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Query: UMLS:C0015695 (
fatty liver
)
13,941
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
In this prospective study the impact of
fatty liver
and an impaired liver function on the treatment outcome of displacement of the abomasum (DA) was investigated. In a yearlong period, all cows suffering from DA submitted to the clinic were included in this study. All cows were clinically examined before surgery and a serum sample was taken to measure the following parameters: ASAT, bilirubin, urea. Liver biopsy was performed in all cows. Liver fat content was measured gravimetrically and concentrations of triglycerides were measured using a commercial test kit. Reposition of DA was done using the method by Dirksen. A total of 365 cows with DA entered the study, 326 (89.3%) suffered from
LDA
and 39 (10.7%) from RDA. RDA-cows had significantly (p = 0.002) more days in milk than
LDA
-cows. RDA-cows had significantly (p < 0.001) higher urea concentrations than
LDA
-cows. Bilirubin concentrations (p = 0.008) and liver fat content, triglyceride concentrations and the ratio of triglycerides to fat (TRI/FAT) (p < 0.001) were significantly higher in
LDA
-cows. The majority of
LDA
-cows showed at least a mild
fatty liver
. Comparing the cows with successful and failed treatment showed that ASAT-activity (p = 0.021), bilirubin concentration (p = 0.001), triglyceride concentration in liver and TRI/FAT (all p < 0.001) were significantly higher in the unsuccessfully treated cows. In RDA cows, significant differences between successfully and unsuccessfully treated cows were only seen in urea concentration (p = 0.004). ROC-analysis was performed to determine whether any parameter is suitable for a prediction of treatment outcome. In RDA-cows no threshold value was traceable for urea concentration. In
LDA
cows, TRI/FAT showed the best curve progression. The threshold value of 53.5 % had a sensitivity of 0.720 and a specificity of 0.700.
LDA
-cows exceeding this threshold had a 2.4 higher risk of an unsuccessful treatment. Due to the good overall treatment success (92.3 %) the positive predictive value for an unsuccessful or ineffective treatment was 0.368 only. The results of our study clearly show that impaired liver function plays an important role in the outcome of treatment of
LDA
but not RDA. In spite of this no laboratory parameter provides sufficient power to make a predictive statement of treatment outcome.
...
PMID:The use biochemical and hepatic parameters to predict treatment outcome of dairy cows suffering from displacement of the abomasum. 1764 23
Background:
Displaced abomasum (DA) is a condition of dairy cows that severely impacts animal welfare and causes huge economic losses.
Objective:
To assess the metabolic status of the disease using metabolomics in serum, urine and liver samples aimed at both water soluble and lipid soluble fractions.
Methods:
Fifty Holstein multiparous cows with DA (42 left, 8 right) and 20 clinically healthy Holstein multiparous cows were used. Left DA was associated with concomitant ketosis in 19 animals and right in two. NMR-based metabolomics approach and hematological and biochemical analyses were performed. Statistical analysis was carried out on
1
H-NMR data after they have been normalized using PQN method.
Results:
Contrary to generated PCA score plots the OPLS-supervised method revealed differences between healthy animals and diseased ones based on serum water-soluble samples. While water and lipid soluble metabolites decreased in serum samples, fatty acid fractions and cholesterol were increased in liver samples in DA affected cows. The metabolomic and chemical profiles clearly revealed that cows with DA (especially with
LDA
) were at risk of ketosis and
fatty liver
. Serum hippuric acid concentration was significantly higher in healthy cows in comparison with
LDA
, whereas serum glycine concentration was reported higher for healthy when compared to RDA affected animals.
Conclusion:
A biochemical network and pathway mapping revealed 'valine, leucine and isoleucine biosynthesis' and 'phenylalanine, tyrosine and tryptophan biosynthesis' as the most probable altered metabolic pathway in DA condition. Serum was advocated as the optimal biological matrix for the
1
H-NMR analysis.
...
PMID:Nuclear magnetic resonance (NMR)-based metabolome profile evaluation in dairy cows with and without displaced abomasum. 3185 82
