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Query: UMLS:C0016382 (flushing)
 6,387 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Data from studies in diabetic rodents and evidence from clinical situations of severe resistance to insulin suggest that insulin-like growth factor I (IGF-I) is able to at least partly overcome insulin resistance. To assess the efficacy of recombinant human IGF-I in subjects with the most common form of insulin resistance, e.g., obese, type II diabetic patients, we administered recombinant human IGF-I (rhIGF) in doses of 120 and 160 micrograms/kg twice daily for 4-52 days to seven such individuals who had been treated previously with high doses of insulin (> 0.7 U.kg-1 x day-1). Four patients exhibited comparable or enhanced, whereas three had diminished, blood glucose control on rhIGF-I relative to that while on twice daily NPH insulin during the six-week control period. The occurrence of adverse effects in all patients compelled us to discontinue rhIGF-I administration before completing the 8-week treatment period. These adverse effects included edema primarily on the face and hands, mild weight gain, occasional dyspnea, bilateral jaw tenderness, arthralgias and myalgias, fatigue, tachycardia, flushing, orthostatic hypotension, and local burning at the injection site. We conclude that the frequency and severity of side effects associated with administering high-dose subcutaneous rhIGF-I to obese insulin-resistant diabetic patients make it an unacceptable therapeutic agent for these patients despite its ability to produce reasonable blood glucose control in approximately 50% of them.
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PMID:Adverse effects of recombinant human insulin-like growth factor I in obese insulin-resistant type II diabetic patients. 831 9

This paper reviews some important links between nutrition and reproduction in a seasonal breeder, the mink (Mustela vison). The energetic costs of reproduction in mink are partly covered by mobilization of body fat reserves. A reduced food supply before the breeding season is detrimental to reproductive performance, and release of LH and ovulation may not occur in animals in extremely poor body condition. Nutritional flushing comprising a 2 week period of slightly restricted feeding, followed by ad libitum feeding for 4-5 days before the start of the mating season can influence reproductive performance positively. Reproductive endocrinology, ovulation and implantation rate, and early embryo development are affected by the modification of important metabolic signals including insulin, insulin-like growth factor I (IGF-I) and the thyroid hormones.
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PMID:Links between nutrition and the reproductive axis in a seasonal breeder, the mink (Mustela vison). 1178 96