Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0015695 (
fatty liver
)
13,941
document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds)
.
Concepts found in the documents ranked by [
Frequency
|
Pointwise Mutual Information
|
Symmetric Conditional Probability
] .
Human Gene/Protein
insulin
3742
Sep
810
Mol
728
alanine aminotransferase
580
gut
514
leptin
438
aspartate aminotransferase
429
endoplasmic reticulum
413
adiponectin
400
peroxisome proliferator-activated receptor
379
fatty acid synthase
354
tumor necrosis factor
303
TNF
280
cytokine
264
HDL
260
AMP-activated protein kinase
249
AST
224
AMPK
204
collagen
199
sterol regulatory element-binding protein
183
PPAR
180
glucagon
176
IL-6
176
ATP
175
acetyl-CoA carboxylase
172
epididymal
163
SREBP-1c
159
superoxide dismutase
155
peroxisome proliferator-activated receptor gamma
152
GSH
144
albumin
128
microsomal
126
alkaline phosphatase
126
nuclear receptor
120
lipopolysaccharide
116
stearoyl-CoA desaturase
114
C-reactive protein
112
mTOR
110
adipokine
109
interleukin-6
109
hemoglobin
107
TLR4
106
PNPLA3
104
SREBP-1
103
CD36
101
FAS
101
apolipoprotein B
97
catalase
93
JNK
89
MRI
89
cytochrome P450
86
farnesoid X receptor
85
lipoprotein lipase
85
microsomal triglyceride transfer protein
84
caspase-3
83
AKT
83
insulin receptor
81
NAD
80
peroxisome proliferator-activated receptor alpha
79
interferon
79
carnitine palmitoyltransferase
78
IRS-1
75
glutathione peroxidase
75
PGC
73
ROS
71
perilipin
70
She
68
CYP2E1
68
Nrf2
67
uncoupling protein 1
67
ACC
66
Leptin
66
Fibroblast growth factor 21
65
ferritin
64
NMR
63
SCD1
63
SOD
61
SIRT1
61
inducible nitric oxide synthase
61
reductase
61
AMP
61
adipose triglyceride lipase
60
apolipoprotein
59
phospholipase
58
LXR
58
sterol regulatory element-binding protein-1c
57
acyl-CoA oxidase
56
CPT
56
HMG-CoA reductase
55
phosphatase
54
p38
54
NADH
54
erythroid
53
growth hormone
53
diacylglycerol acyltransferase
53
GGT
52
p62
52
TNF-alpha
52
tumor necrosis factor alpha
51
hemochromatosis
51
Adiponectin
50
casein
50
long chain
49
lipase
49
xenobiotic
49
chemokine
48
p53
48
low-density lipoprotein receptor
48
MCP-1
48
C18
48
resistin
47
heme oxygenase-1
46
cytochrome P450 2E1
46
PI3K
46
SREBP-2
46
histone
45
phosphoenolpyruvate carboxykinase
45
sirtuin 1
45
STAT3
45
glucose transporter
44
Bcl-2
44
core protein
44
CHOP
44
p65
43
carnitine palmitoyltransferase 1
43
FABP
42
FIB
42
SCD
42
SMA
42
IL-10
42
GLP-1 receptor
42
thyroid hormone
41
protein kinase B
41
c-Jun
41
CYP7A1
40
MAPK
40
serum albumin
40
gamma-glutamyltransferase
39
apoB-100
39
ERK
39
hormone-sensitive lipase
39
peptidase
39
plasminogen activator inhibitor-1
39
gamma-glutamyl transpeptidase
39
monocyte chemoattractant protein-1
38
cytochrome
38
lactate dehydrogenase
38
apoE
37
LC3
37
glucose-6-phosphatase
37
Fas
37
glycoprotein
37
LPS
37
LDL receptor
37
Peroxisome proliferator-activated receptor
36
GPT
35
UCP2
35
DGAT2
35
leptin receptor
35
peroxisome proliferator activated receptor
35
more...
Disease
fatty liver
13941
obesity
3794
cirrhosis
1889
diabetes
1858
liver disease
1642
metabolic syndrome
1592
type 2 diabetes
1277
Nonalcoholic fatty liver
1177
hepatocellular carcinoma
1130
alcoholic fatty liver
931
dyslipidemia
696
cancer
638
chronic liver disease
618
hypertension
550
hyperlipidemia
545
cardiovascular disease
514
liver fibrosis
512
hepatitis
446
atherosclerosis
432
hepatitis C
419
glucose intolerance
419
hyperglycemia
418
chronic hepatitis
373
hyperinsulinemia
298
viral hepatitis
268
tumor
265
hepatitis B
237
liver cancer
227
alcoholic hepatitis
193
hypercholesterolemia
191
cholestasis
190
liver cancer
188
lipodystrophy
160
GSH
144
hypoglycemia
134
alcohol abuse
118
ischemia
117
preeclampsia
116
metabolic disorder
115
malnutrition
109
gallstones
106
FAS
104
HIV
99
HELLP syndrome
94
alcoholic cirrhosis
94
carcinogenesis
93
ketosis
90
alcoholism
89
virus infection
86
Hepatocellular carcinoma
85
cold
76
polycystic ovary syndrome
74
Alcoholic liver disease
74
portal hypertension
74
carcinoma
73
stroke
73
primary biliary cirrhosis
71
tumorigenesis
71
chronic active hepatitis
68
iron overload
68
coronary heart disease
67
pancreatitis
66
generalized lipodystrophy
63
hyperphagia
63
abdominal obesity
63
overnutrition
62
hemochromatosis
59
immunodeficiency
58
depression
55
obstructive sleep apnea
55
hepatic encephalopathy
54
sepsis
54
inflammatory bowel disease
54
hyperuricemia
53
cardiomyopathy
53
coronary artery disease
53
renal disease
51
heart failure
50
breast cancer
50
sepsis
50
osteoporosis
50
acute hepatitis
48
lipidosis
47
plaque
46
encephalopathy
46
lactic acidosis
46
chronic disease
45
morbid obesity
45
metastases
45
hypothyroidism
44
sickle cell disease
43
malabsorption
42
SCD
42
anemia
41
prediabetes
41
Alzheimer's disease
41
primary sclerosing cholangitis
40
choline deficiency
40
type 1 diabetes
39
chronic persistent hepatitis
39
lipid disorder
39
myopathy
39
thrombocytopenia
38
eclampsia
37
Reye's syndrome
37
coagulopathy
37
Acute fatty liver of pregnancy
37
cholangitis
36
disseminated intravascular coagulation
36
proteinuria
36
AIDS
35
acute pancreatitis
34
renal failure
33
MRS
33
Evans
32
colorectal cancer
31
heart disease
31
Cirrhosis
31
Wilson's disease
31
sleep apnea
31
myocardial infarction
31
hypobetalipoproteinemia
29
asthma
29
systemic lupus erythematosus
28
celiac disease
28
neuropathy
27
infectious diseases
27
hyperhomocysteinemia
27
Syndrome
26
HCC
26
psoriasis
26
Crohn's disease
26
pruritus
26
hemangioma
25
ABL
25
rheumatoid arthritis
25
AIN
25
coma
24
atherosclerotic cardiovascular disease
24
myocardial ischemia
24
lipoatrophy
24
adenocarcinoma
24
liver metastases
24
Best
24
LDLR
24
Brown
22
vascular disease
22
vitamin D deficiency
22
hyperandrogenism
21
acanthosis nigricans
21
Adenovirus
21
acute alcoholic hepatitis
21
cystic fibrosis
20
retinopathy
20
Chronic hepatitis C
20
pancreatic cancer
20
gout
20
gastroesophageal reflux disease
20
chronic pancreatitis
19
adenoma
19
more...
Symptom
overweight
290
hepatomegaly
176
starvation
68
vomiting
65
diarrhea
54
abdominal pain
49
fatigue
41
nausea
39
hyperemesis gravidarum
35
splenomegaly
32
anesthesia
28
seizures
25
pain
25
anorexia
22
weakness
18
Ill
14
polyuria
14
polydipsia
13
cachexia
11
hepatosplenomegaly
10
hypoproteinemia
10
lethargy
10
collapse
9
constipation
9
nausea and vomiting
9
epigastric pain
8
respiratory distress
8
ketonuria
8
hypotonia
7
headache
7
hypothermia
7
dyspnea
6
ataxia
6
discomfort
6
discomfort
6
exhaustion
5
arthralgia
4
right upper quadrant pain
4
asthenia
4
thinning
4
erythema
4
cerebellar ataxia
4
angina
4
sleepiness
4
acute stress
3
emaciation
3
memory loss
3
stigma
3
Cushingoid
3
Cushingoid
3
myalgia
3
hunger
3
hypercapnia
3
abdominal discomfort
3
bloating
3
Decreased activity
3
hyperemesis
2
HSA
2
Stiffness
2
syncope
2
tremor
2
Spots
2
acidity
2
Wind
2
analgesia
2
prostration
2
oliguria
2
acute abdomen
2
paresis
2
exertional dyspnea
2
menopausal symptoms
2
chronic constipation
2
clubbing
2
corpulence
1
intestinal bleeding
1
bitter taste
1
knee pain
1
abdominal fullness
1
night sweats
1
Skin symptoms
1
hypersomnia
1
abnormal gait
1
fever of unknown origin
1
insomnia
1
flushing
1
POA
1
BHS
1
vertigo
1
heartburn
1
Postoperative pain
1
breath holding
1
intestinal angina
1
abdominal cramps
1
chills
1
swollen penis
1
Appetite suppression
1
functional recovery
1
hot flushes
1
agitation
1
snoring
1
intestinal pain
1
apathy
1
decreased appetite
1
epigastric distress
1
ophthalmoplegia
1
pelvic pain
1
No adverse effect
1
low back pain
1
breast hyperplasia
1
muscle cramps
1
tonic-clonic seizure
1
cough
1
chronic cough
1
productive cough
1
dizziness
1
Drug
vitamin E
112
Ethanol
107
ROS
71
Fructose
60
NADH
54
lysine
54
Kenyan
42
Glucagon
31
Cardiovasc
29
ascorbate
22
niacin
22
ROC
20
Bifidobacterium
20
Monit
19
Vitamin E
18
Ezetimibe
17
Dermatol
17
Portal
16
caffeine
16
EPA
14
Rosiglitazone
13
Liraglutide
13
CAM
13
ALA
13
Exenatide
11
Growth hormone
11
Albumin
11
Leaf
10
Growth hormone
10
Glutathione
10
CCL
9
PCB
8
citric acid
8
IFN-gamma
7
Vitamin A
7
Glycyrrhiza
7
CSF
7
EE2
6
Bezafibrate
6
Fluorescein
6
MAP
6
IL-2
6
lactose
6
Isoniazid
5
Estrogens
5
TAK
5
Alanine
5
DMI
5
ADM
5
Rimonabant
5
Sorafenib
5
Tacrolimus
4
Parkin
4
Ginseng
4
Histamine
4
Activin
4
Propofol
4
Creosote
4
Parkin
4
p75
4
Orlistat
4
AZT
3
CDX
3
DHT
3
Heme
3
Olmesartan
3
Retinoic acid
3
DHT
3
Glycerol
3
Red ginseng
3
Metreleptin
3
Bortezomib
3
Gd-BOPTA
3
AZT
3
Rutin
3
Clofibrate
3
Simvastatin
3
linolenate
3
Myricetin
3
Oxaliplatin
3
Indomethacin
3
TAC
3
CDX
3
Dial
3
Irinotecan
2
RFP
2
Lipitor
2
ENT
2
PMPA
2
Asn
2
Colestimide
2
Citrus unshiu peel
2
Wine
2
pyridoxal phosphate
2
Malotilate
2
Diurnal
2
NVP
2
Triclosan
2
Serum albumin
2
Angiotensin II
2
ZnO
2
ETS
2
nitroglycerin
2
Lipitor
2
Cilostazol
2
Riboflavin
2
Captopril
2
Ginger
2
Schisandra fruit
2
Tenofovir
2
Olive oil
2
Lipitor
2
Pravastatin
2
OTC
2
Fraction
2
Gel
2
Paraffin
2
IL-1ra
2
Aloe
2
Award
2
Vitamin B12
2
ampicillin
2
OTC
2
Ringer's solution
2
FAD
2
Emodin
2
THF
2
Coconut oil
2
Levovist
2
Epigallocatechin
2
Emodin
2
Indocyanine green
1
1-Deoxynojirimycin
1
Platelet concentrate
1
Vitamin B
1
Asthma
1
CTX
1
Proglumide
1
Sevelamer
1
Trifluoperazine
1
Diphenhydramine
1
ABC
1
Apomorphine
1
2-Methoxyestradiol
1
SNL
1
Cidofovir
1
Entecavir
1
Itraconazole
1
Photofrin
1
Coral
1
Antithrombin III
1
CDP
1
Escitalopram
1
Mirtazapine
1
TTC
1
Casodex
1
Valsartan
1
Carbenoxolone
1
NOV
1
Biopolymers
1
more...
Enzyme
alanine aminotransferase
1030
aspartate aminotransferase
640
AMP-activated protein kinase
434
AST
224
mitogen-activated protein kinase
211
superoxide dismutase
207
AMPK
206
AMPK
204
protein kinase
203
acetyl-CoA carboxylase
182
gamma-glutamyl transpeptidase
171
CPT
131
alkaline phosphatase
128
catalase
110
lipoprotein lipase
90
glutathione peroxidase
81
lipase
74
ERK
71
luciferase
67
CPT
56
CPT
56
caspase-3
54
phosphoenolpyruvate carboxykinase
52
diacylglycerol acyltransferase
50
phosphoenolpyruvate carboxykinase
43
lactate dehydrogenase
43
acyl-CoA oxidase
43
phosphoenolpyruvate carboxykinase
43
reverse transcriptase
39
focal adhesion kinase
39
hormone-sensitive lipase
39
protein kinase C
38
CYP7A1
37
glucose-6-phosphatase
37
ATPase
35
acyl-CoA dehydrogenase
33
complex I
32
cholinesterase
30
NADPH oxidase
30
NADPH oxidase
30
alcohol dehydrogenase
29
glucokinase
28
proteasome
27
peroxidase
27
aldehyde dehydrogenase
27
acetylcholinesterase
26
glutamate dehydrogenase
26
glutamate dehydrogenase
26
glutamate dehydrogenase
26
phosphatidylinositol 3-kinase
25
renin
25
glutathione S-transferase
24
glucose-6-phosphate dehydrogenase
23
creatine kinase
22
ACS
21
aldehyde dehydrogenase
21
acyl-CoA synthetase
21
pyruvate carboxylase
21
pyruvate kinase
19
glutathione reductase
19
aldehyde dehydrogenase
19
GSK
19
CYP3A4
19
phospholipase A2
19
3-hydroxyacyl-CoA dehydrogenase
19
aldehyde dehydrogenase
19
aldehyde dehydrogenase
19
LPL
18
collagenase
18
MEK
18
ceruloplasmin
17
caspase-1
17
phosphatidylethanolamine N-methyltransferase
16
cholesterol acyltransferase
16
citrate synthase
16
ACE
15
acyl-CoA dehydrogenase
15
AMP-activated kinase
15
NO synthase
15
phosphoinositide 3-kinase
14
succinate dehydrogenase
14
IKK
14
phosphodiesterase
14
lecithin:cholesterol acyltransferase
14
calcineurin
14
3-hydroxyacyl-CoA dehydrogenase
13
RNA polymerase
13
heme oxygenase
13
soluble epoxide hydrolase
13
thrombin
12
fructokinase
12
xanthine oxidase
12
isocitrate dehydrogenase
11
paraoxonase
11
3-hydroxy-3-methylglutaryl-CoA reductase
11
acyl-CoA synthetase
11
paraoxonase
11
UDP-glucuronosyltransferase
10
glycerol kinase
10
pyruvate dehydrogenase
10
HMG-CoA synthase
10
cystathionine beta-synthase
10
arginase
10
PARP
9
ketohexokinase
9
fatty-acid synthase
9
NQO1
9
caspase-9
9
demethylase
9
glycerol-3-phosphate dehydrogenase
9
hexokinase
9
glutamine synthetase
9
cytochrome oxidase
9
aldose reductase
9
ECH
9
acid phosphatase
9
isocitrate dehydrogenase
8
PDK1
8
malate dehydrogenase
8
type III procollagen
8
thromboplastin
8
ATP synthase
8
phosphatidate phosphatase
8
BAT
7
acyl-CoA thioesterase
7
glycerol-3-phosphate dehydrogenase
7
carboxylesterase
7
aldolase
7
cathepsin B
7
transpeptidase
7
methylenetetrahydrofolate reductase
7
glycerophosphate acyltransferase
7
methylenetetrahydrofolate reductase
7
ornithine transcarbamylase
7
fatty acid elongase
7
trypsin
7
betaine-homocysteine methyltransferase
7
nicotinamide phosphoribosyltransferase
6
TSA
6
CPR
6
sorbitol dehydrogenase
6
prolyl hydroxylase
6
DNA polymerase
6
gamma-glutamylcysteine synthetase
6
lipoxygenase
6
beta-glucuronidase
6
peroxiredoxin
5
pyruvate dehydrogenase
5
cdc2
5
fatty acid desaturase
5
pyruvate dehydrogenase
5
cathepsin D
5
phospholipase D
5
AOR
5
CAD
5
diaphorase
5
caspase-2
5
argininosuccinate synthetase
5
11beta-hydroxysteroid dehydrogenase
5
transcriptase
5
more...
Compound
glucose
2380
Clin
972
Dec
834
ethanol
698
oxygen
479
water
431
DNA
402
methionine
369
Insulin
314
TNF
280
iron
181
palmitic acid
177
ATP
175
CoA
172
palmitic acid
158
GSH
150
GSH
150
phosphate
149
glycerol
135
calcium
126
sodium
121
Oil Red O
110
Oil Red O
102
NAD
101
alanine
99
NAD
80
acetate
79
betaine
76
galactose
73
AMP
68
homocysteine
68
vitamin D
64
nitric oxide
63
adenosylmethionine
63
Fructose
61
Cholesterol
60
lysine
59
serine
59
aldehyde
59
nitrogen
59
tyrosine
58
cysteine
57
CPT
56
nicotinamide
56
urea
56
CPT
56
arginine
55
NADH
54
glutamate
53
CCl4
53
salt
52
FFA
52
acetaldehyde
47
MDA
47
creatinine
46
silver
46
zinc
44
His
43
cAMP
43
leucine
43
copper
42
PMA
42
retinol
40
hydrogen
40
tryptophan
38
tryptophan
38
acetyl-CoA
38
Metformin
37
Metformin
37
tryptophan
35
ammonia
35
threonine
35
Choline
35
GPT
35
tryptophan
35
CO2
34
Resveratrol
32
Glucagon
31
Hematoxylin
31
NADPH
30
NADPH
30
Cardiol
29
alcohol dehydrogenase
29
ALP
28
DHA
28
L-carnitine
28
ADP
28
GSSG
27
Pac
27
Pioglitazone
27
N-acetylcysteine
27
sulfate
27
ADP
26
malonyl-CoA
26
S-adenosylhomocysteine
26
ADP
26
glutamine
26
DHA
24
DHA
24
NADP
23
Curcumin
23
Vitamin E
22
selenium
22
Ile
21
ACS
20
ACS
20
aldehyde
20
Tamoxifen
19
Tamoxifen
19
Oleic acid
19
Sodium
19
adenylate
19
palmitoyl-CoA
18
pentose
18
CAT
18
Thyroid
18
isoleucine
17
TOF
17
Conjugated linoleic acid
17
pentose
17
CAT
17
pentose
17
phosphorus
17
CAT
17
MTT
17
pentose
17
Melatonin
16
isoleucine
16
hyaluronic acid
16
GTP
16
retinoic acid
16
caffeine
16
stearic acid
15
Methionine
15
DPP
15
Estrogen
15
valine
15
TCA
15
Gly
15
Estrogen
15
Phe
15
nicotinic acid
15
methanol
14
Vitamin D
14
uridine
14
pyrimidine
14
8-OHdG
14
potassium
14
manganese
14
pyrimidine
14
aldosterone
14
H2O2
14
EPA
14
Acyl-CoA
13
Triton
13
TSH
13
acetone
13
stearic acid
13
stearic acid
13
Ursodeoxycholic acid
13
more...