Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0015695 (fatty liver)
 13,941 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Four groups of 6 rabbits were subjected to the following diets for 25 weeks: I (controls), II (water with 9.66 mumol/l of lead), III (atherogenic) and IV (atherogenic + 9.66 mumol/l of lead). Lead, magnesium, calcium, zinc and cadmium were then analyzed in 20 dry tissues. At the level of the arteries, veins and skin a tendency was observed toward increased lead concentration in rabbits of groups II and IV, elevated calcium levels in groups III and IV (a tenfold increase of calcium in the aortas), and a higher concentration of cadmium in animals of group II. There was a significant reduction in lead and magnesium concentrations in the liver of animals in groups III and IV because of fibrosis and overabundance of fatty liver cells. The lead level in the liver of animals in group II had slightly increased. Lead concentrations were higher in the kidneys and spleen in groups II and IV. Cadmium levels were significantly lower in the liver, kidneys, adrenal glands and spleen of animals in groups III and IV, whereas in group II they were particularly increased in the liver and kidneys. Very little significant interaction between the two diets was noted. Rabbits in groups III and IV showed notable histopathological alterations in aorta, carotid and femoral arteries, left ventricle and liver. Extrapolation from rabbit to man would be inadvisable.
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PMID:Concentrations of lead, magnesium, calcium, zinc and cadmium in twenty rabbit tissues after exposure to low lead doses and atherogenic diet. 665 Dec 30

Lead has several adverse effects on the body due to one of the environmental pollutants. We aimed to determine the effects of naringenin on the oxidative stress and the hepatic damage against lead acetate treatment in the liver of male rats. Naringenin was administered by orogastric gavage (50 mg/kg) and lead acetate was given as daily 500 parts per million in drinking water for 4 weeks. Lead and antioxidant activities were measured, and histopathological evaluation was performed in the liver. Lead concentrations, malondialdehyde, and antioxidant activity were restored by the naringenin. The grade of necrosis, hydropic degeneration, and hepatic cord disorganization was decreased by the naringenin. However, there were no differences in the degree of sinusoidal congestion, hepatic steatosis, and capsular fibrosis between lead acetate and naringenin + lead acetate groups. We can suggest that naringenin has antioxidant and chelating effects in the liver. Nevertheless, this effect is not enough against the lead acetate induced hepatic injury.
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PMID:Effects of Naringenin on Oxidative Stress and Histopathological Changes in the Liver of Lead Acetate Administered Rats. 2692 48