Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0015695 (
fatty liver
)
13,941
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
NAD
+
is a co-enzyme in redox reactions and a substrate required for activity of various enzyme families, including sirtuins and poly(ADP-ribose) polymerases. Dietary supplementation of NAD
+
precursors nicotinamide mononucleotide (NMN) or nicotinamide riboside (NR) protects against metabolic disease, neurodegenerative disorders and age-related physiological decline in mammals. Here we sought to identify the roles of
nicotinamide riboside kinase 1
(
NRK1
) plays in regulating hepatic NAD
+
biosynthesis and lipid metabolism. Using adenovirus mediated gene transduction to overexpress or knockdown
NRK1
in mouse liver, we have demonstrated that
NRK1
is critical for maintaining hepatic NAD
+
levels and triglyceride content. We have further shown that the hepatic expression of Nmrk1 mRNA is significantly decreased either in mice treated with high-fat diet or in aged mice. However, adenoviral delivery of
NRK1
in these diet- and age-induced mice elevates hepatic NAD
+
levels, reduces
hepatic steatosis
, and improves glucose tolerance and insulin sensitivity. Our results provide important insights in targeting
NRK1
for treating
hepatic steatosis
.
...
PMID:Overexpression of NRK1 ameliorates diet- and age-induced hepatic steatosis and insulin resistance. 2967 70
