Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0016199 (flank pain)
 2,189 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 26-year-old female visited our hospital complaining left flank pain and macroscopic hematuria. She had been suffering ulcerative colitis and administered salazosulphapyridine and predonisolone from 17-year-old. Intravenous urography showed radiolucent multiple stones in the left renal pelvis. Three sessions of extracorporeal shock wave lithotripsy were performed after ureteral stenting. Although disintegration and discharge of the stones were satisfactory, bladder stone induced by ureteral stent was complicated. The extracted bladder stone showed a yellowish brown color and the surface was granular shape. Composition of the stone was acetyl sulphapyridine which was a metabolite of salazosulphapyridine. After maintenance of the urinary pH ranges between 6.5 and 7.5 by medication of sodium bicarbonate, the patient remains free of stone for 3 years. Drug induced urolithiasis originated from salazosulphapyridine is extremely rare. Satisfactory oral fluid intake and urinary alkalization are important for prevention of sulpha drugs calculi of urinary tract.
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PMID:[A case of drug induced urolithiasis composed of acetyl sulphapyridine associated with ulcerative colitis]. 1034 5

We present a case of a young man, known case of ulcerative colitis, who presented with acute onset right flank pain and haematuria. Blood workup showed leucocytosis and raised serum creatinine. Cross-sectional imaging revealed renal vein with inferior vena cava thrombosis. He had a normal infectious screen and lacked septic features pointing towards non-infectious pathology. The 24-hour urine examination revealed nephrotic range proteinuria. Further evaluation was inconclusive for any defined pathology. Empiric anticoagulation was started and patient responded miraculously with restoration of vascularity to the affected kidney and discharged in stable condition.
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PMID:Isolated renal vein and inferior vena cava thrombosis in a young man with ulcerative colitis: diagnostic challenges and lessons learned. 3330 5