Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0016199 (flank pain)
 2,189 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Schwannomas (also known as Neurilemomas or Neurinomas) are benign tumors of the nervous system that originate in the neural sheath and most commonly occur as solitary encapsulated subcutaneous tumors in otherwise healthy individuals. When they present as multiple tumors, they are histologically indistinguishable from the solitary tumors and, in such a case, they may be associated with neurofibromatosis 2 (NF2) in which the sensory roots of the cranial and spinal nerves are affected more often than the motor roots and the hallmark tumor of which is a vestibular schwannoma (also known as acoustic neuroma). They also may exist as a distinct clinical entity without any stigmata of neurofibromatosis known as schwannomatosis. Generally, schwannomas are less than 5 cm in diameter but sizes greater than 14 cm have been reported. They present as slow growing masses and may present with pain or neurological symptoms. Here we report a patient with sympathetic schwannoma who presented with right flank pain.
Conn Med 1999 Jul
PMID:Sympathetic schwannoma: a case report. 1046 9

Tuberous sclerosis was first described in 1862 by von Recklinghausen. Since then there have been many advances in our understanding of the diagnosis, pathogenesis, and treatment of this disease complex, especially after it was characterized genetically. While many patients who have tuberous sclerosis present with the classic triad of mental retardation, seizures, and facial "adenoma sebaceum," most do not because of its variable penetrance. The diagnostic criteria have been revised to include patients with tuberous sclerosis who do not match the classic pattern. Here we describe a 44-year-old female without a prior diagnosis who did not have the classic triad but who presented with flank pain. Hemorrhagic angiomyolipoma was diagnosed by computerized tomography scan and she was treated by an embolization procedure. We review tuberous sclerosis and underscore the need to consider this diagnosis for the following reasons: 1. it is not uncommon (slightly more than one in 6,000 live births); 2. its presentation is protean; 3. once the diagnosis is made, search can be made for associated findings that may lead to additional morbidity if not carefully managed, e.g., if an angio-myolipoma is diagnosed, it can be followed and possibly treated; and 4. owing to its autosomal dominant pattern of inheritance, members of the family can be screened appropriately.
Conn Med 2002 Aug
PMID:Hemorrhagic angiomyolipoma and tuberous sclerosis complex: a case report. 1280 49

Renal cell carcinoma (RCC) usually remains clinically silent posing a great challenge to early diagnosis. The classic triad of flank pain, hematuria, and flank mass is uncommon and presents in only 10% of cases. RCC is frequently associated with various paraneoplastic syndromes. We report a case of an elderly female with sarcomatoid renal cell carcinoma presenting with acute pancreatitis (paraneoplastic phenomenon), and provide a brief review of the literature. The diagnosis is established on the basis of radiological findings and histopathology.
Conn Med 2007 Feb
PMID:Renal cell carcinoma--a great mimicker. 1739 99