Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0016382 (
flushing
)
6,387
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Adenosine triphosphate
(
ATP
) is an alternative to dipyridamole or adenosine in thallium-201 myocardial scintigraphy. However, the optimal dose of
ATP
has not been determined. A Doppler guide wire study showed the coronary flow velocity at a dose of 0.15 mg/kg of
ATP
was equal or higher than that at 0.14 mg/kg of adenosine or 0.56 mg/kg of dipyridamole.
ATP
was given intravenously to 67 patients with coronary artery disease at 0.15 mg/kg/min for 6 min. Thallium-201 was injected at 3 min, followed by immediate and delayed (3 hrs) tomographic imaging. There was no serious side effect during examination, although chest pain (26%), dyspnea (17%), and
flushing
(33%) were common. The sensitivity and specificity to detect coronary artery disease were 98 and 100%, respectively. The sensitivity to detect left anterior descending artery, left circumflex artery, and right coronary artery lesions was 94, 59 and 77%, respectively.
ATP
loading thallium-201 scintigraphy provides an accurate diagnosis of coronary artery disease. The optimal dose of
ATP
is 0.15 mg/kg/min for 6 min.
...
PMID:[Adenosine triphosphate loading thallium-201 myocardial scintigraphy: optimal dose and diagnostic accuracy]. 787 4
