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Query: UMLS:C0016053 (fibromyalgia)
 4,687 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The purpose of this study was to evaluate the relationship between hypermobility and fibromyalgia syndrome (FS) in women. Ninety-three women with FS who met the American College of Rheumatology criteria for FS and 58 healthy women without FS were included in this study. All women were examined for hypermobility by blinded observers using the Beighton criteria. The mean age was 43.5+/-9.9 (21-68) and 40.2+/-11.1 (21-63) years in the FS and control groups, respectively, and the two groups were statistically similar (p>0.05). The mean Beighton total score was 4.7+/-2.1 and 2.9+/-2.4 in the FS and control groups, respectively (p<0.0001). The frequency of joint hypermobility was 64.2% in the FS group and 22% in the control group. In accordance with the Beighton criteria (p<0.05), we found that the joint hypermobility ratio was significantly higher in patients with FS than in subjects without FS. Additionally, we evaluated the correlation between the total Beighton score and the age and number of trigger points. There were negative correlations between the total Beighton score and the age (r=-0.42, p<0.001) and number of trigger points (r=-0.24, p=0.03) in all patients. Hypermobility syndrome is more common in women with FS than in those in the control group. Therefore, the relationship between hypermobility and FS should be taken into consideration in the diagnosis and follow-up of women, especially those with widespread pain.
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PMID:Hypermobility in women with fibromyalgia syndrome. 1622 25

Hypermobility denotes an increased range of joint movements and is the result of ligamentous and joint capsule laxity. Benign joint hypermobility syndrome is hypermobility associated with symptoms--arthralgia, myalgia, fatigue, anxiety and fibromyalgia. Clinical manifestations of benign joint hypermobility syndrome include almost all organic systems, and reflect the ubiquity of connective tissue in the body. Beighton score help us to diagnoses hypermobility. Hypermobility syndrome is diagnosed using the 1998 "Brighton criteria". The purpose of this case report was to emphasize the importance of recognition hypermobility syndrome because such individuals represent a significant percentage patients who seek help of different specialist and because of the diversity of the clinical presentation very long stay unrecognized (undiagnosed). Hypermobility can be easily detected if you are looking for, but is easily overlooked if you do not think about it.
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PMID:[Benign joint hypermobility syndrome--a case report: unrecognized or undiagnosed condition?]. 2094 40

Fibromyalgia syndrome (FMS) is a common and intriguing condition, manifest by chronic pain and fatigue. Although the pathogenesis of FMS is not yet completely understood, predicting the future development of FMS and chronic pain is a major challenge with great potential advantages, both from an individual as well as an epidemiological standpoint. Current knowledge indicates a genetic underpinning for FMS, and as increasing data are accumulated regarding the genetics involved, the prospect of utilizing these data for prediction becomes ever more attractive. The co-existence of FMS with multiple other functional disorders indicates that the clinical identification of such symptom constellations in a patient can alert the physician to the future development of FMS. Hypermobility syndrome is another clinical (as well as genetic) phenotype that has emerged as a risk factor for the development of FMS. Stressful events, including early life trauma, are also harbingers of the future development of FMS. Functional neuroimaging may help to elucidate the neural processes involved in central sensitization, and may ultimately also evolve into markers of predictive value. Last but not least, obesity and disturbed sleep are clinical (inter-related) features relevant for this spectrum. Future efforts will aim at integrating genetic, clinical and physiological data in the prediction of FMS and chronic pain.
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PMID:Predicting fibromyalgia, a narrative review: are we better than fools and children? 2461 70