Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0016053 (fibromyalgia)
 4,687 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The antidepressant efficacy of fluoxetine in major depression has been briefly reviewed. A brief outline of dose selection, therapeutic onset, and pharmacokinetics of fluoxetine were made. The potential use of the drug in management of various psychiatric conditions has been examined. These include obsessive-compulsive disorder and related variances, anorexia nervosa, bulimia nervosa, Tourette's syndrome, and trichotillomania. The suggested use of fluoxetine in pain relief in certain diabetics, premenstrual syndrome, and migraine headache were assessed. The reports on the use of fluoxetine in panic disorders, paraphilias, and related conditions and in the management of substance abuse, alcoholism, and cocaine abuse, were summarized and elaborated upon. A composite of preliminary reports cited in literature pertinent to the potential of fluoxetine in treatment of abusing injurious behavior, dysthymic disorder, fibrositis, postanoxicaction myoclonus, pathologic jealously, personality disorder, pseudobulbar affect, and social phobia were also reviewed. Fluoxetine pharmacological profile may be extended to cover a relative wide range of application, provided future controlled studies confirm the preliminary data found in the literature.
 ...
PMID:Fluoxetine: a spectrum of clinical applications and postulates of underlying mechanisms. 830 48

In an attempt to identify diagnostically meaningful subgroups in a group of sixty women 18-34 years of age, 19 of them having a DSM-IV diagnosis of anorexia nervosa and 41 of bulimia nervosa, a hierarchical cluster analysis was performed on their data obtained from the Defense Mechanism Technique modified (DMTm) and the Eating Disorder Inventory (EDI). Variables also taken into account in the cluster analysis were those of the main diagnosis, depression, personality disorder, binge eating, purging, Body Mass Index (BMI), and exercise. Five distinct clusters were found. Six of the eight EDI variables and fourteen of the twenty DMTm variables were represented in the description of the clusters. One anorexic and one bulimic cluster included DMTm signs previously found in patients with fibromyalgia. Two bulimic clusters included DMTm signs previously observed in patients with either distal or total ulcerative colitis. Hysteria was linked with the remaining anorexic cluster. On both EDI and DMTm the two main groups of anorexic and bulimic patients displayed few differences. It was mainly the various constellations of DMTm variables, interpreted in terms of the Andersson developmental and psychodynamic model of the mind, that were crucial for understanding the five clusters obtained.
 ...
PMID:An attempt at distinguishing subgroups of women with anorexia nervosa and bulimia nervosa by means of the Defense Mechanism Technique modified (DMTm) and the Eating Disorder Inventory (EDI). 1627 40

Depression is a prominent feature in fibromyalgia syndrome. Patients with fibromyalgia syndrome who are obese, with poor sleep quality, and those who have recurrent episodes of binge eating are at greater risk to develop depression. The aim of this cross-sectional study was to examine the hypothesis that the relationship between obesity and depression in patients with primary fibromyalgia syndrome is mediated by poor sleep, binge eating disorder (BED), and weight and shape concern. This study included 131 patients with primary fibromyalgia syndrome. Participants completed the following questionnaires: Pittsburgh Sleep Quality Index, Beck Depression Inventory-II, Eating Disorder questionnaire, and Fibromyalgia Impact Questionnaire. Body mass index (BMI) provided the primary indicator of obesity. Sobel test showed that the conditions for complete mediation were satisfied on the weight and shape concern as mediator between BMI and depression because the association between BMI and depression score became insignificant after controlling of weight and shape concern. However, since the association between BMI and depression remained significant after BED and poor sleep score were controlled, thus for both mediators, the conditions for partial mediation on the depression were satisfied. The findings suggest that in patients with primary fibromyalgia syndrome, weight and shape concern, BED, and poor sleep quality are important mediators of the relationship between obesity and depression. We suggest that a greater focus on these mediators in depression treatment may be indicated.
 ...
PMID:Depression in obese patients with primary fibromyalgia: the mediating role of poor sleep and eating disorder features. 2320 22