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Query: UMLS:C0015695 (fatty liver)
 13,941 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A survey of the incidence and severity of post-parturient fatty liver in high yielding dairy cows was carried out on 151 cows and 46 heifers from four Friesian herds and one Guernsey herd. In Friesian and Guernsey cows from the second lactation onwards fat occupied a significant proportion (15 to 32 per cent) of the hepatic parenchyma at one week after calving but decreased to low values at eight weeks after calving. Fatty liver was insignificant in heifers of either breed. When the fatty liver was classified according to the amount of fat at one week after calving, 66 per cent of Friesian cows and 33 per cent of Guernsey cows had a moderate or severe fatty liver. The severity of the fatty liver was related to the loss of condition score after calving but not the condition score at calving.
Vet Rec 1980 Sep 20
PMID:Incidence and severity of fatty liver in dairy cows. 721 Apr 22

Spontaneously hypertensive rats (SHR) were autopsied at timed intervals from weaning to 28 months. Blood pressure reached 180 to 240 mm Hg after 4 months and was maintained. After 20 months, male SHR began to die of myocardial infarction. A survey was made of the histopathologic changes associated with increasing blood pressure and age. Histopathologic changes appeared in males when they became 8 months old; degenerative changes did not appear in female SHR until 12 to 15 months. Degenerative changes consisted of pituitary basophilia, fatty liver, islet hyperplasia and beta cell degranulation which preceded and became exacerbated with worsening hypertension. Intimal fibrino hyalin lesions of the gonads, polyarteritis nodosa, myocardial infarction, and cerebral edema were more severe in males vs females. Female SHR live significantly longer than males (e.g., 28 to 34 months). Hypertension and longevity may be under separate genetic control in SHR.
J Gerontol 1981 Sep
PMID:Histopathologic changes in aging male vs female spontaneously hypertensive rats. 726 33

In a study of 195 patients derived from five centres in northern Britain and with histologically confirmed alcoholic liver disease we have found an increased prevalence of serological markers of hepatitis B. This increased prevalence was found in each of the five centres; the overall frequency ranged from 11% sero-positivity in fatty liver, 12% in alcoholic hepatitis and 27% in cirrhosis.
J Clin Pathol 1981 Sep
PMID:Serological markers of hepatitis B in patients with alcoholic liver disease: a multi-centre survey. 727 16

The serum lipid levels were repeatedly controlled in 25 patients with various skin diseases treated orally with retinoid Ro 10-9359 in different doses. In 19 cases serum lipid values before onset of treatment were taken. 6 additional patients were controlled after long-term intake of the drug over 6-8 months. Pathological elevations of triglycerides were seen in 5 patients, in 4 of them 2-12 weeks after onset of oral treatment. All patients with elevated values had additional risk factors: Manifest or asymptomatic diabetes, alcoholic abuse with fatty liver, adipositas, and/or preexisting disorders of lipid metabolism. The observed changes seemed dose-dependent. The values were lowered or returned to normal after dose reduction or after discontinuation of treatment (one case). The cholesterin levels also showed some elevated values during the time of observation, however, there was no clear relation to the administration of the drug and the daily dose. The changes were also seen preferably in patients with risk factors. Controls of serum lipid levels seem, therefore, indicated before and under administration of oral retinoid. In patients with the additional risk factors mentioned above strict indication for oral retinoid therapy is needed and lower doses should be rather administered.
Z Hautkr 1981 Sep 15
PMID:[Serum triglycerides and cholesterin in patients with skin diseases during oral treatment with aromatic retinoid (author's transl)]. 729 3

The main enzymes involved in orotic acid metabolism, orotate phosphoribosyltransferase and orotidine 5'-phosphate decarboxylase, are associated as a multienzyme complex (complex U) which is present in the liver of most vertebrate species. Orotic-acid-enriched diets produce increased pyrimidine synthesis which competes with purine synthesis for 5-phosphoribosyl diphosphate, resulting in decreased adenylate levels in liver cells. Inhibition of secretion of very low density lipoproteins and hepatic steatosis is then observed. In contrast, lipoproteins secretion by the intestine is not impaired and fat does not accumulate in enterocytes. The aim of this work was to investigate whether orotate is differently metabolized in gut and in liver thus explaining the lack of effect on the intestinal lipoproteins secretion. Complex U was found in appreciable amounts in rat, mouse and rabbit livers; the intestinal mucosa of the two last species contains a much lower level of multienzyme complex whereas in rat intestine its activity cannot be detected. Indeed, radioactive aspartate and orotate were not incorporated into intestinal cells RNA. The absence of orotate metabolisation by lack of orotate phosphoribosyltransferase and orotidine 5'-phosphate decarboxylase activity in rat intestine would explain why this organ, in contrast to the liver, is protected against disturbances of nucleotide metabolism and lipoproteins secretion induced by orotic-acid-supplemented diets.
Eur J Biochem 1981 Sep 01
PMID:Metabolism of orotic acid: lack of orotate phosphoribosyltransferase in rat intestinal mucosa. 729 64

A high energy maize diet produced a higher incidence of fatty liver-haemorrhagic syndrome than a low energy barley diet when the diets were fed during the summer. The triglyceride content of the liver increased with the liver haemorrhage score and in hens with the highest scores there was evidence of hepatic hyperplasia. They also had high activities of aspartate transaminase and cholinesterase in the plasma and a low activity of sorbitol dehydrogenase. There was no increase in plasma endotoxin levels as the syndrome developed or any significant variation in these levels with the haemorrhage score, the triglyceride content of the liver or plasma enzyme activities. It was concluded that the steatosis does not impair the ability of the liver to inactivate endotoxins of enteric bacteria and that these toxins are not involved in the pathogenesis of the syndrome.
Res Vet Sci 1981 Sep
PMID:Bacterial endotoxins and the pathogenesis of fatty liver--haemorrhagic syndrome in the laying hen. 732 74

In a prospective study serum and bile cholesterol concentrations were examined in 233 patients with gallstones. The objective of the study was the selection of patients in which conservative dissolution of gallstones might be successful. The average concentration of cholesterol in serum was 227,46 +/- 41,64 mg/100 ml, in gallbladder bile 8,83 +/- 5,66 mg/100 ml. The cholesterol contents of gallstones was 73,47 +/- 19,47 per cent. Statistical relations were found neither between the cholesterol concentrations in serum and bile nor between the cholesterol contents of gallstones and the cholesterol concentrations in serum and bile. The postoperative cholesterol concentration in serum was remarkably diminished as compared with preoperative values in all patients. A statistically significant decrease of serum cholesterol was seen in patients with histologically proven fatty liver disease. Measuring the cholesterol concentration in serum is no appropriate way for the selection of patients with gallstones for a litholytic treatment. It should be evaluated whether a concomitant fatty liver disease is an indication for a therapeutic trial with chenodesoxycholic acid.
Fortschr Med 1980 Sep 04
PMID:[Cholesterol in the blood and bile]. 746 29

We compared the weights of the brain, heart, spleen, lungs, liver, and kidneys, uncorrected and corrected for body surface area (BSA) and body mass index (BMI), of 50 alcoholics with 50 forensic controls matched for sex, age, and body weight. With the exception of combined renal weight corrected for BSA and BMI, no significant differences were found in organ weights between the two groups. Glomerular diameter corrected for BSA was significantly greater in alcoholics than controls. It appears that nephromegaly and glomerulomegaly are both population markers for alcoholism. In alcoholics, there was no correlation between the microscopic degree of steatosis and glomerulomegaly. In controls, renal glomerular diameter was greater with increasing severity of hepatic steatosis, probably as a reflection of obesity.
Am J Forensic Med Pathol 1995 Sep
PMID:Organomegaly in chronic alcoholics. 749 69

Attenuation differences bordered by straight lines within the liver (the straight border sign) are sometimes seen at computed tomography (CT). This phenomenon, which was demonstrated with unenhanced CT over a dozen years ago, does not represent a hepatic mass and is often associated with vascular compromise. Major causes of the straight border sign include fatty liver, confluent fibrosis, radiation hepatitis, and vascular abnormalities such as tumor thrombus, thromboembolus, compression, and arterioportal shunt. The frequency of this finding increases when intense contrast enhancement is used, especially when contrast material is administered via the superior mesenteric artery (CT during arterial portography) or hepatic artery (CT arteriography). The use of spiral CT is apparently increasing the chances of encountering this sign in daily practice. To correctly interpret the straight border sign, one should consider the distribution (anatomic vs nonanatomic), the attenuation (low vs high), and the use and technique of contrast enhancement.
Radiographics 1995 Sep
PMID:Straight border sign of the liver: spectrum of CT appearances and causes. 750 52

The prevalence of fatty liver in children is unknown and its relationship to obesity is poorly defined. The present study of 810 northern Japanese children (4-12 years old) determined the prevalence of fatty liver in the pediatric population and its relationship to obesity. Diagnosis of fatty liver was based on established real-time ultrasonographic criteria. The overall prevalence of fatty liver was 2.6% and was higher for boys (3.4%) than for girls (1.8%), although not statistically significant (P = 0.15). Fatty liver was found in children as young as 6 years of age. There was no significant association between the prevalence of fatty liver and height (physical growth). There was a strong positive correlation between fatty liver prevalence and established obesity indices: Rohrer's Index--chi 2 linear trend = 59.2, P < 0.0001; body mass index--chi 2 linear trend = 91.6, P < 0.0001; and age-gender-adjusted Japanese standard index of weight for height--chi 2 linear trend = 93.2, P < 0.0001. However, direct measurement of abdominal subcutaneous fat thickness by ultrasonography was the best predictor of fatty liver: chi 2 linear trend = 159, P < 0.0001. These results indicate that fatty liver may develop very early in life, and there is a direct relationship between degree of obesity and fatty liver in children.
Dig Dis Sci 1995 Sep
PMID:Prevalence of fatty liver in Japanese children and relationship to obesity. An epidemiological ultrasonographic survey. 755 56


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