Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0015695 (
fatty liver
)
13,941
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Methylsulfonylmethane
(
MSM
), an organosulfur compound, has been used as a dietary supplement that can improve various metabolic diseases. However, the effect of
MSM
on obesity-linked metabolic disorders remains unclear. The goal of the current study is to determine whether
MSM
has beneficial effects on glucose and lipid homeostasis in obesity-associated pathophysiologic states. High-fat diet-induced obese (DIO) and genetically obese diabetic db/db mice treated with
MSM
(1%-5% v/v, by drinking water) were studied. Metabolic parameters involved in glucose and lipid metabolism were determined. Treatment of DIO mice with
MSM
leads to a significant decrease in blood glucose levels. DIO mice treated with
MSM
are hypersensitive to insulin, as evidenced by decreased serum insulin and an increase in the area above the curve during an ITT. Concurrently,
MSM
reduces hepatic triglyceride and cholesterol contents in DIO mice. These effects are accompanied by reductions in gene expression of key molecules involved in lipogenesis and inflammation. FACS analysis reveals that
MSM
markedly increases the frequency of B cells and decreases the frequency of myeloid cells in peripheral blood and in bone marrow. Moreover, overnutrition-induced changes of femur microarchitecture are restored by
MSM
. In db/db mice, a marked impairment in glucose and lipid metabolic profiles is notably ameliorated when
MSM
is supplemented. These data suggest that
MSM
has beneficial effects on multiple metabolic dysfunctions, including hyperglycemia, hyperinsulinemia, insulin resistance, and inflammation. Thus,
MSM
could be the therapeutic option for the treatment of obesity-related metabolic disorders such as type 2 diabetes and
fatty liver
diseases.
...
PMID:Methylsulfonylmethane (MSM), an organosulfur compound, is effective against obesity-induced metabolic disorders in mice. 2762 Nov 86
