Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0016199 (flank pain)
 2,189 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Renal cell carcinoma in children is extremely rare compared to Wilms tumor. We report on a 7-year-old Japanese boy with left renal cell carcinoma. Since the disease was clinical stage I, nephrectomy with tumor extirpation was performed after a short course of initial chemotherapy had been administered. The patient is free of disease 3 years postoperatively. In a review of the Japanese literature we found 71 reports of renal cell carcinoma in children less than 15 years old. Mean patient age at occurrence was 8.1 years, there were no differences in regard to the sex or the affected side, and the most frequent symptom was the presence of a mass. We stress the early establishment of diagnosis in children with a persistent abdominal mass, hematuria and flank pain, since surgical treatment leads to a favorable prognosis only in the early stage of renal cell carcinoma.
 ...
PMID:Renal cell carcinoma in Japanese children. 377 1

A 61-year-old man with a history of hemodialysis for 10 years, and complaining of fever and right flank pain was introduced to us with the suspicion of right renal tumor and admitted on May 19, 1984. Right radical nephrectomy was done and the histological diagnosis was renal cell carcinoma (clear cell type) with acquired cystic disease of the kidney (ACDK). On the 27th day after operation, spontaneous rupture of bladder, despite its lack in functioning was suspected and an emergency operation was done. The bladder wall was very thin and weak and it was lacerated about 5 cm. After this operation the blood pressure was unstable and the patient died on the 64th day after nephrectomy due to sepsis. In Japan, 9 cases (containing this case) of renal cell carcinoma associated with ACDK were reported. The mean age and the mean duration of dialysis were 37.4 years old and 6.7 years. The cause of bladder rupture (1973-1983) in 87 cases is discussed.
 ...
PMID:[Renal cell carcinoma in a long-term hemodialysis patient: a case report of its interesting clinical course]. 378 38

The classic triad of hematuria, flank pain and abdominal mass is present in only 15 percent of patients with adenocarcinoma of the kidney. In one-third of patients, metastases are present at the time the tumor is discovered. Contour abnormalities of the kidney, displacement of portions of the collecting system and altered axis of the kidney may be seen on intravenous pyelogram. The presence of calcification within a renal mass should increase the index of suspicion for malignancy.
 ...
PMID:Adenocarcinoma of the renal parenchyma. 388 76

From 1955 through 1984, 17 patients aged 17 years or younger were treated or seen in consultation for renal cell carcinoma at the Children's Hospital and Dana Farber Cancer Institute. There were 11 girls and 6 boys, with an average age at diagnosis of 11 years (range 4 to 17 years). Gross hematuria and abdominal or flank pain were the most common presenting complaints, and in 5 cases there was a history of antecedent trauma. The tumors ranged in size from 2 to 15 cm. (average diameter 7.5 cm.). There were 10 tumors in the left kidney and 7 in the right kidney. Childhood renal cell carcinoma displayed similar gross and microscopic features compared with counterparts in adults. The smallest renal cell carcinoma to metastasize measured 3 cm. in diameter and the pathological features suggested an origin from distal collecting tubules (ducts of Bellini). There were 6 tumor-related deaths (35 per cent over-all mortality) occurring 2 months to 2 years after diagnosis. Eleven children were well, with an average duration of followup of 12 years (range 4 to 27 years). The most important prognostic factor was clinical stage at the time of diagnosis. The presence of renal vascular invasion per se did not appear to be an adverse finding. The most optimal treatment for children with stage I renal cell carcinoma is radical nephrectomy with regional lymphadenectomy. While adjuvant radiation and/or chemotherapy may be used in patients with more advanced stage disease, their efficacy in achieving long-term survival free of relapse or cure is not well defined.
 ...
PMID:Renal cell carcinoma in childhood and adolescence: a clinical and pathological study of 17 cases. 398 22

Renal arterial embolization is often used in the treatment of patients with renal cell carcinoma, either preoperatively to facilitate nephrectomy or as palliative therapy in advanced cases. Eighteen patients (18/58; 31%) underwent renal arterial embolization in our department since 1979, initial 10 cases with Gelfoam and steel coil (group G) and recent 8 cases with absolute ethanol (group A). Clinical studies of daily changes of symptoms and blood chemistry in both groups after embolization were compared and the results were as follows: Severe flank pain was noted immediately after embolization but thereafter well controlled without analgesics in group A. The patients in group G experienced no pain during the procedure of embolization but have had moderate flank pain of two or three days' duration with nausea and/or vomiting and required surgical procedure within a few days after embolization. Post embolization fever in group A was described as higher than that in group G significantly. Leukocytosis was noted to be persistent for up to seven days and blood chemistry showed transient marked elevations of GOT, GPT and LDH immediately after the procedure without significant value in both groups. Embolization to advanced tumor with many parasitic vessels or massive local invasion may not always be available for remaining of viable-appearing tumor cells in venous lumen, as if palliative treatment. Absolute ethanol may be more useful as the embolizing substance than Gelfoam and steel coil by reason of producing wide severe infarction of diseased kidney. Broad marked infarction due to renal arterial embolization may make pathological diagnosis difficult. Immunological effects of renal arterial embolization were not observed in short term patients survival.(ABSTRACT TRUNCATED AT 250 WORDS)
 ...
PMID:[Renal arterial embolization for renal cell carcinoma]. 402 78

A case of spontaneous rupture of renal cell carcinoma is reported. A 53-year old man was admitted with the chief complaint of sudden gross hematuria and right flank pain on December 28, 1979. On the following day, the clinical impression was right ruptured kidney, and therefore right nephrectomy was done. Pathological diagnosis was renal cell carcinoma. He received the post-operative irradiation of a total of 5,000 rads. He was seen five years later, at which time there was no evidence of local recurrence or distant metastasis of cancer. Thirty three cases of spontaneous rupture of renal cell carcinoma were collected from Japanese and English literature. Most common chief complaint is abdominal or flank pain. Excretory urography, ultrasonography, CT scan and angiography are useful, but it is difficult to diagnose preoperatively when the tumor is small. Therefore, it is important to suspect occult cancer when a reasonable cause of rupture is undetermined. In these indeterminate cases primary nephrectomy should be considered strongly.
 ...
PMID:[A case of spontaneous rupture of renal cell carcinoma]. 409 Nov 28

Renal cell carcinoma is the third most frequent cause of urological cancer death in Japan. The first is bladder cancer and the second is prostatic cancer. However, there has been no clinical trial of mass screening for early detection of renal cell carcinoma. With a view to discovering a method of early detection for renal cell carcinoma, we analyzed the procedures for discovering renal cell carcinoma in 33 patients who were treated at our hospital. In 10 patients, carcinoma had been discovered accidentally without gross hematuria, abdominal mass or flank pain. Seven of these patients were first suspected of having renal cell carcinoma by ultrasonography, two by intravenous pyelography (IVP) and one by computed tomography. Seven out of nine patients operated on were surgically diagnosed as having stage I and two as having stage II. Ultrasonography is far better than IVP from the points of view of noninvasiveness, ease of performance and accuracy. In our study, ultrasonography was the most useful method for early detection of renal cell carcinoma. However, for the mass screening of renal cell cancer by ultrasonography, it is necessary to make its specificity and sensitivity clear and to debate its cost effectiveness.
 ...
PMID:The value of ultrasonography in early detection of renal cell carcinoma. 638 76

Two cases of renal angiomyolipomas in female siblings associated with tuberous sclerosis were reported. The first case was a 47-year-old housewife who visited the hospital because of severe right flank pain. Bilateral renal angiomyolipomas and hemorrhage in the right angiomyolipoma were recognized by computerized tomography, ultrasonography and renal angiography. After 2 months she had another episode of left flank pain and was diagnosed to have hemorrhage in the left renal tumor. The pain remissed by conservative treatment. Bilateral nephrectomy and hemodialysis would be necessary if she were to have a third attack. The second case was her 36-year-old sister with the chief complaint of left flank pain and genital bleeding. CT and renal angiography suggested a large angiomyolipoma in her left kidney and a small one in her right kidney. Left nephrectomy, right partial nephrectomy and hysterectomy were performed to prevent intratumoral hemorrhage. The histopathological diagnosis was angiomyolipoma of kidneys, uterus and lymphnodes of right renal hilus. Although pre-operative differentiation of angiomyolipoma from renal cell carcinoma has been difficult, recently diagnosis has become possible by CT, ultra-sonography and angiography.
 ...
PMID:[Renal angiomyolipoma: report of 2 cases of tuberous sclerosis in female siblings]. 651 96

Herein we report a case of perirenal encysted hematoma secondary to renal cell adenocarcinoma. A 57-year-old woman was hospitalized because of a palpable mass in the left flank. She had had an episode of left flank pain. X-ray studies demonstrated a tumor in the left kidney and a large cystic mass beneath the left kidney. The cyst was excised by nephrectomy. Histological examination of the large cyst revealed perirenal encysted hematoma secondary to renal cell adenocarcinoma. Six months postoperatively, she is now free from left lumbar pain, and alive with lung and liver metastasis.
 ...
PMID:[A case of perirenal encysted hematoma secondary to renal cell adenocarcinoma]. 652 44

Renal cell carcinoma is one of the most difficult malignant tumors for early diagnosis. It is rare that the classic symptoms such as hematuria, a renal mass and flank pain appear simultaneously. Only in about 7% of renal cell carcinoma patients these symptoms occurred simultaneously. Hematuria is an important symptom, and in our series 46% of the patients with renal cell carcinomas were conscious of macrohematuria as an initial symptom. As an initial symptom, a mass was palpable in 8% and flank pain was felt in 13% of the patients with renal cell carcinomas. Nonurologic symptoms were observed as initial symptoms in 33% cases, suggesting physician's particular attention on these symptoms. Initial diagnosis of renal cell carcinomas begins with urinary tract x-ray examination, which is followed by ultrasonography, CT scan, and if necessary, angiography. These procedures make definite diagnosis possible and define clinical staging. The most basic and reliable treatment method established for renal cell carcinomas is surgery--radical nephrectomy. Much cannot be expected from chemotherapy or radiotherapy as an adjuvant modality. To what extent lymphoadenectomy should be performed at the time of radical surgery is a question still to be definitely answered, but the lymph node of the renal pedicle should be removed completely. While any chemotherapeutic drug or method has not yet been established, an increasing number of useful agents have been studied. Radiotherapy is now used exclusively as adjuvant therapy for metastatic tumors. In order to improve clinical results, it is necessary to establish an appropriate approach according to clinical stage. In particular, establishment of approach to progressive carcinomas is imperative.
 ...
PMID:[Diagnosis and treatment of renal cell carcinoma]. 662 21


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>