Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0016382 (flushing)
 6,387 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Hormonal and cardiovascular responses to 1-desamino-8-D-arginine vasopressin (DDAVP) were investigated in six normal adult volunteers. After overnight fluid deprivation, an intravenous injection of either DDAVP (0.4 microgram/kg) or the same volume of normal saline was administered. One hour later an intravenous infusion of hypertonic saline was commenced and continued over two hours. Five minutes following the DDAVP injection, facial flushing, a fall in diastolic blood pressure by an average of 13% and a rise in pulse rate by an average of 18% were observed. There was a significant increase in plasma renin activity and plasma cortisol concentration, but no significant changes were observed in plasma concentrations of LH, FSH, TSH, prolactin or GH. Following osmotic stimulation by hypertonic saline plasma AVP rose to the same extent in both the DDAVP and control studies. DDAVP (0.4 microgram/kg) was also administered to five subjects with cranial diabetes insipidus. Again facial flushing, increased facial temperature, a fall in diastolic pressure and a rise in heart rate were all observed, suggesting that DDAVP exerts its cardiovascular actions by a mechanism other than antagonism of circulating endogenous AVP.
 ...
PMID:Hormonal and cardiovascular responses to DDAVP in man. 351 5

There are inherent complications associated with chronic indwelling venous catheters for use as bleed catheters in long term hemorrhage experiments in conscious animals. As an alternative we have developed a protocol for bleeding conscious rabbits using a disposable catheter in the central ear artery. Previously we had bled rabbits through a catheter chronically implanted in the inferior vena cava (IVC); thus, we were interested in any potential differences in the hormonal (vasopressin and renin) and cardiovascular profile during hemorrhage between the IVC and ear artery bleeds. Rabbits underwent two bleeds, 1 week apart, one using the indwelling IVC catheter and the other with an ear artery (EA) catheter. We compared the mean arterial pressure (MAP), heart rate (HR), plasma vasopressin (AVP), and plasma renin activity (PRA) before and during hemorrhage. Baseline cardiovascular and hormonal values were the same, regardless of choice of bleed site. In addition there were no differences between bleed sites in the rate of fall of MAP (slope: IVC, 0.24 +/- 0.05; EA, 0.26 +/- 0.04) and the rate of rise of HR (slope: IVC, -1.37 +/- 0.22; EA, -1.20 +/- 0.19). Finally the AVP and PRA values associated with a MAP of 50 mmHg (1 mmHg = 133.3 Pa) (close to peak levels achieved during the hemorrhage) were also not different between IVC and EA bleeds. Given that the profiles of the bleeds were not different and that surgical implantation, possible infection, and daily flushing were avoided by the use of the EA catheter, we concluded that use of the EA as a site for bleeding conscious rabbits was justified.
 ...
PMID:Hemorrhage from the inferior vena cava versus the ear artery: a comparison of cardiovascular and hormonal responses in conscious rabbits. 795 3