Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0016199 (flank pain)
 2,189 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We report the case of a 25-year-old woman who presented with abdominal and flank pain with two successive pregnancies and was diagnosed of giant bilateral renal AMLs and pulmonary LAM associated with TSC in the post-partum of her second pregnancy. This case illustrates that in women with TSC rapid growth from renal AMLs and development of LAM may occur with successive pregnancies. It also stresses the potential for preservation of renal function despite successive bilateral renal surgery of giant AMLs. Moreover, the treatment with a low-dose rapamycin may be an option for LAM treatment. Finally, a low-dose rapamycin may be considered as an adjuvant treatment together to kidney-sparing conservative surgery for renal AMLs.
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PMID:Giant bilateral renal angiomyolipomas and lymphangioleiomyomatosis presenting after two successive pregnancies successfully treated with surgery and rapamycin. 2212 60

Renal angiomyolipoma (RAML), a rare benign mesenchymal tumor, consists of variable proportions of thick-walled blood vessels admixed with adipose tissue and bundles of smooth muscle. Rarely, RAML angiomyolipoma may be associated with pseudoaneurysm, spontaneous rupture and hemorrhage. we herein present an exceptional case of fat-poor RAML containing a large pseudoaneurysm in a 48-yearold woman with known pulmonary lymphangioleiomyomatosis (PLAM), who was admitted to hospital due to right flank pain for about two months. To avoid risk of rupture of the pseudoaneurysms, transcatheter arterial embolization (TAE) procedure was performed, at the same time taking into account of the possibility of malignancy in such a large neoplasm, right radical nephrectomy was taken five days later. This case was benign and the 1-year follow-up ultrasonic examination showed no recurrence. This is the first report that the patient had a sporadic giant RAML with pseudoaneurysm which was not associated with the TSC, and to our knowledge, such cases have not been explored in literature. This case reminds us that giant sporadic RAML with pseudoaneurysm, although rare, does exist, and we should improve the understanding of the neoplasm. Early detection and therapeutic interventions of pseudoaneurysm in an AML patient can reduce serious complications.
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PMID:Fat-poor renal angiomyolipoma combined with pseudoaneurysm: a case report. 3252 22

Tuberous sclerosis complex has several renal manifestations like angiomyolipomas. We report a case of a giant AML and discuss its diagnosis and treatment. A 42-year-old woman was admitted to emergency department due to flank pain and hematuria. The patient had history of mental retardation and epilepsy. Abdominal CT without contrast medium revealed a large mass with a fat/blood content inside. On those findings, we diagnosed the patient a bleeding giant AML. We performed selective embolization of the bleeding source with subsequent conservative management. TSC-associated AMLs occur more frequently as multiple lesions and grow to larger size than idiopathic AML.
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PMID:Conservative treatment of monolateral giant renal angiomyolipoma in a patient with Tuberous Sclerosis Complex (TSC): A case report. 3310 10