Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0015695 (fatty liver)
 13,941 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Rabbits have been epicutaneously exposed to pure hexachlorobutadiene (0.25; 0.50; 0.75 and 1.00 ml/kg) during 8 hrs. This solvent was completely absorbed; some animals died within 24 hrs and others a few days later. The LD50 is 0.72 ml/kg (Bliss' method). Hexachlorobutadiene induced in situ cutaneous necrosis and its absorption induced systemic damage (fatty liver degeneration and epithelial necrotizing nephritis). These lesions are reversible. The present results confirm the toxicological profile of this solvent, previously established by the intraperitoneal and oral routes: hexachlorobutadiene is the most nephrotoxic aliphatic chlorinated hydrocarbon.
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PMID:Percutaneous toxicity of hexachlorobutadiene. 72