Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0016053 (fibromyalgia)
 4,687 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
Sep 288
ACR 75
ankylosing spondylitis 66
substance P 60
c-fms 57
cytokine 48
Mol 40
IL-6 35
growth hormone 30
gut 27
C-reactive protein 26
opioid receptor 26
She 24
MRI 23
insulin 23
beta-endorphin 22
tumor necrosis factor 22
TNF 21
IL-10 20
brain-derived neurotrophic factor 20
ANOVA 20
rheumatoid factor 18
IL-8 17
collagen 16
HT3 16
GABA 16
ICD 16
SCL 16
REM 15
calcitonin 14
Pol 14
5-HT3 receptor 14
short form 14
interleukin-6 12
CRP 11
HPA 11
prolactin 11
IL-1 10
ACTH 10
5-hydroxytryptamine 10
enigma 10
HLA 10
interferon 10
IgA 9
hemoglobin 9
IGF-1 9
serotonin transporter 9
catechol-O-methyltransferase 9
CSF 9
insulin-like growth factor 9
FMR1 8
lacrimal 8
thyroid hormone 8
ATP 8
mast cell 8
IL-2 8
ESR 8
leptin 7
CBT 7
IL-4 7
parathyroid hormone 7
TNF-alpha 7
somatostatin 7
catalase 7
NMR 7
NMDA receptor 7
CRH 7
sit 7
ANA 7
nerve growth factor 7
5-HTTLPR 6
glucocorticoid receptor 6
cytochrome P450 6
5-HT2A 6
reserved 6
CYP2D6 6
corticotropin-releasing factor 6
sodium channel 6
MOS 6
olfactory 6
IL-17 5
SMD 5
Cytokine 5
peroxidase 5
fibrinogen 5
Mot 5
Gen 5
alkaline phosphatase 5
interferon-alpha 5
IL-5 5
serotonin receptor 5
calcium channel 5
ADHD 5
tumor necrosis factor alpha 5
TMD 5
xenobiotic 5
eotaxin 5
TLR4 5
N-acetylaspartate 4
PCS 4
chemokine 4
IFN 4
scratch 4
B19 4
San 4
glucosamine 4
glutathione peroxidase 4
OPRM1 4
Met 4
fragile X mental retardation protein 4
MRS 4
CYP 4
adrenocorticotropic hormone 4
MPD 4
axonal 4
Growth hormone 4
ERK 4
superoxide dismutase 4
cage 4
IL-1RA 4
FMRP 4
tap 4
oxytocin 4
RDC 4
ASIC3 4
CD4 4
IgE 4
creatine kinase 4
LBP 4
tryptophan hydroxylase 4
neuropeptide Y 4
ionotropic 4
MCS 4
Mal 4
albumin 3
MAO-A 3
CO2 3
FSS 3
thyrotropin-releasing hormone 3
adiponectin 3
TMS 3
anonymous 3
COX-2 3
RPE 3
myoglobin 3
nitric oxide synthase 3
PBS 3
GSH 3
IL-1 beta 3
CGI 3
FSH 3
MDD 3
VEGF 3
TRPV1 3
extracellular signal-regulated kinase 3
IL-2 receptor 3
CPM 3
COMT 3
amyloid precursor protein 3
Brain-derived neurotrophic factor 3
more...
Disease
fibromyalgia 4687
chronic pain 876
depression 792
rheumatoid arthritis 385
chronic fatigue syndrome 378
osteoarthritis 275
irritable bowel syndrome 262
arthritis 260
sleep disturbances 172
migraine 169
systemic lupus erythematosus 146
cognitive impairment 102
cold 90
sleep disorders 89
Best 88
major depressive disorder 88
psychological distress 78
anxiety disorders 76
diabetes 74
cancer 73
multiple sclerosis 72
rheumatism 71
ankylosing spondylitis 69
Myofascial pain syndrome 64
posttraumatic stress disorder 64
obesity 60
chronic disease 58
regional pain syndrome 55
hypertension 50
lupus 49
osteoporosis 49
neuropathy 49
asthma 46
Lyme disease 42
interstitial cystitis 41
mental illness 40
hypothyroidism 39
lupus 38
diabetic neuropathy 38
psoriatic arthritis 38
gout 36
postherpetic neuralgia 34
Alzheimer's disease 32
arthropathy 31
Parkinson's disease 31
emotional distress 30
epilepsy 30
vasculitis 30
autoimmune disease 28
peripheral neuropathy 27
confusion 27
tension headache 27
schizophrenia 27
musculoskeletal disease 26
hepatitis C 24
HIV 24
stroke 23
sexual abuse 23
polymyalgia rheumatica 23
endometriosis 23
inflammatory bowel disease 22
psoriasis 22
PSS 22
bipolar disorder 22
psychological stress 22
TMJ 21
sleep apnea 21
scleroderma 21
Frey 21
Myofascial pain 21
tendinitis 19
cardiovascular disease 19
affective disorder 19
Syndrome 18
bursitis 18
sexual dysfunction 18
tumor 17
suicide 17
connective tissue disease 17
panic disorder 17
addiction 17
infectious diseases 16
autism 16
influenza 16
xerostomia 16
restless legs syndrome 16
ICD 16
dementia 16
carpal tunnel syndrome 16
dysautonomia 15
type 2 diabetes 15
SLE 15
Raynaud's phenomenon 15
metabolic syndrome 14
ischemia 14
organic disease 14
breast cancer 14
Sjogren's syndrome 13
dyspepsia 13
Ehlers-Danlos syndrome 13
juvenile rheumatoid arthritis 13
celiac disease 13
Lupus 12
ADHD 12
synovitis 12
vitamin D deficiency 12
narcolepsy 12
myopathy 12
dermatomyositis 12
disinhibition 12
neuroticism 12
psychosis 12
myositis 12
polymyositis 11
pruritus 11
somatization disorder 11
emotional stress 11
virus infection 11
hypochondriasis 11
enthesitis 11
SEM 11
polyarthritis 11
heart failure 11
heart disease 11
reflex sympathetic dystrophy 11
HPA 11
Crohn's disease 11
gastroesophageal reflux disease 10
sick building syndrome 10
AIDS 10
phantom limb pain 10
trigeminal neuralgia 10
obsessive-compulsive disorder 10
alcoholism 10
memory impairment 10
spondyloarthropathy 9
sicca syndrome 9
West 9
leukemia 9
tenosynovitis 9
myocardial infarction 9
scoliosis 9
epicondylitis 9
spondylitis 9
Raynaud 9
chronic obstructive pulmonary disease 8
rumination 8
Beard 8
giant cell arteritis 8
binge eating 8
incontinence 8
gluten sensitivity 8
osteomalacia 8
hysteria 8
substance abuse 8
psychosomatic disorders 8
neurological disease 7
mitral valve prolapse 7
Epstein 7
bruxism 7
more...
Symptom
pain 2963
fatigue 905
headache 331
myalgia 209
low back pain 173
back pain 92
insomnia 80
analgesia 75
generalized pain 75
arthralgia 57
discomfort 46
neck pain 46
weakness 43
dizziness 40
pelvic pain 35
discomfort 34
sleepiness 34
nausea 33
facial pain 30
seizures 29
acute pain 29
body pain 28
paresthesia 27
abdominal pain 26
diarrhea 24
chest pain 23
spasm 23
overweight 22
alexithymia 22
shoulder pain 20
exhaustion 20
tinnitus 19
constipation 19
chronic back pain 19
cancer pain 18
tremor 18
ataxia 17
vomiting 17
muscle stiffness 15
neuralgia 14
erythema 13
numbness 13
stigma 12
anesthesia 12
vertigo 11
distraction 11
dyspnea 11
Ill 10
bladder pain 10
spasticity 9
asthenia 9
Depressive symptoms 9
syncope 9
dystonia 9
dental pain 8
joint stiffness 8
sciatica 8
dry eye 8
limb pain 8
orofacial pain 8
angina 8
Joint hypermobility 8
Tenderness 8
knee pain 8
acute stress 8
bone pain 7
memory loss 6
tingling 6
mental fatigue 5
flushing 5
sore throat 5
heartburn 5
agitation 5
Musculoskeletal symptoms 5
Neuropathic pain 5
blurred vision 4
Wind 4
hypersomnia 4
glossodynia 4
growing pains 4
bloating 4
epigastric pain 4
dysesthesia 4
stomach pain 4
physical exhaustion 4
chronic cough 4
Poor sleep 4
urinary frequency 4
forgetfulness 4
breakthrough pain 3
torticollis 3
mastalgia 3
myoclonus 3
swollen joints 3
physical symptom 3
snoring 3
arm pain 3
vestibulitis 3
leg pain 3
cough 3
dysuria 3
Multiple symptoms 3
nausea and vomiting 3
otalgia 2
Chronic pelvic pain 2
enuresis 2
hyperacusis 2
disturbed balance 2
rectal pain 2
Hudson 2
elbow pain 2
Diffuse pain 2
atypical chest pain 2
lightheadedness 2
muscle cramps 2
shortness of breath 2
Visceral pain 2
cerebellar ataxia 2
abdominal discomfort 2
colic 2
pallor 2
photophobia 2
Vulvodynia 2
lethargy 2
tense 2
hand pain 2
polymyalgia 2
eye pain 2
hot flushes 2
Exercise intolerance 2
rhinorrhea 2
despair 2
anorexia 2
leg cramps 2
hip pain 2
hypertonia 2
aphonia 1
Fatigability 1
bradykinesia 1
postnasal drip 1
fasciculation 1
cervical spine dysfunction 1
Muscle soreness 1
fever of unknown origin 1
flank pain 1
Other chronic pain 1
collapse 1
Muscle tenderness 1
hemiplegia 1
frequent urination 1
feeling tired 1
hepatomegaly 1
Localized pain 1
Acute back pain 1
livedo 1
blepharospasm 1
wheezing 1
chills 1
thinning 1
loss of feeling 1
more...
Drug
Pregabalin 50
Domperidone 35
Duloxetine 32
CFS 29
Ranitidine 10
Reserpine 10
CSF 9
IL-2 8
Asthma 6
Dermatol 6
ROC 5
Gabapentin 5
ascorbate 5
Growth hormone 4
Growth hormone 4
caffeine 4
TMS 3
ADM 3
BH4 3
Award 3
Spectrum 3
Mirtazapine 3
CPM 3
Monit 3
Flexeril 2
Nephron 2
DPA 2
Check 2
IFN-gamma 2
Fosamax 2
lactose 2
PPA 2
pyridoxal phosphate 2
Android 2
Spectrum 2
ENT 2
Tetrax 2
ROS 2
TRM 2
Gel 2
Portal 2
Ritanserin 1
Rituximab 1
Duloxetine hydrochloride 1
Prozac 1
Propidium 1
Elm 1
Salbutamol 1
Zoloft 1
Posture 1
ACT 1
Nabilone 1
ABC 1
EE2 1
Doxycycline 1
OIF 1
Hypaque 1
Tapentadol 1
Modafinil 1
Effexor 1
TES 1
Alosetron 1
DHT 1
Zonisamide 1
Celestone 1
PCP 1
Luteinizing 1
DHT 1
CAM 1
Ketalar 1
Pramipexole 1
Tryptophane 1
SPP 1
Bifidobacterium 1
9-THC 1
Tramal 1
nitroglycerin 1
Olive oil 1
lysine 1
Tramadol hydrochloride 1
TAK 1
niacin 1
Pramipexole 1
Ketalar 1
Nimesulide 1
Platelet Activating Factor 1
Fragment 1
Desvenlafaxine succinate 1
Moxifloxacin 1
Emodin 1
Denosumab 1
BoNT/A 1
Triad 1
GEO 1
THF 1
Tiaprofenic acid 1
Agomelatine 1
Cardiovasc 1
Albumin 1
NBT 1
Enzyme
ERK 63
monoamine oxidase 11
creatine kinase 9
catalase 7
superoxide dismutase 6
peroxidase 6
alkaline phosphatase 5
mitogen-activated protein kinase 5
protein kinase C 4
MCS 4
tryptophan hydroxylase 4
alanine aminotransferase 4
glutathione peroxidase 4
AMP-activated protein kinase 3
focal adhesion kinase 3
aspartate aminotransferase 3
CPM 3
prolyl endopeptidase 2
adenosine deaminase 2
elastase 2
transglutaminase 2
CFI 2
trypsin 2
CYP3A4 2
thyroid peroxidase 2
caspase-1 2
citrate synthase 2
protein kinase 2
AMPK 2
lactate dehydrogenase 2
AMPK 2
reverse transcriptase 2
adenosine deaminase 2
NAT 2
alpha-amylase 2
transaldolase 2
phosphodiesterase 2
ACE 2
SST 1
phospholipase C 1
ornithine decarboxylase 1
renin 1
ADE2 1
kyotorphin synthetase 1
peroxiredoxin 1
carbonic anhydrase 1
acetylcholinesterase 1
kallikrein 1
PCP 1
calcineurin 1
GTP cyclohydrolase I 1
pyruvate dehydrogenase 1
paraoxonase 1
cholinesterase 1
MIP 1
STR 1
neutrophil elastase 1
AOR 1
CD10 1
glutathione reductase 1
UDP-glucuronosyltransferase 1
glutathione S-transferase 1
collagenase 1
PGM 1
dipeptidyl peptidase IV 1
FAST 1
botulinum neurotoxin 1
5'-nucleotidase 1
CPS 1
phosphatidylinositol 3-kinase 1
lysozyme 1
CPT 1
aldehyde dehydrogenase 1
TPP 1
P-glycoprotein 1
proteasome 1
beta-glucuronidase 1
ACS 1
methylenetetrahydrofolate reductase 1
tryptase 1
CPT 1
CCS 1
CPT 1
thromboplastin 1
DAT 1
transketolase 1
methylenetetrahydrofolate reductase 1
AST 1
paraoxonase 1
lactase 1
ATPase 1
ceruloplasmin 1
monoacylglycerol lipase 1
TPP 1
tissue plasminogen activator 1
lipase 1
Rex 1
xanthine oxidase 1
lipoprotein lipase 1
Compound
Clin 765
Dec 321
5-HT 54
calcium 51
water 47
oxygen 46
noradrenaline 39
glutamate 35
DNA 34
tryptophan 33
tryptophan 32
tryptophan 32
tryptophan 32
sodium 29
vitamin D 24
nitric oxide 21
TNF 21
DSM 17
Amitriptyline 16
GABA 16
GABA 16
phosphate 16
coenzyme Q10 14
glucose 13
ACTH 12
gamma-aminobutyric acid 11
Vitamin D 10
Melatonin 10
methionine 10
Reserpine 10
adenosylmethionine 9
ATP 8
selenium 8
potassium 8
TSH 8
creatinine 8
ANA 7
NMDA 7
Coenzyme Q10 7
ANA 7
5-hydroxytryptophan 7
HAQ 6
Naltrexone 6
sulfate 6
phosphorus 6
iron 6
Cortisol 6
CES 6
Tropisetron 6
salt 6
glutamine 5
CO2 5
acetate 5
zinc 5
Thyroid 5
proline 5
Optimal 5
Ile 5
Malondialdehyde 5
hydroxyindoleacetic acid 5
Substance P 5
Ketamine 5
isoleucine 5
isoleucine 5
N-acetylaspartate 4
EDS 4
Phe 4
His 4
cysteine 4
serine 4
caffeine 4
arginine 4
valine 4
PGE2 4
Estrogen 4
phosphocreatine 4
Venlafaxine 4
hydrogen 4
Estrogen 4
leucine 4
ubiquinone 4
Tramadol 4
6-12 3
TOF 3
GSH 3
Lidocaine 3
phosphoric acid 3
5-HTP 3
GSH 3
homocysteine 3
aspartic acid 3
Morphine 3
Mirtazapine 3
5-HTP 3
tyrosine 3
SDS 3
mercury 3
Quetiapine 3
Pac 2
PPA 2
MEP 2
nitrogen 2
Sertraline 2
Dopamine 2
APS 2
Hearts 2
N-acetylcysteine 2
AMP 2
iodine 2
H2O2 2
HCl 2
Methylsulfonylmethane 2
alanine 2
SHB 2
silicon 2
silver 2
hyaluronic acid 2
25-Hydroxyvitamin D 2
L-carnitine 2
cadmium 2
ITP 2
NAD 2
Cardiol 2
copper 2
DHA 2
Bupropion 2
Flexeril 2
CoQ 2
PPA 2
TRH 2
R 2010 2
MDA 2
ADP 2
Mg2+ 2
acetic acid 2
CAM 2
formaldehyde 2
cAMP 2
Letter 2
Norepinephrine 2
neopterin 2
APAP 2
MEP 2
Adrenal 2
gamma-hydroxybutyric acid 1
TES 1
A 42 1
PAS 1
Piper 1
Lactate 1
C 10 1
L-T3 1
Doxycycline 1
Etanercept 1
lysine 1
Uric acid 1
Dimenhydrinate 1
Dextromethorphan 1
dipropyl 1
Gold, 1
more...