Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0016053 (fibromyalgia)
 4,687 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A patient with facial pain of 1 1/2 years' duration, associated with limitation of opening of the mouth, click, and osteodegenerative changes of the temporomandibular joint, was initially thought to be suffering from a myofascial pain dysfunction syndrome. At first, the patient reacted favorably to muscle exercises and an antidepressive drug, but reduced lacrimation and the development of deafness on the affected side led to re-evaluation and a diagnosis of nasopharyngeal tumor. Biopsy confirmed the presence of an adenocarcinoma of the nasopharynx. The variability of symptoms and the diagnostic problems presented by this tumor are discussed.
 ...
PMID:Nasopharyngeal tumor initially manifested as myofascial pain dysfunction syndrome. 19 39

The oral health of twenth-two patients with a diagnosis of myofascial pain dysfunction syndrome was evaluated. Radiographs, photographs, study casts, visual and digital clinical examinations, hematologic data, blood pressure, and periodontal examinations were used with each patient. A review of the literature indicated a variety of causes for facial pain, including Costen's syndrome, muscle fatique and spasm, occlusion, and psychogenic factors. This study revealed the following trends: (1) The periodontal health of patients with the myofascial pain dysfunction syndrome appears to be better than anticipated. (2) Bruxism accounts for a healthy dental apparatus when other diseases are not present. (3) Groups of muscles, other than the masticatory group, may contribute to the myofascial pain dysfunction syndrome. (4) Patients presented with various ranges of malocclusions and normal occlusions, deep overbites and overjets, complete dentitions, and missing teeth (either equally missing right and left or unequally missing right and left). This article also discusses clinical considerations in the diagnosis of the myofascial pain dysfunction syndrome and offers a practical, physiologic approach to treatment. We conclude that how one uses his mandible is more of a causative factor than the relationships of the teeth.
 ...
PMID:Oral considerations of the myofascial pain dysfunction syndrome. 106 26

In the last 30 years antidepressant drugs have been used increasingly in the treatment of patients with chronic pain. This article reviews the results of some 40 placebo-controlled studies. It is difficult to make comparisons between the various studies because they often differ in terms of pain conditions, patient selection, antidepressant drug used, dosages, trial design, etc. However, in spite of this heterogeneity and other methodological problems it is clear that a wide range of pain conditions are responsive to antidepressant drug treatment, in particular: headache, migraine, facial pain, neurogenic pain, fibrositis, and probably arthritis and rheumatoid arthritis. More data need to be gathered in cancer pain, and in other conditions such as low back pain for which no, or very limited, effect has been shown. The beneficial effects of antidepressant drugs is in most cases of a mild to moderate degree, some time lag is necessary before it is completely manifest, and it tends to persist over time if drug treatment is continued in the long term. Strong evidence of efficacy is not evident for all the antidepressants, and there are probably significant differences in this respect between various drugs. The effect of a drug on pain does not seem necessarily to be related to its effect on mood. Further studies are needed to clarify this topic, and it will be necessary to examine specific pain conditions, compare different antidepressants, with reference to each other and to placebo, further investigate the role of drug plasma concentrations and control for the presence of concomitant psychiatric disturbances and for organic lesions responsible for the pain symptomatology.
 ...
PMID:The use of antidepressants in the treatment of chronic pain. A review of the current evidence. 172 71

Orofacial pain can have an inflammatory, neurologic or musculoskeletal cause. Inflammatory diseases include dental abscess, sinusitis, temporal arteritis, sialolithiasis and infections of the parotid gland. Common neurologic diseases that cause facial pain are trigeminal neuralgia, glossopharyngeal neuralgia, paratrigeminal neuralgia and cluster headaches. Musculoskeletal causes include temporomandibular joint syndrome and myofascial pain dysfunction syndrome. A clear understanding of pertinent anatomy and an organized approach to diagnosis will facilitate the evaluation of patients with orofacial pain.
 ...
PMID:Orofacial pain: diagnosis and treatment. 136 Jul 64

Myofascial pain and dysfunction is the primary diagnosis in a large proportion of facial pain complaints. Myofascial disease can present in the form of trigger points, fibromyositis, myositis, muscle spasm, and muscle weakness. The purpose of this study is to research for quantifiable physiological differences between groups of normal subjects and myofascial pain dysfunction (MPD) patients. The first specific aim was to determine the opening of the jaw at which maximal isometric tension can be produced by the jaw closing muscles, with the hypothesis that this opening of maximal tension would be less for a group of MPD patients than for a group of normal subjects being tested. The second aim was to test the hypothesis that the maximal isometric bite forces for the two groups would differ. Patients with mandibular dysfunction are reported to have a lower maximal bite than normal subjects. Bite force was measured with the T-Scan system. An 80 micron horseshoe-shaped sensor connected to a dedicated IBM XT computer recorded the data. A self-contained printer produced the hard copy for later analysis. Vertical dimension or jaw opening was increased in 0.5-mm increments using double flat plane appliances standardized by the Relator. A MANOVA was used for statistical analysis of the data. MPD patients had significantly higher bite forces at 8.0, 8.5, 9, and 9.5 mm. Normal subjects had higher force values at 5.0 mm. There was no significant difference in mean maximal bite force between groups.
 ...
PMID:Length-tension relations of the masticatory elevator muscles in normal subjects and pain dysfunction patients. 207 94

Patients with chronic pain are often depressed, and antidepressants have been widely used in the treatment of these patients. Well controlled clinical studies have shown that antidepressants have analgesic effects, apparently independent of changes in mood, and in lower doses than used in the treatment of depression. Good results have been reported for several types of chronic pain, especially headache and facial pain, arthritis, fibromyalgia and neuralgias. In addition, antidepressants have also an indirect analgesic action by relieving a depressive condition associated with chronic pain.
 ...
PMID:[Do antidepressive agents have analgesic effects?]. 221 95

Myofascial pain dysfunction syndrome and temporomandibular joint (TMJ) dysfunction syndrome have been suggested as resulting from masticatory muscle hyperactivity. Furthermore, this hyperactivity has been viewed as a response-specific reaction to stress. The present study was designed to assess the effects of laboratory-induced stress (i.e., startle stimulus, buzzer series, serial sevens tasks, and pain threshold/tolerance tests) on physiological responses (i.e. bilateral masseter EMG, skin conductance level, and heart rate) of ten patients (TMJ pain) with a history of facial pain and TMJ sounds. The two control groups, one with TMJ sounds only (TMJ sound) and the other with no history of these symptoms (non-TMJ), were matched for sex and age. The results indicated that the TMJ pain group did not exhibit different masseter EMG levels when comparing symptomatic versus asymptomatic sides. Few significant differences were noted in the masseter EMG recordings of the TMJ pain and non-TMJ group, while no difference occurred between the EMG levels of the TMJ pain and TMJ sound group. Little support was found for the assertion that TMJ pain subjects show greater EMG reactivity and less adaptation than do non-TMJ subjects. Finally, no differences were found among groups in relation to the latency to ischaemic pain onset or tolerance. The discussion focuses on reasons for the findings of the present study being discrepant from previously reported research.
 ...
PMID:Physiological reactions to stress in subjects with and without myofascial pain dysfunction symptoms. 658 75

By virtue of referral patterns, the otolaryngologist is in a position to be of considerable influence in the treatment of numerous patients with facial pain. In a facial pain clinic, the 525 consecutive patients seen could be classified into groups: myofascial pain dysfunction syndrome (52.9%); degenerative arthritis of the temporomandibular joints (16.6%); trigeminal neuralgia (15.3%); and a variety of other pain syndromes (15.2%). The most frequent types of health professionals contacted were, in decreasing order, dentists, general medical practitioners, otolaryngologists, and neurologists. The greatest number of consultations with all physicians resulted in either no treatment or referral. This was most common among otolaryngologists, and least among dentists and neurologists. Specific treatment, when provided, varied by specialty.
 ...
PMID:Treatment of patients with temporomandibular joint and other facial pain by otolaryngologists. 705 9

A variety of conditions are frequently associated with the occurrence of head and neck pain. The purposes of this review are: to describe the characteristics of several musculoskeletal, neurological, and systemic conditions frequently cited as possible causes of head and neck pain and to suggest a new technique for treating head and neck pain. The characteristics of musculoskeletal conditions, such as muscle spasm, tendinitis, trigger points, and joint inflammation, and their relationship to head and neck pain are considered. The features and clinical implications of neurologic conditions, such as atypical facial pain, trigeminal and glossopharyngeal neuralgia, reflex sympathetic dystrophy, and neurogenic inflammation, are also described. The distinguishing characteristics of headaches, including cluster, tension, chronic daily, rebound, posttraumatic, and postlumbar puncture, are detailed. This review also addresses the contributions of systemic disorders, such as osteoarthritis, rheumatoid arthritis and the variants, and rheumatoid-related conditions, like dermatomyositis, temporal arteritis, Lyme's disease, and fibromyalgia, to head and neck pain. The results of a recent pilot study of the effectiveness of intraoral circulating ice water for resolving symptoms related to head and neck pain secondary to neurogenic inflammation are presented in this work. Ice water circulating through hollow metal tubes was placed intraorally for 15 minutes in the posterior maxillary area on 12 individuals with cervical pain and muscle spasm. In nine of these individuals, reduced cervical pain perception, upper trapezius electromyography signal reduction, and increased cervical range of motion was produced. Six out of 12 individuals had accompanying headache, which was reduced or eliminated in four cases. These findings suggest a strong trigemino-cervical relationship to neck pain and headache.
 ...
PMID:Head and neck pain review: traditional and new perspectives. 889 41

Myofascial pain syndrome of the head and neck is a frequent cause of facial pain and is characterized by tender trigger points. In a double-blind study of 107 patients, local injection therapy using one of three solutions was applied at the trigger points by intracutaneous injection of 0.3 ml solution followed by deep infiltration of the site. Results using bupivacaine 0.25%, lignocaine 1% and saline 0.9% were compared. There was no significant difference among groups with respect to reduction of pain and overall rating by patients of the therapeutic benefits. Fifty-three patients (49%) were free of symptoms after treatment, 40 patients (38%) reported substantial relief and in 14 patients (13%) symptoms remained unchanged. The findings suggest that relief of pain is mainly due to reflex mechanisms rather than to the pharmacological effects of the injected solutions. Physiological saline solution is recommended for use in local injection therapy.
 ...
PMID:Local injection therapy in 107 patients with myofascial pain syndrome of the head and neck. 895 38


1 2 3 Next >>