Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0015695 (
fatty liver
)
13,941
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Mitochondrial redox imbalance and high Ca
2+
uptake induce the opening of the permeability transition pore (PTP) that leads to disruption of energy-linked mitochondrial functions and triggers cell death in many disease states. In this review, we discuss the major results from our studies investigating the consequences of NAD(P)-
transhydrogenase
(NNT) deficiency, and of statins treatment for mitochondrial functions and susceptibility to Ca
2+
-induced PTP. We highlight the aggravation of high fat diet-induced
fatty liver
disease in the context of NNT deficiency and the role of antioxidants in the prevention of statins toxicity to mitochondria.
...
PMID:Facilitation of Ca
2+
-induced opening of the mitochondrial permeability transition pore either by nicotinamide nucleotide transhydrogenase deficiency or statins treatment. 2942 67
