Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0015695 (
fatty liver
)
13,941
document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds)
.
Concepts found in the documents ranked by [
Frequency
|
Pointwise Mutual Information
|
Symmetric Conditional Probability
] .
Human Gene/Protein
insulin
3742
Sep
810
Mol
728
alanine aminotransferase
580
gut
514
leptin
438
aspartate aminotransferase
429
endoplasmic reticulum
413
adiponectin
400
peroxisome proliferator-activated receptor
379
fatty acid synthase
354
tumor necrosis factor
303
TNF
280
cytokine
264
HDL
260
AMP-activated protein kinase
249
AST
224
AMPK
204
collagen
199
sterol regulatory element-binding protein
183
PPAR
180
IL-6
176
glucagon
176
ATP
175
acetyl-CoA carboxylase
172
epididymal
163
SREBP-1c
159
superoxide dismutase
155
peroxisome proliferator-activated receptor gamma
152
GSH
144
albumin
128
alkaline phosphatase
126
microsomal
126
nuclear receptor
120
lipopolysaccharide
116
stearoyl-CoA desaturase
114
C-reactive protein
112
mTOR
110
interleukin-6
109
adipokine
109
hemoglobin
107
TLR4
106
PNPLA3
104
SREBP-1
103
FAS
101
CD36
101
apolipoprotein B
97
catalase
93
MRI
89
JNK
89
cytochrome P450
86
lipoprotein lipase
85
farnesoid X receptor
85
microsomal triglyceride transfer protein
84
caspase-3
83
AKT
83
insulin receptor
81
NAD
80
interferon
79
peroxisome proliferator-activated receptor alpha
79
carnitine palmitoyltransferase
78
IRS-1
75
glutathione peroxidase
75
PGC
73
ROS
71
perilipin
70
CYP2E1
68
She
68
Nrf2
67
uncoupling protein 1
67
Leptin
66
ACC
66
Fibroblast growth factor 21
65
ferritin
64
SCD1
63
NMR
63
SOD
61
SIRT1
61
AMP
61
reductase
61
more...
Disease
fatty liver
13941
obesity
3794
cirrhosis
1889
diabetes
1858
liver disease
1642
metabolic syndrome
1592
type 2 diabetes
1277
Nonalcoholic fatty liver
1177
hepatocellular carcinoma
1130
alcoholic fatty liver
931
dyslipidemia
696
cancer
638
chronic liver disease
618
hypertension
550
hyperlipidemia
545
cardiovascular disease
514
liver fibrosis
512
hepatitis
446
atherosclerosis
432
glucose intolerance
419
hepatitis C
419
hyperglycemia
418
chronic hepatitis
373
hyperinsulinemia
298
viral hepatitis
268
tumor
265
hepatitis B
237
liver cancer
227
alcoholic hepatitis
193
hypercholesterolemia
191
cholestasis
190
liver cancer
188
lipodystrophy
160
GSH
144
hypoglycemia
134
alcohol abuse
118
ischemia
117
preeclampsia
116
metabolic disorder
115
malnutrition
109
gallstones
106
FAS
104
HIV
99
alcoholic cirrhosis
94
HELLP syndrome
94
carcinogenesis
93
ketosis
90
alcoholism
89
virus infection
86
Hepatocellular carcinoma
85
cold
76
polycystic ovary syndrome
74
portal hypertension
74
Alcoholic liver disease
74
carcinoma
73
stroke
73
tumorigenesis
71
primary biliary cirrhosis
71
chronic active hepatitis
68
iron overload
68
coronary heart disease
67
pancreatitis
66
generalized lipodystrophy
63
abdominal obesity
63
hyperphagia
63
overnutrition
62
hemochromatosis
59
immunodeficiency
58
obstructive sleep apnea
55
depression
55
hepatic encephalopathy
54
sepsis
54
inflammatory bowel disease
54
hyperuricemia
53
cardiomyopathy
53
coronary artery disease
53
renal disease
51
heart failure
50
osteoporosis
50
breast cancer
50
more...
Symptom
overweight
290
hepatomegaly
176
starvation
68
vomiting
65
diarrhea
54
abdominal pain
49
fatigue
41
nausea
39
hyperemesis gravidarum
35
splenomegaly
32
anesthesia
28
pain
25
seizures
25
anorexia
22
weakness
18
polyuria
14
Ill
14
polydipsia
13
cachexia
11
lethargy
10
hepatosplenomegaly
10
hypoproteinemia
10
collapse
9
constipation
9
nausea and vomiting
9
ketonuria
8
epigastric pain
8
respiratory distress
8
hypotonia
7
hypothermia
7
headache
7
discomfort
6
discomfort
6
ataxia
6
dyspnea
6
exhaustion
5
arthralgia
4
right upper quadrant pain
4
asthenia
4
erythema
4
thinning
4
cerebellar ataxia
4
angina
4
sleepiness
4
acute stress
3
emaciation
3
bloating
3
abdominal discomfort
3
memory loss
3
Cushingoid
3
hunger
3
hypercapnia
3
Cushingoid
3
myalgia
3
stigma
3
Decreased activity
3
hyperemesis
2
HSA
2
Stiffness
2
syncope
2
tremor
2
menopausal symptoms
2
Spots
2
acidity
2
oliguria
2
acute abdomen
2
paresis
2
prostration
2
exertional dyspnea
2
analgesia
2
Wind
2
chronic constipation
2
clubbing
2
corpulence
1
intestinal bleeding
1
bitter taste
1
knee pain
1
abdominal fullness
1
night sweats
1
Skin symptoms
1
more...
Drug
vitamin E
112
Ethanol
107
ROS
71
Fructose
60
lysine
54
NADH
54
Kenyan
42
Glucagon
31
Cardiovasc
29
niacin
22
ascorbate
22
ROC
20
Bifidobacterium
20
Monit
19
Vitamin E
18
Ezetimibe
17
Dermatol
17
Portal
16
caffeine
16
EPA
14
Rosiglitazone
13
Liraglutide
13
CAM
13
ALA
13
Exenatide
11
Albumin
11
Growth hormone
11
Leaf
10
Growth hormone
10
Glutathione
10
CCL
9
PCB
8
citric acid
8
Glycyrrhiza
7
Vitamin A
7
CSF
7
IFN-gamma
7
EE2
6
Fluorescein
6
IL-2
6
MAP
6
lactose
6
Bezafibrate
6
Estrogens
5
Sorafenib
5
Alanine
5
TAK
5
Rimonabant
5
DMI
5
Isoniazid
5
ADM
5
Parkin
4
Activin
4
Propofol
4
Tacrolimus
4
Histamine
4
Orlistat
4
Creosote
4
Ginseng
4
p75
4
Parkin
4
Glycerol
3
Red ginseng
3
linolenate
3
Olmesartan
3
Heme
3
AZT
3
CDX
3
CDX
3
Retinoic acid
3
AZT
3
Bortezomib
3
Clofibrate
3
Indomethacin
3
Oxaliplatin
3
Metreleptin
3
Rutin
3
Gd-BOPTA
3
Simvastatin
3
Myricetin
3
more...
Enzyme
alanine aminotransferase
1030
aspartate aminotransferase
640
AMP-activated protein kinase
434
AST
224
mitogen-activated protein kinase
211
superoxide dismutase
207
AMPK
206
AMPK
204
protein kinase
203
acetyl-CoA carboxylase
182
gamma-glutamyl transpeptidase
171
CPT
131
alkaline phosphatase
128
catalase
110
lipoprotein lipase
90
glutathione peroxidase
81
lipase
74
ERK
71
luciferase
67
CPT
56
CPT
56
caspase-3
54
phosphoenolpyruvate carboxykinase
52
diacylglycerol acyltransferase
50
phosphoenolpyruvate carboxykinase
43
phosphoenolpyruvate carboxykinase
43
acyl-CoA oxidase
43
lactate dehydrogenase
43
focal adhesion kinase
39
reverse transcriptase
39
hormone-sensitive lipase
39
protein kinase C
38
glucose-6-phosphatase
37
CYP7A1
37
ATPase
35
acyl-CoA dehydrogenase
33
complex I
32
NADPH oxidase
30
NADPH oxidase
30
cholinesterase
30
alcohol dehydrogenase
29
glucokinase
28
aldehyde dehydrogenase
27
proteasome
27
peroxidase
27
glutamate dehydrogenase
26
glutamate dehydrogenase
26
glutamate dehydrogenase
26
acetylcholinesterase
26
phosphatidylinositol 3-kinase
25
renin
25
glutathione S-transferase
24
glucose-6-phosphate dehydrogenase
23
creatine kinase
22
ACS
21
aldehyde dehydrogenase
21
pyruvate carboxylase
21
acyl-CoA synthetase
21
pyruvate kinase
19
3-hydroxyacyl-CoA dehydrogenase
19
aldehyde dehydrogenase
19
glutathione reductase
19
GSK
19
phospholipase A2
19
CYP3A4
19
aldehyde dehydrogenase
19
aldehyde dehydrogenase
19
LPL
18
collagenase
18
MEK
18
caspase-1
17
ceruloplasmin
17
cholesterol acyltransferase
16
phosphatidylethanolamine N-methyltransferase
16
citrate synthase
16
ACE
15
AMP-activated kinase
15
acyl-CoA dehydrogenase
15
NO synthase
15
IKK
14
more...
Compound
glucose
2380
Clin
972
Dec
834
ethanol
698
oxygen
479
water
431
DNA
402
methionine
369
Insulin
314
TNF
280
iron
181
palmitic acid
177
ATP
175
CoA
172
palmitic acid
158
GSH
150
GSH
150
phosphate
149
glycerol
135
calcium
126
sodium
121
Oil Red O
110
Oil Red O
102
NAD
101
alanine
99
NAD
80
acetate
79
betaine
76
galactose
73
AMP
68
homocysteine
68
vitamin D
64
nitric oxide
63
adenosylmethionine
63
Fructose
61
Cholesterol
60
lysine
59
nitrogen
59
serine
59
aldehyde
59
tyrosine
58
cysteine
57
nicotinamide
56
CPT
56
urea
56
CPT
56
arginine
55
NADH
54
glutamate
53
CCl4
53
salt
52
FFA
52
MDA
47
acetaldehyde
47
creatinine
46
silver
46
zinc
44
cAMP
43
His
43
leucine
43
copper
42
PMA
42
hydrogen
40
retinol
40
tryptophan
38
tryptophan
38
acetyl-CoA
38
Metformin
37
Metformin
37
Choline
35
GPT
35
threonine
35
tryptophan
35
tryptophan
35
ammonia
35
CO2
34
Resveratrol
32
Hematoxylin
31
Glucagon
31
NADPH
30
more...