Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0015695 (fatty liver)
 13,941 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Three groups of freshly calved dairy cows suffering from fatty liver syndrome of different stages were examined for serum cholic acid (SCA) levels to assess the value of SCA-determination as a diagnostic approach to fatty liver syndrome. A. Comparison of the SCS levels between cows with and without ketonuria: Cows with ketonuria (n = 13) and with elevated plasma ASAT activity, indicating a moderate liver damage, showed a rise of their mean SCA level to 35.3 (+/- 14.9) mumol/l. Freshly calved cows without ketonuria (n = 10) had at the same time a mean SCA level of 17.9 (+/- 6.4) mumol/l, falling practically into the physiological range. The SCA level increased above the physiological range in 10 of the 13 cases with ketonuria, in seven of them even more than twice. B. Interrelationship between SCA level and hepatic lipid content: Increase in hepatic total lipid (TL) was always associated with SCA-elevation. The mean SCA level was 55 (+/- 22.0) mumol/l in cases of severe fatty liver (TL = 200-280 g/kg), and 39.5 (+/- 6.0) mumol/l in the moderate form (TL = 180-200 g/kg) of the syndrome. C. Peripartal SCA levels of cows with fatty liver: Clinically healthy cows (n = 6) with ketonuria and an elevation of serum ASAT and FFA concentrations had a mean SCA level of 35-45 mumol/l. One cow of this group, which developed acute fatty liver syndrome and died within the period of study, showed an extreme SCA level of 100 mumol/l in it's terminal stage.(ABSTRACT TRUNCATED AT 250 WORDS)
 ...
PMID:[Cholic acid levels in the serum of dairy cows with metabolically-caused liver diseases]. 204 69

In this prospective study the impact of fatty liver and an impaired liver function on the treatment outcome of displacement of the abomasum (DA) was investigated. In a yearlong period, all cows suffering from DA submitted to the clinic were included in this study. All cows were clinically examined before surgery and a serum sample was taken to measure the following parameters: ASAT, bilirubin, urea. Liver biopsy was performed in all cows. Liver fat content was measured gravimetrically and concentrations of triglycerides were measured using a commercial test kit. Reposition of DA was done using the method by Dirksen. A total of 365 cows with DA entered the study, 326 (89.3%) suffered from LDA and 39 (10.7%) from RDA. RDA-cows had significantly (p = 0.002) more days in milk than LDA-cows. RDA-cows had significantly (p < 0.001) higher urea concentrations than LDA-cows. Bilirubin concentrations (p = 0.008) and liver fat content, triglyceride concentrations and the ratio of triglycerides to fat (TRI/FAT) (p < 0.001) were significantly higher in LDA-cows. The majority of LDA-cows showed at least a mild fatty liver. Comparing the cows with successful and failed treatment showed that ASAT-activity (p = 0.021), bilirubin concentration (p = 0.001), triglyceride concentration in liver and TRI/FAT (all p < 0.001) were significantly higher in the unsuccessfully treated cows. In RDA cows, significant differences between successfully and unsuccessfully treated cows were only seen in urea concentration (p = 0.004). ROC-analysis was performed to determine whether any parameter is suitable for a prediction of treatment outcome. In RDA-cows no threshold value was traceable for urea concentration. In LDA cows, TRI/FAT showed the best curve progression. The threshold value of 53.5 % had a sensitivity of 0.720 and a specificity of 0.700. LDA-cows exceeding this threshold had a 2.4 higher risk of an unsuccessful treatment. Due to the good overall treatment success (92.3 %) the positive predictive value for an unsuccessful or ineffective treatment was 0.368 only. The results of our study clearly show that impaired liver function plays an important role in the outcome of treatment of LDA but not RDA. In spite of this no laboratory parameter provides sufficient power to make a predictive statement of treatment outcome.
 ...
PMID:The use biochemical and hepatic parameters to predict treatment outcome of dairy cows suffering from displacement of the abomasum. 1764 23