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Query: UMLS:C0016053 (fibromyalgia)
 4,687 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Chronic pain syndromes such as fibromyalgia and reflex sympathetic dystrophy constitute an increasing percentage of new patient referrals to pediatric rheumatology clinics. It is surprising then that so few studies have been published on these syndromes. This review focuses on the investigations that are central to our understanding of this difficult diagnostic area.
Curr Opin Rheumatol 1994 Sep
PMID:Progress in diagnosing and understanding chronic pain syndromes in children. 799 14

Previous studies have shown decreased voluntary muscle strength and endurance in patients with fibromyalgia. The aim of this study was to determine to what extent this is due to lack of exertion. The twitch interpolation technique was used to determine the degree of central activation and estimate the "true" quadriceps muscle strength in patients with fibromyalgia and age and sex matched controls. Subjects hereafter performed an endurance test consisting of repetitive contractions at 50% of estimated "true" muscle strength of four seconds duration followed by a six second rest until exhaustion, or maximally for 40 minutes. Twitch decline and increases in mean rectified EMG were used as objective markers of fatigue. The estimated "true" muscle strength was 82 (SD 26) Nm in 20 patients with fibromyalgia compared with 133 Nm (SD 28) Nm in the 21 controls (p < 0.001). The "true" muscle strength per cm2 midthigh cross sectional area was lower 0.50 (SD 0.15) Nm/cm2 in the patients compared with 0.74 (SD 0.15) Nm/cm2 in the controls (p < 0.001). The decline over time in twitch sizes was similar in the two groups. The mean rectified EMG signal at a fixed force level of 50% of "true" muscle strength increased similarly in the two groups. Relaxation rates and contraction rates also increased equally in the two groups. In conclusion, a reduction of the estimated muscle strength per area unit of about 35% was found in the patients with fibromyalgia. This might be secondary to physical inactivity or neuroendocrine factors. No differences in changes in the neurophysiological indices associated with fatigue were found between the two groups.
J Neurol Neurosurg Psychiatry 1994 Sep
PMID:Muscle strength, voluntary activation, twitch properties, and endurance in patients with fibromyalgia. 808 79

Fibromyalgia is regarded a state of pain that can both be triggered and maintained by a broad spectre of events, ranging from massive psychogenic stress to long-lasting excessive somatic strain. Based on a review of selected studies supported by the Norwegian Medical Research Council, this paper focuses on muscular exercise and related pain, the functional significance of certain neuropeptides, the contribution of the sympathetic nervous system and the psychological aspects of the condition.
Tidsskr Nor Laegeforen 1993 Sep 20
PMID:[Fibromyalgia--a relationship between psyche and soma?]. 821 97

The etiopathogenesis of primary fibromyalgia still remains an enigma to modern medicine. Several hypotheses have been suggested during the last years, and these are reviewed.
Tidsskr Nor Laegeforen 1993 Sep 20
PMID:[Etiological aspects of fibromyalgia]. 821 98

Clinical practice is characterized by having to make numerous important decisions, including the diagnosis. In this study, general practitioners were asked to agree or to disagree with statements of fibromyalgia. The main purpose was to test the usefulness of two well-known models for decision-making when studying diagnosis in cases of uncertainty and scepticism. The results show that the models are inadequate to explain the decisions.
Tidsskr Nor Laegeforen 1993 Sep 20
PMID:[Diagnostic rationalism. Views of general practitioners on fibromyalgia]. 821 6

Fibromyalgia is a chronic illness characterized by widespread pain, fatigue, sleep disturbance, and resistance to treatment. The purpose of this study was to evaluate the effectiveness of a meditation-based stress reduction program on fibromyalgia. Seventy-seven patients meeting the 1990 criteria of the American College of Rheumatology for fibromyalgia took part in a 10-week group outpatient program. Therapists followed a carefully defined treatment approach and met weekly to further promote uniformity. Patients were evaluated before and after the program. Initial evaluation included a psychiatric structured clinical interview (SCID). Outcome measures included visual analog scales to measure global well-being, pain, sleep, fatigue, and feeling refreshed in the morning. Patients also completed a medical symptom checklist, SCL-90-R, Coping Strategies Questionnaire, Fibromyalgia Impact Questionnaire, and the Fibromyalgia Attitude Index. Although the mean scores of all the patients completing the program showed improvement, 51% showed moderate to marked improvement and only they were counted as "responders." These preliminary findings suggest that a meditation-based stress reduction program is effective for patients with fibromyalgia.
Gen Hosp Psychiatry 1993 Sep
PMID:The impact of a meditation-based stress reduction program on fibromyalgia. 830 41

Major findings in the understanding of the epidemiology of systemic lupus erythematosus and in the description and understanding of its presentation and course in individual organ systems are reviewed. The role of serologic tests as correlates of disease activity remains controversial. No consensus has been reached on the association of either corticosteroid dose or of antiphospholipid antibodies with avascular necrosis of bone. Multiple rare presentations of cutaneous lupus have been reviewed during the past year. The role of hormones in the activity of lupus and the use of hormonal agents in the treatment of lupus are rapidly expanding and contentious areas of research. Cognitive function deficit continues to be an area of great interest, with studies differing on whether psychiatric disorders or organic lupus (or both) are responsible. Finally, fatigue and the potential role of fibromyalgia as an explanation for "lupus fatigue," are of major interest.
Curr Opin Rheumatol 1995 Sep
PMID:Clinical features of systemic lupus erythematosus. 851 12

Chronic fatigue syndrome (CFS) is an illness characterized by disabling fatigue associated with complaints of fevers, sore throat, myalgia, lymphadenopathy, sleep disturbances, neurocognitive difficulties, and depression. A striking feature of CFS is its sudden onset following an acute, presumably viral, illness and the subsequent recurrent "flu-like" symptoms. It has been speculated that both CFS and debilitating chronic fatigue (CF) that does not meet strict criteria for CFS may be the direct or indirect result of viral infections. We therefore tested 548 chronically fatigued patients who underwent a comprehensive medical and psychiatric evaluation for antibodies to 13 viruses. Our objectives were to compare the seroprevalence and/or geometric mean titer (GMT) of antibodies to herpes simplex virus 1 and 2, rubella, adenovirus, human herpesvirus 6, Epstein-Barr virus, cytomegalovirus, and Cox-sackie B virus, types 1-6 in patients with CF to healthy control subjects. Other goals were to determine if greater rates of seropositivity or higher GMTs occurred among subsets of patients with CFS, fibromyalgia, psychiatric disorders, a self-reported illness onset with a viral syndrome, and a documented temperature > 37 degrees C on physical examination. Differences in the seroprevalence or GMTs of antibodies to 13 viruses were not consistently found in those with CF compared with control subjects, or in any subsets of patients including those with CFS, an acute onset of illness, or a documented fever. These particular viral serologies were not useful in evaluating patients presenting with CF.
J Med Virol 1996 Sep
PMID:Viral serologies in patients with chronic fatigue and chronic fatigue syndrome. 889 37

This study examined the factors influencing the use of complementary therapies in patients with fibromyalgia. A postal questionnaire was sent to 90 patients who had attended a rheumatology out-patient clinic in West Yorkshire for their diagnosis or treatment of fibromyalgia. Seventy-one percent of fibromyalgia patients had used or were using complementary therapies. Patients who were using complementary therapies were of a higher socio-economic group (p < 0.001). The most popular therapy was oral supplementation. The duration of complementary therapies ranged from 3 months to 26 years (median = 3). The number of therapies used by each patient ranged from 1 to 10 (median = 3). The duration of fibromyalgia was associated with both the duration of complementary therapies (p < 0.001) and the number of therapies used (p < 0.05). The most popular source of advice for the decision to use complementary therapies was from a magazine (40%). Patients using complementary therapies were less likely to be satisfied with their current hospital treatment and turned to complementary therapies in the chance of relief from their fibromyalgia. The relatively high cost and lack of information on complementary therapies appeared to dissuade those patients who chose not to use it.
Clin Rheumatol 1996 Sep
PMID:Factors predisposing to the resort of complementary therapies in patients with fibromyalgia. 889 61

Forty-four fibromyalgia patients were followed through 4.5 years to assess the extent to which symptom duration, physical activity level, disability pensions, and the occurrence of critical life events would predict long-term outcome. Outcome measures included pressure tenderness (dolorimeter score), work capacity (ergometer cycle test), global subjective improvement (verbal rating scale), and visual analogue scale ratings of pain, disturbed sleep, lack of energy, and depression. Significant outcome predictors were identified by means of separate multiple regression analyses on each outcome measure at follow-up, using symptom duration, physical activity level, disability pension status, and occurrence of critical life events as independent variables, together with baseline symptom intensity and age, which were adjusted for. An adequate physical activity level and increasing age predicted a positive outcome, while receiving a permanent disability pension or having experienced an excess of major negative life events predicted a negative outcome. Symptom duration did not affect outcome.
J Psychosom Res 1996 Sep
PMID:Fibromyalgia outcome: the predictive values of symptom duration, physical activity, disability pension, and critical life events--a 4.5 year prospective study. 891 Feb 46


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