Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0016382 (flushing)
 6,387 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Tricyclic antidepressant overdose is the most common cause of death from prescription drugs. Clinical presentation of overdose from the tricyclic agents includes cardiac arrhythmias, hypotension, seizures, coma and anticholinergic signs such as hyperthermia, flushing and intestinal ileus. The highly toxic/lethal level (greater than 1,000 ng per mL) is manifested on electrocardiograms as prolongation of the QRS interval to 100 milliseconds or more. Treatment includes establishment of an airway, proper oxygenation and ventilation, fluid replacement at maintenance levels, cardiac monitoring, gastric lavage and charcoal administration, alkalinization to a blood pH of 7.5 with intravenous sodium bicarbonate, supportive therapy and continued cardiac monitoring after clinical recovery.
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PMID:Managing tricyclic antidepressant overdose. 162 27

When the causes and pathophysiology of the various types of ileus are known there are numerous possibilities of preventing them and logical therapeutic approaches, in particular in the case of functional ileus. Careful postoperative monitoring is obligatory! With regard to stimulation of bowel function, the principle of elimination of inhibition of motility by sympathicolysis has a place alongside the well-known nonspecific measures and direct stimulation. If conservative measures fail laparotomy must be repeated as soon as possible to procure relief. In the treatment of ileus associated with peritonitis the numerous new methods of flushing the abdomen, the involvement of anaerobes in some cases, and the possibilities offered by new antibiotics should be kept in mind. The involvement or predominance of mechanical ileus factors in the clinical picture must be recognized early and surgery performed without delay. Early consultation of an abdominal surgeon is recommended.
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PMID:[Postoperative ileus]. 359 6

Magnesium is one of the most abundant cations in the body and is essential for a wide variety of metabolically important reactions. Serum magnesium concentration is regulated by the balance between intestinal absorption and renal excretion. Hypomagnesaemia is relatively common, with an estimated prevalence in the general population ranging from 2.5 to 15%. It may result from inadequate magnesium intake, increased gastrointestinal or renal loss or redistribution from extracellular to intracellular space. Drug-induced hypomagnesaemia, particularly related to proton-pump inhibitor (PPI) therapy, is being increasingly recognized. Although most patients with hypomagnesaemia are asymptomatic, manifestations may include neuromuscular, cardiovascular and metabolic features. Due to the kidney's ability to increase fractional excretion to nearly 100% when the renal magnesium threshold is exceeded, clinically significant hypermagnesaemia is uncommon, generally occurring only in the setting of renal insufficiency and excessive magnesium intake. Symptoms include hypotension, nausea, facial flushing, ileus and flaccid muscle paralysis. In most cases, simply withdrawing exogenous magnesium is sufficient to restore normal magnesium concentrations, although occasionally administration of intravenous calcium or even dialysis may be required.
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PMID:Contemporary view of the clinical relevance of magnesium homeostasis. 2440 2