Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0016382 (flushing)
 6,387 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The interaction of cyclohexapeptides c(X(1)(1)K(2)X(2)(3)K(4)X(3)(5)K(6)) in water with hydrolysed silicon surfaces were studied by attenuated total reflection Fourier transform infrared (ATR FTIR) spectroscopy and by force field calculations. The band sequences (1800-1500 cm(-1)) for dissolved and adsorbed cyclohexapeptides were recorded and compared with those obtained after flushing with distilled water in order to eliminate the background signal of the peptides in solution. Band analyses and principal component analyses were carried out for the characteristic peptide vibrations in order to evaluate the spectra. In addition, force field calculations were performed to study the binding energies to the surface and to illustrate the possible structures of the cyclohexapeptides. The positively charged lysine side chains of the cyclohexapeptides interact with the OH groups of the surface, as indicated by band shifts. This also was verified by the force field calculations. The bonding stability increases with the number of interacting sites (lysine side chains and other peptide residues) to the surface. These sites are determined by structure and polarity of the cyclohexapeptides.
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PMID:Small interacting peptides. Part I. Interaction of cyclohexapeptides with an unspecific SiOH surface: comparison of infrared investigations and force field calculations. 1260 33

We discuss the use of aqueous NaOH as a facile surface treatment method to control the electroosmotic flow in PDMS microchannels. Flushing of PDMS/PDMS and glass/PDMS microchannels with 1 M NaOH for 24 h leads to a doubling of the electroosmotic flow. This high flow rate is comparable to the flow rates achieved by treating PDMS microchannels with O2 plasma. Contact angle measurements and ATR-FTIR analysis show that the surface chemistry of the NaOH treated PDMS differs from O2 plasma treated PDMS. An important advantage of the NaOH treated surfaces is the enhanced stability, irrespective of whether the devices are stored in air or water.
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PMID:Sodium hydroxide treatment of PDMS based microfluidic devices. 2060 82