Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0016053 (
fibromyalgia
)
4,687
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Interleukin-2
(
IL-2
) production was studied in T lymphocytes and isolated CD4+ T lymphocytes from 12 patients with primary
fibromyalgia
syndrome and 10 healthy volunteers. The dose and time kinetics of
IL-2
production by concanavalin A-stimulated T cells and CD4+ T cells of
fibromyalgia
patients differed from findings in controls by 1) a need for a higher concentration of mitogen in order to achieve optimal
IL-2
secretion, and 2) a delay in the peak time of optimal
IL-2
secretion. Unlike normal
IL-2
secretion, which was higher after removal of CD8+ T cells, the pattern and degree of
IL-2
secretion by cells from
fibromyalgia
patients were not changed following removal of CD8+ T cells. Addition of calcium ionophore in assays using suboptimal concanavalin A concentrations did not correct the reduction in
IL-2
secretion by
fibromyalgia
patient T cells, but addition of phorbol myristate acetate induced normal secretion of
IL-2
. These findings suggest that there is a defect in the
IL-2
pathway, which is related to protein kinase C activation and does not involve impairment of Ca2+ elevation, in patients with
fibromyalgia
.
...
PMID:Altered interleukin-2 secretion in patients with primary fibromyalgia syndrome. 167 63
