpha.
J Reprod Fertil 1981 Sep
PMID:In-vitro binding of prostaglandin F-2 alpha to uterine luminal proteins of pregnant and non-pregnant ewes. 727 21


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