Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0016199 (flank pain)
 2,189 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 73-year-old man was admitted to the hospital complaining of gross hematuria and left flank pain. Abdominal ultrasonography and computed tomography revealed a left renal tumor with extracapsular extension. Laboratory data showed marked leukocytosis of 121,000/mm3 and hypercalcemia of 12.3 mg/dl without any findings of inflammatory disease or bone metastasis. Enzyme immunoassay of the serum demonstrated a high level of granulocyte colony-stimulating factor (250 pg/ml) and parathyroid hormone-related protein (1,069 pmol/l). Pathological diagnosis of needle biopsy specimen of the primary tumor was transitional cell carcinoma which was suspected to have originated from renal pelvis. Immunohistochemical examination with anti-granulocyte colony-stimulating factor monoclonal antibody demonstrated granulocyte colony-stimulating factor production in cancer cells. The patient underwent a course of systemic chemotherapy, but died two months after diagnosis. To our knowledge, this is the first report of renal pelvic cancer representing granulocyte colony-stimulating factor production and hypercalcemia simultaneously.
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PMID:[Renal pelvic cancer representing G-CSF production and hypercalcemia simultaneously: a case report]. 1199 9

Over a 5-year period, 1007 patients with haematuria were investigated, using a protocol based on ultrasonography as the upper tract imaging modality of choice. Intravenous urography (IVU) was only used in selected individuals, including those patients with bladder cancer suspected on cystoscopy, suspicious or malignant cytology, previous investigation for haematuria, on-going haematuria at the time of their clinic visit, a history of flank pain or hydronephrosis on ultrasonography. Of this series, 840 (83%) had visible haematuria, 158 (15%) had microscopic or chemical haematuria and 9 (0.9%) had unspecified haematuria. A total of 133 bladder transitional cell tumours, 21 renal cell cancers and 2 upper tract transitional cell cancers (TCC) were diagnosed. The sensitivity of ultrasound with respect to bladder cancer was 63% and the specificity 99%. The odds ratio of diagnosing cancer in patients with visible haematuria compared to microscopic or unspecified haematuria was 3.3. No upper tract tumours were missed using this investigational protocol. An ultrasonography-based protocol could miss fewer upper tract TCCs than a standard IVU-based service would miss renal cell cancer. Provided there is no history of flank pain, no malignant cytology, no hydronephrosis and no previously investigated haematuria, IVU could be safely omitted.
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PMID:Urinary tract ultrasonography in the evaluation of haematuria--a report of over 1,000 cases. 1209 77

Although autopsies performed on patients with cancer have shown 4 6 to 7.6% of metastases to the kidneys, the preoperative clinical identification remains rare. The primary sources of metastases to the kidney are in decreasing order of frequency: breast, lung, intestine, contralateral kidney, stomach, ovary, cervix, pancreas, uterus, and pro tate. As far as we know, only seven cases of malignant neoplasms of the thyroid gland metastatictothe kidney have been reported [1]. Herein, we report the eighth case of this event and the second of a follicular variant of papillary thyroid carcinoma whose initial manifestation was hematuria and flank pain.
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PMID:Metastatic Follicular Variant of Papillary Thyroid Carcinoma Manifested as a Primary Renal Neoplasm. 1211 7

We report a case of carcinoembryonic antigen (CEA)-producing renal pelvic and ureteral cancer. A 62-year-old man consulted a local hospital with the chief complaint of right flank pain. On ultrasonography and CT scan, right hydronephrosis with the renal pelvis and ureteral tumor were detected, and he was referred to our hospital. Both serum levels of CEA and CA19-9 were elevated to 36.9 ng/ml and 119 u/ml, respectively. Close examination of the gastro-intestinal tract did not detect any sign of digestive tumor. Right nephro-ureterectomy was performed, and the tumor was histologically diagnosed as TCC G2 > G3 pT3, and CEA was positive in the tumor cells immunohistochemically. CA19-9 was also positive both in the tumor cells and normal epithelium of the renal tubules. Postoperatively, multiple lung metastases developed despite chemotherapy and the patient died 4 months after surgery. CA19-9 had immediately decreased to the normal range after preoperative percutaneous nephrostomy. CEA had transiently decreased postoperatively, but then increased with lung metastases, apparently related to the state of cancer.
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PMID:[A case of CEA-producing renal pelvic and ureteral cancer]. 1269 86

Malignancy may produce ureteric obstruction. This obstruction may be relieved by inserting a nephrostomy tube. All 31 cases of malignant ureteric obstruction from a single institution were retrospectively analysed. The commonest indications for nephrostomy tube insertion were renal failure (87%) and flank pain with hydronephrosis (13%). The mean serum creatinine levels pre and post insertion were 481 and 170 micromol/l, representing significant improvement (p<0.01). The complication rate was 13%, relating to tube blockage or dislodgement. Survival of patients was significantly worse if their malignancy was not resectable or suitable for chemotherapy (p=0.01). However, incurable patients still survived for a mean of 232 days, and although 46% of this time was spent as an inpatient, it did not differ significantly from the inpatient rate of curable patients (31%, p=0.1). Nephrostomy tube insertion should be considered for all palliative cases of malignant ureteric obstruction.
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PMID:Use of nephrostomy tubes in ureteric obstruction from incurable malignancy. 1272 19

This study prospectively evaluated the diagnostic value of unenhanced computerized tomography (CT) urography in patients with acute renal colic. Fifty-nine patients with clinical manifestations of acute renal colic underwent unenhanced helical CT to evaluate urinary tract abnormalities. Reformatted three-dimensional CT urography was performed in all patients. The findings were correlated with ureteroscopy, surgical findings, histopathologic findings, and clinical course. CT urography detected urinary abnormalities in 57 of 59 patients with the clinical manifestation of acute renal colic, including 45 cases of urolithiasis, three urinary malignancies, one congenital abnormality, and eight ureteral strictures (due to chronic inflammation or fibrosis). CT urography showed negative findings in the urinary system in two patients, and after clinical follow-up, urinary abnormality was excluded in these patients. Incidental findings of extrarenal disease were noted in six patients (pulmonary abnormalities, n = 2; gallstones, n = 4). Only one patient with urolithiasis was misdiagnosed as having a renal tumor by CT urography. The sensitivity and specificity of CT urography in diagnosing urolithiasis was 97.8% (44/45) and 100% (14/14), respectively. Three-dimensional CT urography is a newly developed modality to evaluate anomalies of the urinary tract. The highly accurate diagnostic value of CT urography makes it a suitable alternative or substitutive modality in patients with acute flank pain.
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PMID:Diagnostic value of unenhanced computerized tomography urography in the evaluation of acute renal colic. 1462 Jun 76

A 59-year old female presented with right flank pain and hydronephrosis. Abdominal computed tomography (CT) and magnetic resonance imaging (MRI) before admission (August 2001), revealed a periureteral mass measuring 11 cm in length along the right ureter. Since the preoperative image examinations could not exclude a malignancy, she was admitted for surgery. After admission, however, she presented no abnormal findings in laboratory investigations including tumor markers, urinalysis, urine cytology and retrograde pyelography. C-reactive protein was normalized. CT after admission (September 2001), showed spontaneous regression of the mass. We cancelled the operation and decided to carefully watch this lesion by CT. The lesion continued to regress thereafter. Judging from the clinical course, we regard the mass as inflammatory pseudotumor although pathological diagnosis was not performed. The possibility of preserving the urinary tract in this disease is discussed by reviewing the previously reported inflammatory pseudotumor of the upper urinary tract.
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PMID:[Periureteral inflammatory pseudotumor: a case report]. 1465 3

The main objective was to determine the clinical and radiological features of metanephric neoplasms. The tumors were diagnosed on histopathological examination. The clinical data and imaging features were retrospectively analyzed. Between 1998 and 2003, 3 patients underwent radical nephrectomy for renal masses turning out as metanephric neoplasms on histopathology. Two of these tumors were metanephric adenoma (MA) and one was metanephric adenofibroma (MAF). Clinical and radiological features were reviewed. All patients were adult females who presented with flank pain. Tumor was detected on screening ultrasound as a hyperechoic lesion. In all cases CT showed a hyper-attenuating exophytic lesion with cystic areas that enhanced with IV contrast. Based on combination of clinical and imaging features it may be possible to prospectively identify metanephric neoplasms and thus avoid unnecessary radical nephrectomy in favor of conservative surgery.
Indian J Cancer
PMID:Correlation of radiological and clinical features of metanephric neoplasms in adults. 1510 78

Computed tomographic (CT) imaging has become the modality of choice for the assessment of patients with urological malignancies. Recently, multi-slice CT imaging was introduced, providing faster acquisition times and higher resolution leading to improved image quality. Several studies show that thin-slice, high-resolution acquisition strategies lead to an improved accuracy for T-staging, especially of renal cell carcinomas. Three-dimensional post-processing techniques for the visualization of the vascular supply as well as the ureter (CT-angiography and CT-urography) are helpful for surgical planning. Compared to conventional imaging strategies unenhanced CT images render higher sensitivities and specificities for detecting stone disease in patients with acute flank pain. In the USA unenhanced CT imaging has almost replaced conventional urography, as no contrast agent is administered and the examination time is shorter. PET/CT examinations provide information on the morphology and function of tumors in one examination. However, there are only few data available for the assessment of urologic tumors.
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PMID:[New techniques in computed tomography. Significance for urology]. 1550 8

We report the case of a 59-year-old woman who presented with right flank pain and fever. Diagnostic investigations revealed stenosis of the right ureter extending over about 1cm. Since a double-J prosthesis could not be passed through it, a percutaneous nephrostomy was constructed and surgical exploration and excision of the stenotic ureteral segment were then carried out. Histopathological analysis of the segment removed showed diffuse infiltration with epithelial tumor cells. On immunohistochemistry, these cells were found to be positive for cytokeratin and for estrogen and progesterone receptors. No primary cancer and no additional metastases were detected. Eleven months later a primary tumor with a metastasis in the left supraclavicular region was found in the patient's right breast.
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PMID:Ureteral metastasis of occult breast cancer. 1556 65


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