Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0016053 (fibromyalgia)
 4,687 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Myalgia is a complaint associated with numerous medical conditions such as metabolic or hormonal abnormalities, toxic myopathies, tetanus, electrolyte disturbances, inflammatory diseases, and exertion-related pain. A diagnosis of tension myalgia or myofascial-type pain is often considered when no objective findings are seen in the evaluation. This is a report of a patient who was treated unsuccessfully for fibromyalgia for many years and who ultimately was diagnosed with a rare benign skeletal muscle metabolic disorder caused by myoadenylate deaminase deficiency. We discuss this enzyme deficiency and its importance for the physiatric community.
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PMID:Tension myalgia versus myoadenylate deaminase deficiency: a case report. 901 67

To determine whether altered cellular immune response might mediate the increased health risks associated with social inhibition, we examined delayed type hypersensitivity (DTH) responses in 36 adults under conditions of low and high intensity social engagement. Participants come from a study of psychological factors in functional bowel disease and fibromyalgia. Under high engagement conditions, socially inhibited individuals showed significantly increased induration in response to intradermal tetanus toxoid. Under low engagement conditions, these individuals showed less pronounced DTH responses that did not differ in magnitude from those of uninhibited individuals. This pattern of results was found using two different measures of social inhibition and was independent of social inhibition's definition as a continuously distributed trait vs a discrete category. These data are consistent with the general hypothesis that social inhibition represents a predisposition to physiologic hyperresponsiveness that requires an exogenous social trigger for expression.
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PMID:Socially inhibited individuals show heightened DTH response during intense social engagement. 1037 81