Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0016053 (
fibromyalgia
)
4,687
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Interleukin-2
(
IL-2
) production was studied in T lymphocytes and isolated CD4+ T lymphocytes from 12 patients with primary
fibromyalgia
syndrome and 10 healthy volunteers. The dose and time kinetics of
IL-2
production by concanavalin A-stimulated T cells and CD4+ T cells of
fibromyalgia
patients differed from findings in controls by 1) a need for a higher concentration of mitogen in order to achieve optimal
IL-2
secretion, and 2) a delay in the peak time of optimal
IL-2
secretion. Unlike normal
IL-2
secretion, which was higher after removal of CD8+ T cells, the pattern and degree of
IL-2
secretion by cells from
fibromyalgia
patients were not changed following removal of CD8+ T cells. Addition of calcium ionophore in assays using suboptimal concanavalin A concentrations did not correct the reduction in
IL-2
secretion by
fibromyalgia
patient T cells, but addition of phorbol myristate acetate induced normal secretion of
IL-2
. These findings suggest that there is a defect in the
IL-2
pathway, which is related to protein kinase C activation and does not involve impairment of Ca2+ elevation, in patients with
fibromyalgia
.
...
PMID:Altered interleukin-2 secretion in patients with primary fibromyalgia syndrome. 167 63
Fibromyalgia syndrome
(
FMS
) is now understood as a chronic pain syndrome, and recent evidence indicates it is not a pure psychosomatic disorder. We review the current knowledge in
FMS
pain pathways, focusing on the central system sensitization phenomenon and the abnormalities in the inhibitory pain systems. Chronic headache is one of the most common symptoms in
FMS
, and better knowledge of their common pathophysiologic features can help us understand both conditions better. These features include the nerve growth factor actions and failure of the endocannabinoid system. In addition, we review new immunological aspects of
FMS
, both in their humoral (autoantibodies, antipolymer antibodies) and cytokine (
interleukin-2
) aspects.
...
PMID:Fibromyalgia: an update and immunological aspects. 1876 35
