Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0016053 (fibromyalgia)
 4,687 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The article presents a one-year material of 41 women and 59 men with chronic low-back disorders. Patients who had undergone back surgery and patients with inflammatory disease, fibromyalgia and somatoform disorders were excluded. Median age was 39 years, and median time off work was 16 months. Neurological deficits were found in the lower extremities in 48%. Of the 48 patients with calf symptoms, 60% had neurological deficits. Of 22 patients with thigh symptoms, 45% had neurological deficits, and such deficits were found in 30% of the 30 patients with back pain only. Relevant roentgenographic findings were obtained in 84%; decreased disc height, osteoarthritic facet joints, end-plate fracture, narrow bony canal, disc bulge and disc prolapse. It is concluded that, in the evaluation of low-back disorders, survey x-ray examination is a valuable and necessary supplement to a detailed history and thorough clinical examination.
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PMID:[Symptoms and findings in chronic low back pain. Significance of symptom localization and radiographic findings]. 252 86

We evaluated the prevalence of hepatitis C virus (HCV) infection in Italian patients suffering from fibromyalgia (FM), in comparison with patients affected by non-HCV related rheumatic degenerative disorders. Consecutive patients with FM and a statistically comparable group of patients suffering from peripheral osteoarthritis (OA) or sciatica due to L4-L5 or L5-S1 herniated disc were tested for HCV infection with a third-generation microparticle enzyme immunoassay (MEIA). In the positive cases, a third-generation recombinant immunoblot assay (RIBA) confirmatory test and serum HCV-RNA test were performed. Fisher's exact test was performed to compare the prevalence of HCV infection (MEIA- and RIBA-positive results) obtained in the two enrolled groups. Enrolled were 152 subjects suffering from FM and 152 patients with peripheral OA or sciatica. Anti-HCV antibodies were found in 7/152 (4.6%) patients suffering from FM and in 5/152 (3.3%) of control subjects. No statistically significant differences in HCV prevalence were detected between cases and controls. Our present report does not confirm previous data indicating an increased prevalence of HCV in FM patients and does not seem to support a significant pathogenetic role of HCV under this condition.
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PMID:Hepatitis C virus infection in Italian patients with fibromyalgia. 1794 29