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Query: UMLS:C0015695 (fatty liver)
 13,941 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Varying degrees of biotin deficiency were induced by adding freeze-dried, raw egg white to the diet of broiler chicks. Aspects of liver metabolism were studied with reference to fatty liver and kidney syndrome. Mortality was low with 11.8 g egg white/kg diet, or less, but with 17.7 g/kg or more, mortality was very high. High mortality was observed with less than 0.33 microgram biotin/g liver. Associated with low concentrations of liver biotin were substantial increases in liver weight and lipid content in starved birds. The increased liver lipid content was not observed in birds fed ad libitum. The increased liver lipid content in biotin-deficient, starved birds was not reflected in the specific activities of hepatic lipogenic enzymes or hepatic lipogenesis in vivo measured by the incorporation of tritium from 3H-labelled water into liver lipid. Biotin deficiency affected the specific activities of the biotin-requiring enzymes, pyruvate carboxylase and acetyl CoA carboxylase, differently; the latter was unaffected whereas the former decreased concomitantly with liver biotin concentration.
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PMID:Biotin deficiency and liver metabolism in relation to fatty liver and kidney syndrome. 67 52

Biotin deficiency can be induced readily in monogastric animals and is accompanied by characteristic abnormalities. These include dermal lesions involving hyper- and parakeratosis and, in fur-bearing animals, alopecia and achromatricia. Biochemical changes include depressions in the activities of biotin-dependent enzymes and the metabolic pathways in which they are involved. However, it has been shown in chickens that the relative changes in the activities of these enzymes and the resultant manifestations of the deficiency can be markedly influenced by the dietary content of other nutrients such as protein or fat. Biochemical criteria are required for the diagnosis of subclinical deficiency and these are best-established for poultry. Blood pyruvate carboxylase activity is a good criterion in young birds. Biotin-responsive disorders have been identified in several species. The etiology of fatty liver and kidney syndrome in chickens is now largely understood and is an interesting example of how a combination of nutritional and environmental factors can result in sudden death in, until then, apparently healthy animals.
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PMID:Assessment of biotin deficiency in animals. 286 81