Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0016053 (fibromyalgia)
 4,687 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Ten female and 2 male patients with chronic hepatitis C infection had fibromyalgia as a prominent musculoskeletal problem. In 9 patients, the fibromyalgia developed a mean of 13.4 years after the hepatitis C infection. In 2 patients, the 2 diseases occurred within weeks to a few months of each other, and in 1 patient, preexisting fibromyalgia was apparently aggravated by the hepatitis C infection. All patients had a possible blood or body fluid exposure event or high risk activity: intravenous blood products in 3, occupational needle stick in 1, tattoos in 3, intravenous drug use in 3 and promiscuous sexual practices in 2. Transaminases were moderately elevated in 10 patients, and chronic active hepatitis was found in 4 patients who were biopsied. All patients had prominent fatigue. Additional features not commonly seen in fibromyalgia patients included fluctuating synovitis in 5 patients, biopsy-proven leukocytoclastic vasculitis in 5, sicca symptoms in 3, Raynaud's phenomenon in 3, and cryoglobulinemia in 2. One patient died in multi-organ failure after treatment for systemic vasculitis. Rheumatologists and internists should be aware that patients with hepatitis C infection can have fibromyalgia that occurs concomitantly with other extrahepatic manifestations of hepatitis C.
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PMID:Fibromyalgia: a prominent feature in patients with musculoskeletal problems in chronic hepatitis C: a report of 12 patients. 1907 62

Fibromyalgia (FM) is a syndrome characterized by widespread and chronic musculoskeletal pain, fatigue, morning stiffness, and sleep disturbance. However, the etiopathogenesis of FM remains unclear. Various etiological factors have been suggested to trigger FM. These include systemic rheumatismal disease, physical trauma, psychological disorders, and chronic infections. We determined the prevalence of FM in patients with chronic active hepatitis B virus (HBV) and inactive hepatitis B carriers, compared with matched healthy controls. Seventy-seven HBV patients (39 HBV carriers and 38 with chronic active hepatitis), were evaluated for FM syndrome. Seventy-seven HBsAg-negative healthy subjects were enrolled as a control group. We found that FM was very prevalent in patients with HBV infections (22% of the total). We found no difference in FM prevalence when patients with chronic active hepatitis B infections (21% FM prevalence) and those who were inactive hepatitis B carriers (23% FM prevalence) were compared. FM was not associated with the levels of HBV-DNA, ALT, or AST. Recognition and management of FM in HBsAg-positive patients will aid in improvement of quality-of-life. We fully accept that our preliminary results require confirmation in studies including larger numbers of patients. More work is needed to allow us to understand the role played by, and the relevance of, infections (including HBV) in FM syndrome pathogenesis.
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PMID:The prevalence of fibromyalgia among patients with hepatitis B virus infection. 2417 75