Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0015695 (fatty liver)
13,941 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
insulin 3742
Sep 810
Mol 728
alanine aminotransferase 580
gut 514
leptin 438
aspartate aminotransferase 429
endoplasmic reticulum 413
adiponectin 400
peroxisome proliferator-activated receptor 379
fatty acid synthase 354
tumor necrosis factor 303
TNF 280
cytokine 264
HDL 260
AMP-activated protein kinase 249
AST 224
AMPK 204
collagen 199
sterol regulatory element-binding protein 183
PPAR 180
glucagon 176
IL-6 176
ATP 175
acetyl-CoA carboxylase 172
epididymal 163
SREBP-1c 159
superoxide dismutase 155
peroxisome proliferator-activated receptor gamma 152
GSH 144
albumin 128
microsomal 126
alkaline phosphatase 126
nuclear receptor 120
lipopolysaccharide 116
stearoyl-CoA desaturase 114
C-reactive protein 112
mTOR 110
adipokine 109
interleukin-6 109
hemoglobin 107
TLR4 106
PNPLA3 104
SREBP-1 103
CD36 101
FAS 101
apolipoprotein B 97
catalase 93
JNK 89
MRI 89
cytochrome P450 86
farnesoid X receptor 85
lipoprotein lipase 85
microsomal triglyceride transfer protein 84
caspase-3 83
AKT 83
insulin receptor 81
NAD 80
peroxisome proliferator-activated receptor alpha 79
interferon 79
carnitine palmitoyltransferase 78
IRS-1 75
glutathione peroxidase 75
PGC 73
ROS 71
perilipin 70
She 68
CYP2E1 68
Nrf2 67
uncoupling protein 1 67
ACC 66
Leptin 66
Fibroblast growth factor 21 65
ferritin 64
NMR 63
SCD1 63
SOD 61
SIRT1 61
inducible nitric oxide synthase 61
reductase 61
AMP 61
adipose triglyceride lipase 60
apolipoprotein 59
phospholipase 58
LXR 58
sterol regulatory element-binding protein-1c 57
acyl-CoA oxidase 56
CPT 56
HMG-CoA reductase 55
phosphatase 54
p38 54
NADH 54
erythroid 53
growth hormone 53
diacylglycerol acyltransferase 53
GGT 52
p62 52
TNF-alpha 52
tumor necrosis factor alpha 51
hemochromatosis 51
Adiponectin 50
casein 50
long chain 49
lipase 49
xenobiotic 49
chemokine 48
p53 48
low-density lipoprotein receptor 48
MCP-1 48
C18 48
resistin 47
heme oxygenase-1 46
cytochrome P450 2E1 46
PI3K 46
SREBP-2 46
histone 45
phosphoenolpyruvate carboxykinase 45
sirtuin 1 45
STAT3 45
glucose transporter 44
Bcl-2 44
core protein 44
CHOP 44
p65 43
carnitine palmitoyltransferase 1 43
FABP 42
FIB 42
SCD 42
SMA 42
IL-10 42
GLP-1 receptor 42
thyroid hormone 41
protein kinase B 41
c-Jun 41
CYP7A1 40
MAPK 40
serum albumin 40
gamma-glutamyltransferase 39
apoB-100 39
ERK 39
hormone-sensitive lipase 39
peptidase 39
plasminogen activator inhibitor-1 39
gamma-glutamyl transpeptidase 39
monocyte chemoattractant protein-1 38
cytochrome 38
lactate dehydrogenase 38
apoE 37
LC3 37
glucose-6-phosphatase 37
Fas 37
glycoprotein 37
LPS 37
LDL receptor 37
Peroxisome proliferator-activated receptor 36
GPT 35
UCP2 35
DGAT2 35
leptin receptor 35
peroxisome proliferator activated receptor 35
more...
Disease
fatty liver 13941
obesity 3794
cirrhosis 1889
diabetes 1858
liver disease 1642
metabolic syndrome 1592
type 2 diabetes 1277
Nonalcoholic fatty liver 1177
hepatocellular carcinoma 1130
alcoholic fatty liver 931
dyslipidemia 696
cancer 638
chronic liver disease 618
hypertension 550
hyperlipidemia 545
cardiovascular disease 514
liver fibrosis 512
hepatitis 446
atherosclerosis 432
hepatitis C 419
glucose intolerance 419
hyperglycemia 418
chronic hepatitis 373
hyperinsulinemia 298
viral hepatitis 268
tumor 265
hepatitis B 237
liver cancer 227
alcoholic hepatitis 193
hypercholesterolemia 191
cholestasis 190
liver cancer 188
lipodystrophy 160
GSH 144
hypoglycemia 134
alcohol abuse 118
ischemia 117
preeclampsia 116
metabolic disorder 115
malnutrition 109
gallstones 106
FAS 104
HIV 99
HELLP syndrome 94
alcoholic cirrhosis 94
carcinogenesis 93
ketosis 90
alcoholism 89
virus infection 86
Hepatocellular carcinoma 85
cold 76
polycystic ovary syndrome 74
Alcoholic liver disease 74
portal hypertension 74
carcinoma 73
stroke 73
primary biliary cirrhosis 71
tumorigenesis 71
chronic active hepatitis 68
iron overload 68
coronary heart disease 67
pancreatitis 66
generalized lipodystrophy 63
hyperphagia 63
abdominal obesity 63
overnutrition 62
hemochromatosis 59
immunodeficiency 58
depression 55
obstructive sleep apnea 55
hepatic encephalopathy 54
sepsis 54
inflammatory bowel disease 54
hyperuricemia 53
cardiomyopathy 53
coronary artery disease 53
renal disease 51
heart failure 50
breast cancer 50
sepsis 50
osteoporosis 50
acute hepatitis 48
lipidosis 47
plaque 46
encephalopathy 46
lactic acidosis 46
chronic disease 45
morbid obesity 45
metastases 45
hypothyroidism 44
sickle cell disease 43
malabsorption 42
SCD 42
anemia 41
prediabetes 41
Alzheimer's disease 41
primary sclerosing cholangitis 40
choline deficiency 40
type 1 diabetes 39
chronic persistent hepatitis 39
lipid disorder 39
myopathy 39
thrombocytopenia 38
eclampsia 37
Reye's syndrome 37
coagulopathy 37
Acute fatty liver of pregnancy 37
cholangitis 36
disseminated intravascular coagulation 36
proteinuria 36
AIDS 35
acute pancreatitis 34
renal failure 33
MRS 33
Evans 32
colorectal cancer 31
heart disease 31
Cirrhosis 31
Wilson's disease 31
sleep apnea 31
myocardial infarction 31
hypobetalipoproteinemia 29
asthma 29
systemic lupus erythematosus 28
celiac disease 28
neuropathy 27
infectious diseases 27
hyperhomocysteinemia 27
Syndrome 26
HCC 26
psoriasis 26
Crohn's disease 26
pruritus 26
hemangioma 25
ABL 25
rheumatoid arthritis 25
AIN 25
coma 24
atherosclerotic cardiovascular disease 24
myocardial ischemia 24
lipoatrophy 24
adenocarcinoma 24
liver metastases 24
Best 24
LDLR 24
Brown 22
vascular disease 22
vitamin D deficiency 22
hyperandrogenism 21
acanthosis nigricans 21
Adenovirus 21
acute alcoholic hepatitis 21
cystic fibrosis 20
retinopathy 20
Chronic hepatitis C 20
pancreatic cancer 20
gout 20
gastroesophageal reflux disease 20
chronic pancreatitis 19
adenoma 19
more...
Symptom
overweight 290
hepatomegaly 176
starvation 68
vomiting 65
diarrhea 54
abdominal pain 49
fatigue 41
nausea 39
hyperemesis gravidarum 35
splenomegaly 32
anesthesia 28
seizures 25
pain 25
anorexia 22
weakness 18
Ill 14
polyuria 14
polydipsia 13
cachexia 11
hepatosplenomegaly 10
hypoproteinemia 10
lethargy 10
collapse 9
constipation 9
nausea and vomiting 9
epigastric pain 8
respiratory distress 8
ketonuria 8
hypotonia 7
headache 7
hypothermia 7
dyspnea 6
ataxia 6
discomfort 6
discomfort 6
exhaustion 5
arthralgia 4
right upper quadrant pain 4
asthenia 4
thinning 4
erythema 4
cerebellar ataxia 4
angina 4
sleepiness 4
acute stress 3
emaciation 3
memory loss 3
stigma 3
Cushingoid 3
Cushingoid 3
myalgia 3
hunger 3
hypercapnia 3
abdominal discomfort 3
bloating 3
Decreased activity 3
hyperemesis 2
HSA 2
Stiffness 2
syncope 2
tremor 2
Spots 2
acidity 2
Wind 2
analgesia 2
prostration 2
oliguria 2
acute abdomen 2
paresis 2
exertional dyspnea 2
menopausal symptoms 2
chronic constipation 2
clubbing 2
corpulence 1
intestinal bleeding 1
bitter taste 1
knee pain 1
abdominal fullness 1
night sweats 1
Skin symptoms 1
hypersomnia 1
abnormal gait 1
fever of unknown origin 1
insomnia 1
flushing 1
POA 1
BHS 1
vertigo 1
heartburn 1
Postoperative pain 1
breath holding 1
intestinal angina 1
abdominal cramps 1
chills 1
swollen penis 1
Appetite suppression 1
functional recovery 1
hot flushes 1
agitation 1
snoring 1
intestinal pain 1
apathy 1
decreased appetite 1
epigastric distress 1
ophthalmoplegia 1
pelvic pain 1
No adverse effect 1
low back pain 1
breast hyperplasia 1
muscle cramps 1
tonic-clonic seizure 1
cough 1
chronic cough 1
productive cough 1
dizziness 1
Drug
vitamin E 112
Ethanol 107
ROS 71
Fructose 60
NADH 54
lysine 54
Kenyan 42
Glucagon 31
Cardiovasc 29
ascorbate 22
niacin 22
ROC 20
Bifidobacterium 20
Monit 19
Vitamin E 18
Ezetimibe 17
Dermatol 17
Portal 16
caffeine 16
EPA 14
Rosiglitazone 13
Liraglutide 13
CAM 13
ALA 13
Exenatide 11
Growth hormone 11
Albumin 11
Leaf 10
Growth hormone 10
Glutathione 10
CCL 9
PCB 8
citric acid 8
IFN-gamma 7
Vitamin A 7
Glycyrrhiza 7
CSF 7
EE2 6
Bezafibrate 6
Fluorescein 6
MAP 6
IL-2 6
lactose 6
Isoniazid 5
Estrogens 5
TAK 5
Alanine 5
DMI 5
ADM 5
Rimonabant 5
Sorafenib 5
Tacrolimus 4
Parkin 4
Ginseng 4
Histamine 4
Activin 4
Propofol 4
Creosote 4
Parkin 4
p75 4
Orlistat 4
AZT 3
CDX 3
DHT 3
Heme 3
Olmesartan 3
Retinoic acid 3
DHT 3
Glycerol 3
Red ginseng 3
Metreleptin 3
Bortezomib 3
Gd-BOPTA 3
AZT 3
Rutin 3
Clofibrate 3
Simvastatin 3
linolenate 3
Myricetin 3
Oxaliplatin 3
Indomethacin 3
TAC 3
CDX 3
Dial 3
Irinotecan 2
RFP 2
Lipitor 2
ENT 2
PMPA 2
Asn 2
Colestimide 2
Citrus unshiu peel 2
Wine 2
pyridoxal phosphate 2
Malotilate 2
Diurnal 2
NVP 2
Triclosan 2
Serum albumin 2
Angiotensin II 2
ZnO 2
ETS 2
nitroglycerin 2
Lipitor 2
Cilostazol 2
Riboflavin 2
Captopril 2
Ginger 2
Schisandra fruit 2
Tenofovir 2
Olive oil 2
Lipitor 2
Pravastatin 2
OTC 2
Fraction 2
Gel 2
Paraffin 2
IL-1ra 2
Aloe 2
Award 2
Vitamin B12 2
ampicillin 2
OTC 2
Ringer's solution 2
FAD 2
Emodin 2
THF 2
Coconut oil 2
Levovist 2
Epigallocatechin 2
Emodin 2
Indocyanine green 1
1-Deoxynojirimycin 1
Platelet concentrate 1
Vitamin B 1
Asthma 1
CTX 1
Proglumide 1
Sevelamer 1
Trifluoperazine 1
Diphenhydramine 1
ABC 1
Apomorphine 1
2-Methoxyestradiol 1
SNL 1
Cidofovir 1
Entecavir 1
Itraconazole 1
Photofrin 1
Coral 1
Antithrombin III 1
CDP 1
Escitalopram 1
Mirtazapine 1
TTC 1
Casodex 1
Valsartan 1
Carbenoxolone 1
NOV 1
Biopolymers 1
more...
Enzyme
alanine aminotransferase 1030
aspartate aminotransferase 640
AMP-activated protein kinase 434
AST 224
mitogen-activated protein kinase 211
superoxide dismutase 207
AMPK 206
AMPK 204
protein kinase 203
acetyl-CoA carboxylase 182
gamma-glutamyl transpeptidase 171
CPT 131
alkaline phosphatase 128
catalase 110
lipoprotein lipase 90
glutathione peroxidase 81
lipase 74
ERK 71
luciferase 67
CPT 56
CPT 56
caspase-3 54
phosphoenolpyruvate carboxykinase 52
diacylglycerol acyltransferase 50
phosphoenolpyruvate carboxykinase 43
lactate dehydrogenase 43
acyl-CoA oxidase 43
phosphoenolpyruvate carboxykinase 43
reverse transcriptase 39
focal adhesion kinase 39
hormone-sensitive lipase 39
protein kinase C 38
CYP7A1 37
glucose-6-phosphatase 37
ATPase 35
acyl-CoA dehydrogenase 33
complex I 32
cholinesterase 30
NADPH oxidase 30
NADPH oxidase 30
alcohol dehydrogenase 29
glucokinase 28
proteasome 27
peroxidase 27
aldehyde dehydrogenase 27
acetylcholinesterase 26
glutamate dehydrogenase 26
glutamate dehydrogenase 26
glutamate dehydrogenase 26
phosphatidylinositol 3-kinase 25
renin 25
glutathione S-transferase 24
glucose-6-phosphate dehydrogenase 23
creatine kinase 22
ACS 21
aldehyde dehydrogenase 21
acyl-CoA synthetase 21
pyruvate carboxylase 21
pyruvate kinase 19
glutathione reductase 19
aldehyde dehydrogenase 19
GSK 19
CYP3A4 19
phospholipase A2 19
3-hydroxyacyl-CoA dehydrogenase 19
aldehyde dehydrogenase 19
aldehyde dehydrogenase 19
LPL 18
collagenase 18
MEK 18
ceruloplasmin 17
caspase-1 17
phosphatidylethanolamine N-methyltransferase 16
cholesterol acyltransferase 16
citrate synthase 16
ACE 15
acyl-CoA dehydrogenase 15
AMP-activated kinase 15
NO synthase 15
phosphoinositide 3-kinase 14
succinate dehydrogenase 14
IKK 14
phosphodiesterase 14
lecithin:cholesterol acyltransferase 14
calcineurin 14
3-hydroxyacyl-CoA dehydrogenase 13
RNA polymerase 13
heme oxygenase 13
soluble epoxide hydrolase 13
thrombin 12
fructokinase 12
xanthine oxidase 12
isocitrate dehydrogenase 11
paraoxonase 11
3-hydroxy-3-methylglutaryl-CoA reductase 11
acyl-CoA synthetase 11
paraoxonase 11
UDP-glucuronosyltransferase 10
glycerol kinase 10
pyruvate dehydrogenase 10
HMG-CoA synthase 10
cystathionine beta-synthase 10
arginase 10
PARP 9
ketohexokinase 9
fatty-acid synthase 9
NQO1 9
caspase-9 9
demethylase 9
glycerol-3-phosphate dehydrogenase 9
hexokinase 9
glutamine synthetase 9
cytochrome oxidase 9
aldose reductase 9
ECH 9
acid phosphatase 9
isocitrate dehydrogenase 8
PDK1 8
malate dehydrogenase 8
type III procollagen 8
thromboplastin 8
ATP synthase 8
phosphatidate phosphatase 8
BAT 7
acyl-CoA thioesterase 7
glycerol-3-phosphate dehydrogenase 7
carboxylesterase 7
aldolase 7
cathepsin B 7
transpeptidase 7
methylenetetrahydrofolate reductase 7
glycerophosphate acyltransferase 7
methylenetetrahydrofolate reductase 7
ornithine transcarbamylase 7
fatty acid elongase 7
trypsin 7
betaine-homocysteine methyltransferase 7
nicotinamide phosphoribosyltransferase 6
TSA 6
CPR 6
sorbitol dehydrogenase 6
prolyl hydroxylase 6
DNA polymerase 6
gamma-glutamylcysteine synthetase 6
lipoxygenase 6
beta-glucuronidase 6
peroxiredoxin 5
pyruvate dehydrogenase 5
cdc2 5
fatty acid desaturase 5
pyruvate dehydrogenase 5
cathepsin D 5
phospholipase D 5
AOR 5
CAD 5
diaphorase 5
caspase-2 5
argininosuccinate synthetase 5
11beta-hydroxysteroid dehydrogenase 5
transcriptase 5
more...
Compound
glucose 2380
Clin 972
Dec 834
ethanol 698
oxygen 479
water 431
DNA 402
methionine 369
Insulin 314
TNF 280
iron 181
palmitic acid 177
ATP 175
CoA 172
palmitic acid 158
GSH 150
GSH 150
phosphate 149
glycerol 135
calcium 126
sodium 121
Oil Red O 110
Oil Red O 102
NAD 101
alanine 99
NAD 80
acetate 79
betaine 76
galactose 73
AMP 68
homocysteine 68
vitamin D 64
nitric oxide 63
adenosylmethionine 63
Fructose 61
Cholesterol 60
lysine 59
serine 59
aldehyde 59
nitrogen 59
tyrosine 58
cysteine 57
CPT 56
nicotinamide 56
urea 56
CPT 56
arginine 55
NADH 54
glutamate 53
CCl4 53
salt 52
FFA 52
acetaldehyde 47
MDA 47
creatinine 46
silver 46
zinc 44
His 43
cAMP 43
leucine 43
copper 42
PMA 42
retinol 40
hydrogen 40
tryptophan 38
tryptophan 38
acetyl-CoA 38
Metformin 37
Metformin 37
tryptophan 35
ammonia 35
threonine 35
Choline 35
GPT 35
tryptophan 35
CO2 34
Resveratrol 32
Glucagon 31
Hematoxylin 31
NADPH 30
NADPH 30
Cardiol 29
alcohol dehydrogenase 29
ALP 28
DHA 28
L-carnitine 28
ADP 28
GSSG 27
Pac 27
Pioglitazone 27
N-acetylcysteine 27
sulfate 27
ADP 26
malonyl-CoA 26
S-adenosylhomocysteine 26
ADP 26
glutamine 26
DHA 24
DHA 24
NADP 23
Curcumin 23
Vitamin E 22
selenium 22
Ile 21
ACS 20
ACS 20
aldehyde 20
Tamoxifen 19
Tamoxifen 19
Oleic acid 19
Sodium 19
adenylate 19
palmitoyl-CoA 18
pentose 18
CAT 18
Thyroid 18
isoleucine 17
TOF 17
Conjugated linoleic acid 17
pentose 17
CAT 17
pentose 17
phosphorus 17
CAT 17
MTT 17
pentose 17
Melatonin 16
isoleucine 16
hyaluronic acid 16
GTP 16
retinoic acid 16
caffeine 16
stearic acid 15
Methionine 15
DPP 15
Estrogen 15
valine 15
TCA 15
Gly 15
Estrogen 15
Phe 15
nicotinic acid 15
methanol 14
Vitamin D 14
uridine 14
pyrimidine 14
8-OHdG 14
potassium 14
manganese 14
pyrimidine 14
aldosterone 14
H2O2 14
EPA 14
Acyl-CoA 13
Triton 13
TSH 13
acetone 13
stearic acid 13
stearic acid 13
Ursodeoxycholic acid 13
more...