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Query: UMLS:C0016382 (flushing)
 6,387 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Objective measurements of temperature and blood flow changes by telethermometry and laser Doppler velocimetry (LDV), respectively, were performed continuously in normal subjects after they ingested 0.4 g/kg of ethanol in a volume of 300 mL. Cutaneous temperatures were interpreted by the change in malar thermal circulation index (delta MTCI) method. Both the delta MTCI method and LDV output correlated significantly with the presence of flushing. The delta MTCI method also correlated significantly with LDV output, indicating that the intensity of the flushing reaction can be assessed by both methods. The sensitivity, specificity, and predictive value of a positive result were greater with the LDV method. The time to maximum delta MTCI correlated quite closely with the time to maximum LDV output. The results indicate that both LDV and delta MTCI methods are valid, noninvasive assays for flushing reactions.
Arch Dermatol 1986 Jan
PMID:Quantitative assessment of alcohol-provoked flushing. 293 88

Despite the systemic nature of many agents that provoke flushing reactions, the erythema is most prominent in the "blush area." To elucidate the physiologic basis for such a limited distribution, two types of flushing challenges were studied in normal volunteers. Nicotinic acid provokes flushing through a direct action of vasodilator prostaglandins on vascular smooth muscle. The flushing reaction provoked by oral thermal challenge is mediated via neural mechanisms. Both agents led to increases in cutaneous blood flow at both malar and forearm sites. Both absolute and proportional increases were consistent with the view that the greater vascular capacitance in the visible, superficial cutaneous vasculature in the blush area accounts for the limited distribution of flushing in response to a systemic stimulus.
J Am Acad Dermatol 1988 Aug
PMID:Why is flushing limited to a mostly facial cutaneous distribution? 304 91

Urticaria pigmentosa, characterized by cutaneous mast cell proliferation, usually occurs sporadically in childhood and resolves over a period. Rarely is the condition seen in two or more members of a family. We encountered a family in which urticaria pigmentosa occurred in four members of two generations. Skin findings were similar in all four. No systemic manifestations other than occasional flushing episodes were noted in any of the affected individuals. HLA typing was performed, but no significant correlation between affected and unaffected individuals was seen. In a review of a number of previously reported cases, we found a slight female preponderance.
Arch Dermatol 1986 Jan
PMID:Familial urticaria pigmentosa. 345 8

A questionnaire survey of British tanning salon clients disclosed that immediate side effects occurred more frequently in women using oral contraceptives. 20 questionnaires distributed to each of 146 UV-A lamp tanning salons nationwide in 1985 covered 24 questions on topics such as age, sex and skin type of the respondents, skin conditions such as acne and psoriasis, satisfaction with tan, and side effects including erythema (redness), itching, rash and nausea. Half of the subjects were young women aged 15-30, who had used the sunbed 10 to 100 times (median 20 times). Most sessions lasted 30 minutes. 98% reported that they tanned; 83% claimed they felt more relaxed; 28% complained of itching; 8% had rash or nausea. Among those with side effects, 41% with itching took oral contraceptives, compared to 27% who did not (p.005). 17% of pill users had nausea and 14% got a rash, compared to 10 and 7% of non-pill users, respectively (p.025). 195 or 19% of the 1013 respondents were on the pill. There are several conditions known to predispose to skin reddening, irritation or possibly carcinogenesis: fair skin; idiopathic light sensitivity; use of certain cosmetics or drugs such as antibiotics, antihypertension drugs, or antipsychotic agents.
Br J Dermatol 1986 Jul
PMID:Use of UV-A sunbeds for cosmetic tanning. 373 Feb 79

Monosodium glutamate is widely regarded as the provocative agent in the "Chinese restaurant syndrome," of which flushing is regarded as part of the reaction. Six subjects were monitored by laser Doppler velocimetry for changes in facial cutaneous blood flow during challenge with monosodium glutamate and its cyclization product, pyroglutamate. Additionally, records of patients challenged with monosodium glutamate in the laboratory were reviewed. No flushing was provoked among the twenty-four people tested, eighteen of whom gave a positive history of Chinese restaurant syndrome flushing. These results indicate that monosodium glutamate-provoked flushing, if it exists at all, must be rare. Monosodium glutamate and its cyclization product, pyroglutamate, may provoke edema and associated symptoms.
J Am Acad Dermatol 1986 Aug
PMID:Does monosodium glutamate cause flushing (or merely "glutamania")? 374 27

A 51-year-old woman had a severe pustular contact hypersensitivity reaction to fluorouracil used to treat actinic keratoses on the face. The reaction was composed of long-lasting redness, facial flushing, exaggerated skin markings, and sensory changes. Physicians prescribing topical fluorouracil should be aware of its potential to produce such a severe reaction.
Arch Dermatol 1985 Feb
PMID:Pustular contact hypersensitivity to fluorouracil with rosacealike sequelae. 397 40

A 70-year-old man had frequent flushing attacks and a carcinoid tumour was verified histologically. The characteristics of his flushing reaction were typical of climacteric flushing and he had undergone orchiectomy for adenocarcinoma of the prostate 2 years ago. Laboratory studies indicated a normal production of serotonin and excretion of 5-hydroxyindoleacetic acid. A rapid and complete remission of the flushing attacks was obtained with oral diethylstilbesterol therapy. Thus, although the patient had a carcinoid tumour, he was having post-orchiectomy climateric flushing reactions.
Br J Dermatol 1985 Mar
PMID:Climacteric flushing in a patient with carcinoid tumour. 397 40

We evaluated the roles of endogenous opioid peptides and histamine in the pathophysiology of alcohol-induced facial flushing in rosacea. Non-diabetic patients with rosacea ingested 360 ml of 6% ethanol after receiving either subcutaneous naloxone hydrochloride or oral chloropheniramine maleate. Only pretreatment with naloxone blocked the alcohol-induced rosacea flushing (AIRF), suggesting an active role of endogenous enkephalin and/or endorphin in this vascular reactivity. In this respect, AIRF is similar to chlorpropamide alcohol flushing and menopausal flushing.
Br J Dermatol 1982 Jul
PMID:Alcohol-induced rosacea flushing blocked by naloxone. 621 51

The effects of clonidine hydrochloride, an agent effective in suppressing other types of flushing reactions, were investigated in patients with erythematotelangiectatic rosacea. Clonidine hydrochloride, 0.05 mg, was given orally twice daily for two weeks. Mean arterial BP was not altered during clonidine treatment. Flushing reactions provoked with water at 60 degrees C, red wine, and chocolate were not suppressed during clonidine treatment. Clonidine did lead to malar hypothermia. It may be that any treatment benefit obtained from the reduction in vascular reactivity by clonidine in rosacea is offset by the malar hypothermia.
Arch Dermatol 1983 Mar
PMID:Effect of subdepressor clonidine on flushing reactions in rosacea. Change in malar thermal circulation index during provoked flushing reactions. 621 89

Flushing in rosacea has been investigated by means of (a) pharmacological inhibition of some possible chemical mediators and (b) titration of bradykinin as a possible effector directly in the blood. Clonidine-inhibited flushing was seen in all patients (mean 45%), other drugs had poorer results. Bradykinin increased in all patients at the climax of flushing (mean 60%). These findings support the hypothesis that epinephrine promotes a bradykinin release responsible for vasodilation.
Arch Dermatol Res 1982
PMID:Flushing in rosacea: a possible mechanism. 621 30


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