Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0016382 (
flushing
)
6,387
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
During a control infusion noradrenaline and alcohol each provoked carcinoid
flushing
in four of five patients and pentagastrin in two of five patients. When tetradecapeptide somatostatin was infused on another day no patient flushed at any time, even when 16 microgram of either noradrenaline or pentagastrin were administered. Carcinoid
flushing
was not associated with release of gastrin or any of the other vasoactive or postprandially released gut regulatory peptides measured. In a sixth patient with severe prolonged carcinoid
flushing
, subcutaneous Des
AA1
, 2, 4, 5, 12D Trp8 somatostatin markedly reduced the incidence and severity of
flushing
for two days. Somatostatin is thus a potent inhibitor of carcinoid
flushing
, but no evidence has been found for the gut hormones measured to be mediators of
flushing
.
...
PMID:Somatostatin, gastrointestinal peptides, and the carcinoid syndrome. 611 1
