Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0015674 (chronic fatigue syndrome)
 2,978 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
TRPM3 protein 11.8
ATP5J2 11.1
SLC25A40 10.8
PCPE 9.4
Zinc finger protein 423 9.1
glucose transporter 10 9.1
FLOT1 9.0
P2RX4 9.0
HLA-DRB1*1301 8.9
CD69 molecule 8.9
WASF3 8.9
sperm acrosomal protein 8.8
HTR5A 8.7
HTR4 8.7
RNase L 8.6
CHRM1 8.6
SLC2A10 8.5
transcription factor A, mitochondrial 8.5
IMMP2L 8.5
FCN1 8.5
PSMA4 8.5
HTR3A 8.5
GRID2 8.4
HTR3B 8.3
Neurobeachin 8.2
WAVE3 8.1
RNASEL 8.1
COX5B 8.0
APQ 8.0
PKN1 7.9
ATP synthase subunit beta 7.9
5HT1a 7.9
BDCA2 7.9
ADCY3 7.9
MACF1 7.8
arresten 7.8
TOB 7.7
RASSF5 7.7
HTR2B 7.7
IL2RB 7.7
PSMA3 7.7
HLA-DRB1*11 7.7
cystatin F 7.7
RAP1B 7.6
L-glutaminase 7.6
GABPA 7.6
voltage gated potassium channel 7.6
COPE 7.6
DLG2 7.6
IGHV3-23 7.5
TA4 7.5
KIR2DL5 7.5
TRKC 7.5
Fanconi anemia protein 7.5
NB2 7.5
CPZ 7.4
p101 7.4
mpo 7.4
adenosine monophosphate deaminase 7.4
MASP1 7.4
INSIG1 7.4
DAB1 7.3
KIR2DS5 7.3
IL1RAPL1 7.3
PUB 7.3
IDO2 7.2
EBI2 7.2
ribosomal protein P0 7.2
HLA-DQB1*03 7.2
PIK3R3 7.1
IL-17B 7.1
HTR1A 7.0
APOBEC3F 7.0
OB1 7.0
NLRP3 protein 7.0
PRF1 6.9
myoadenylate deaminase 6.9
RELB 6.9
M-ficolin 6.8
AMPD1 6.8
IL-1R2 6.8
lens epithelium-derived growth factor 6.7
delta-6-desaturase 6.6
FSS 6.6
IGFR1 6.6
GCR 6.6
CPT II 6.6
RORA 6.6
aconitate hydratase 6.5
TRPM3 6.5
NR3C2 6.5
CTM 6.5
SKIP 6.4
Hpa1 6.4
HTR2A 6.4
2'-5' oligoadenylate synthetase 6.4
interferon regulatory factor 5 6.4
DBI 6.4
HLA-DRB1*03 6.3
2-5A synthetase 6.3
tetherin 6.3
HLS 6.3
FAN 6.3
maltase-glucoamylase 6.3
LEDGF 6.3
NTRK3 6.3
2',5'-oligoadenylate synthetase 6.2
alpha synuclein 6.2
thyroid hormone responsive 6.2
HTR2C 6.2
KIR3DS1 6.2
HPA 6.2
PYGM 6.1
Eotaxin 6.1
LARGE 6.1
TRIM5alpha 6.1
CNTNAP2 6.1
FMF 6.1
CPT2 6.0
SIRT4 6.0
ubiquitin C 6.0
LN1 6.0
nuclear envelope protein 6.0
X-receptor 6.0
BDCA-2 6.0
NSCL 6.0
B-5 6.0
LCE 5.9
KTS 5.9
adenylate cyclase-coupled 5.9
S31 5.9
B19 5.9
NMU 5.8
SREBF1 5.8
PCK1 5.8
phosphoglycerate kinase 1 5.8
p29 5.8
tryptophan hydroxylase 2 5.7
MERRF 5.7
CCL27 5.7
Transcription factor IIIA 5.7
LIR 5.7
ficolin 5.7
IL-17F 5.7
succinic semialdehyde dehydrogenase 5.7
TRPM4 5.6
mannose binding lectin 5.6
SRL 5.6
EGR2 5.6
TRF1 5.5
transcortin 5.5
NIF 5.5
putative protein kinase 5.4
natural killer cell 5.4
TPH2 5.4
MCS 5.4
ephrin-B1 5.4
hereditary prostate cancer 5.4
trkC 5.4
neutral amino acid transporter 5.4
more...
Disease
chronic fatigue syndrome 13.4
neuromyasthenia 12.0
Idiopathic Hypersomnia 11.8
Stockholm syndrome 11.1
nervous exhaustion 10.8
CCNP 10.8
Gulf War Syndrome 10.5
DYX3 10.4
myofasciitis 10.3
Multiple chemical sensitivity 9.9
Physical deconditioning 9.8
fibromyalgia 9.8
chemical hypersensitivity 9.7
Eosinophilia myalgia syndrome 9.7
Equine Encephalitis 9.6
Irlen syndrome 9.5
sick building syndrome 9.4
Beard 9.3
neurocirculatory asthenia 9.2
Chronic Q fever 9.2
Postural orthostatic tachycardia syndrome 9.1
infectious encephalomyelitis 9.1
roseola infantum 9.0
Porencephaly 8.9
organic affective syndrome 8.8
WT3 8.7
Orthostatic intolerance 8.7
Wegener's granuloma 8.6
unable to remember 8.6
Atypical depression 8.6
Delayed sleep phase syndrome 8.4
somatization disorder 8.3
allergic urticaria 8.1
EBSS 7.8
adjustment reaction 7.8
SFS 7.8
psychological disease 7.6
postpolio syndrome 7.5
Allergic fungal sinusitis 7.5
despondency 7.5
craniofrontonasal syndrome 7.5
hypothalamic disorder 7.3
histrionic personality disorder 7.2
roseola 7.2
disabling disease 7.2
Carnitine deficiency 7.2
Borna disease 7.2
irritable bowel syndrome 7.1
dysautonomia 7.1
idiopathic disorder 7.0
infectious mononucleosis 7.0
autonomic disorder 6.9
interstitial cystitis 6.9
FSS 6.8
compulsive personality 6.8
Familial amyloid polyneuropathy 6.8
pars planitis 6.7
Myofascial pain 6.7
Bornholm 6.7
alcoholic myopathy 6.7
anxiety depression 6.7
emotional upset 6.7
neurotic depression 6.5
Recurrent aphthous stomatitis 6.5
Giardia infections 6.5
catatonic schizophrenia 6.5
kleptomania 6.5
diabetic ulcer 6.5
erythroblastosis fetalis 6.5
psychosomatic disorders 6.5
CTM 6.4
anomie 6.4
psychiatric diagnosis 6.3
regional pain syndrome 6.3
Rust 6.3
Expressed Emotion 6.3
trench fever 6.3
Vasovagal syncope 6.3
Vulvovaginal candidiasis 6.2
tension headache 6.2
sleep disturbances 6.2
HPA 6.2
sleep disorders 6.1
hysteria 6.1
physical disorders 6.1
Sleep disturbance 6.1
psychasthenia 6.1
anxiety state 6.0
EBV infection 6.0
hyperventilation syndrome 5.9
organic disease 5.9
psychological disturbance 5.8
claustrophobia 5.8
Q fever 5.7
hypochondriasis 5.7
PEM 5.7
clinical depression 5.7
Addison's disease 5.7
MERRF 5.7
AIDS/HIV 5.7
restless legs syndrome 5.7
psychogenic disorders 5.7
psychological impairment 5.6
Epstein 5.6
Addison's disease 5.6
Parvovirus B19 infection 5.6
bone neoplasm 5.6
POEMS syndrome 5.6
FRAXA 5.6
fear of cancer 5.5
blunted affect 5.5
narcolepsy 5.5
SAD 5.5
BPS 5.5
hepatic porphyria 5.5
MCS 5.5
MCS 5.4
Lyme arthritis 5.4
HIV encephalopathy 5.4
GRTH 5.4
Sjogren's syndrome 5.4
Brucella abortus 5.3
posttransfusion hepatitis 5.3
immune disorder 5.3
RSI 5.3
dysthymia 5.3
emotional instability 5.3
chronic pain 5.3
Sexual dysfunction 5.3
Lyme disease 5.3
brain dysfunction 5.3
emotional disturbance 5.3
viral meningitis 5.2
Body dysmorphic disorder 5.2
major depressive episode 5.2
memory disorder 5.2
Clostridium difficile infection 5.2
Mastocytosis 5.1
separation anxiety 5.1
orphan disease 5.1
flashbacks 5.1
major depressive disorder 5.1
ACTH deficiency 5.0
herpes 5.0
Candida albicans infection 5.0
leptomeningeal metastases 5.0
presenile dementia 5.0
psychoticism 5.0
TAS 4.9
meningococcemia 4.9
polyneuritis 4.9
multiple sclerosis 4.9
polio 4.9
urticaria pigmentosa 4.9
melancholia 4.9
lactose intolerance 4.9
immune complex disease 4.9
parvovirus 4.9
sudden infant death syndrome 4.9
frozen shoulder 4.9
more...
Symptom
Cancer Fatigue 10.3
febricula 9.5
mental fatigue 9.2
Cutaneous anergy 9.1
generalized pain 8.8
fatigue 7.8
abnormal reflex 7.6
Joint hypermobility 7.4
nerve root irritation 7.4
myalgia 7.3
situational stress 7.0
Vulvodynia 6.9
lightheadedness 6.7
hypersomnia 6.7
Ill 6.6
Visual symptoms 6.6
glossodynia 6.6
polymyalgia 6.5
sore throat 6.5
bladder pain 6.4
body pain 6.3
lassitude 6.2
physical exhaustion 6.0
forgetfulness 6.0
frequent urination 6.0
precordial pain 5.9
hyperacusis 5.9
Chronic pelvic pain 5.8
asthenia 5.6
disturbed balance 5.6
arthralgia 5.5
aphonia 5.4
hyperesthesia 5.3
Decreased activity 5.3
alexithymia 5.2
exhaustion 5.2
Depressive symptoms 5.0
insomnia 4.9
eye pain 4.8
syncope 4.7
Spots 4.6
sleepiness 4.5
orofacial pain 4.5
stomach pain 4.4
memory loss 4.4
photophobia 4.3
despair 4.3
adenitis 4.2
headache 4.2
excessive sweating 4.2
pleuritic chest pain 4.2
night sweats 4.2
Fluctuation 4.1
presyncope 4.1
neck stiffness 4.1
chills 4.1
atypical chest pain 4.1
limb pain 4.0
pelvic pain 4.0
stigma 3.8
chronic back pain 3.8
facial pain 3.8
dizziness 3.7
dysuria 3.7
hypocapnia 3.7
weakness 3.6
neurological disability 3.5
pain 3.5
blurred vision 3.4
joint stiffness 3.3
hot flashes 3.3
Hudson 3.3
catatonia 3.3
rhinorrhea 3.2
lethargy 3.2
decreased appetite 3.2
low back pain 3.1
chronic constipation 3.1
dry eye 3.0
snoring 2.9
acute stress 2.8
menopausal symptoms 2.7
abdominal discomfort 2.6
anorexia 2.6
shortness of breath 2.6
incoordination 2.6
hemiplegia 2.4
chronic cough 2.4
fever of unknown origin 2.4
myoclonus 2.3
chest pain 2.3
erythema 2.3
ataxia 2.2
vertigo 2.2
back pain 2.1
discomfort 2.1
spasm 2.1
paresthesia 2.1
masculinization 2.1
nausea 2.0
shoulder pain 1.9
paresis 1.9
hoarseness 1.9
bone pain 1.8
discomfort 1.7
tinnitus 1.7
ophthalmoplegia 1.7
abdominal pain 1.6
dysarthria 1.5
neck pain 1.4
agitation 1.4
apathy 1.4
dystonia 1.3
dyspnea 1.2
constipation 1.1
hyperoxia 1.0
diarrhea 1.0
cachexia 0.9
hepatomegaly 0.9
cough 0.8
seizures 0.8
flushing 0.7
spasticity 0.7
distraction 0.2
splenomegaly 0.1
vomiting 0.0
overweight -0.3
acidity -0.5
hypothermia -0.7
anesthesia -0.8
tremor -0.8
angina -1.0
analgesia -1.4
collapse -1.4
Drug
CFS 13.4
Alferon N 9.9
CZX 9.8
LMOX 9.4
CEZ 9.2
CMZ 9.2
Naltrexone hydrochloride 9.1
CMX 8.9
AMK 8.8
OFLX 8.5
CXM 7.7
CFX 7.7
CPZ 7.4
Elm 7.4
Jujube 7.2
CET 7.1
CAZ 7.0
Epivir 6.9
Midodrine 6.9
Valganciclovir 6.9
Moclobemide 6.9
Isoprinosine 6.6
CTM 6.5
Modafinil 6.4
CEX 6.3
CTM 6.0
Agomelatine 5.9
CER 5.3
CTT 4.7
Pregabalin 4.6
OMP 4.5
Fraction 4.4
Orphan 4.3
CSF 4.2
PPA 4.2
CFT 4.2
CPM 4.2
Sulpiride 4.2
IPM 3.9
Ganciclovir 3.8
BH4 3.8
TEL 3.8
DBS 3.6
DEX 3.5
CTX 3.5
CTX 3.5
Bifidobacterium 3.4
Acyclovir 3.4
MRC 3.2
AMC 3.2
Horizon 3.1
CCL 3.0
G-CSF 3.0
AZT 3.0
Glycyrrhiza 2.9
AZT 2.8
TAC 2.7
Vitamin E 2.7
Ginseng 2.7
CTX 2.7
NaI 2.6
NaI 2.6
NaI 2.6
NaI 2.6
p75 2.5
Check 2.4
ascorbate 2.4
Portal 2.3
Silica 2.2
Clonidine 2.1
IL-2 2.1
ETS 2.0
Posture 2.0
Alanine 1.9
Rituximab 1.9
IFN-beta 1.8
Retinoic acid 1.7
Asthma 1.5
niacin 1.5
ROC 1.5
Spectrum 1.4
IFN-gamma 1.4
Albumin 1.2
Glutathione 1.0
ROS 0.7
caffeine 0.6
Spectrum 0.4
Biopolymers 0.3
ENT 0.3
Ethanol 0.1
citric acid 0.1
TiO2 -0.1
ZnO -0.4
Gel -0.5
MAP -0.6
ampicillin -0.7
Monit -0.7
vitamin E -0.7
Leaf -1.0
NADH -1.0
lysine -1.5
Dermatol -3.6
Enzyme
serum carnosinase 7.6
pyroglutamate aminopeptidase 6.0
furin 5.9
MCS 5.4
succinic semialdehyde dehydrogenase 5.2
dUTPase 4.7
SCP 4.6
pyruvate dehydrogenase 4.2
pyruvate dehydrogenase 4.2
CCS 4.2
factor C 4.1
GTP cyclohydrolase I 4.0
neutral sphingomyelinase 4.0
CPM 4.0
pyruvate dehydrogenase 4.0
AMP deaminase 4.0
indoleamine 2,3-dioxygenase 3.9
CEP 3.8
CFI 3.8
m-calpain 3.7
FFT 3.6
p100 3.6
neutrophil elastase 3.4
bromelain 3.4
CEP 3.3
myosin ATPase 3.2
transketolase 3.0
TOR 2.9
citrate synthase 2.8
Alternating 2.8
STR 2.7
PRA 2.7
PTA 2.7
aconitase 2.6
tryptophan hydroxylase 2.6
elastase 2.6
glutaminase 2.5
lactase 2.3
chaperonin 2.3
CPT 2.2
sucrase 2.2
reverse transcriptase 2.0
asparaginase 2.0
creatine kinase 2.0
myosin light chain kinase 2.0
thyroid peroxidase 1.8
transcriptase 1.8
ribonuclease 1.7
granzyme B 1.7
ribonuclease 1.7
thymidylate synthase 1.6
nitrate reductase 1.5
nitrate reductase 1.5
nitrate reductase 1.5
nitrate reductase 1.5
nitrate reductase 1.5
adenylate cyclase 1.5
nitrate reductase 1.5
proteinase K 1.4
RNase 1.4
cathepsin B 1.4
cholinesterase 1.3
alpha-glucosidase 1.3
DNA polymerase 1.3
AMP-activated protein kinase 1.3
cytochrome oxidase 1.3
complex I 1.3
RNase 1.3
topoisomerase 1.2
malate dehydrogenase 1.2
glutathione reductase 1.2
invertase 1.1
topoisomerase 1.1
catalase 1.1
deaminase 1.1
monoamine oxidase 1.0
glutathione peroxidase 1.0
phosphorylase 0.9
AMPK 0.8
superoxide dismutase 0.7
prostate-specific antigen 0.6
lysozyme 0.6
NOS 0.6
protein kinase 0.5
DNase 0.5
beta-glucuronidase 0.5
NO synthase 0.4
succinate dehydrogenase 0.4
xanthine oxidase 0.4
plasmin 0.2
acetylcholinesterase 0.2
proteasome 0.2
lactate dehydrogenase 0.1
NADPH oxidase 0.1
NADPH oxidase -0.1
RNA polymerase -0.1
renin -0.2
ERK -0.2
AMPK -0.2
luciferase -0.3
beta-lactamase -0.3
beta-galactosidase -0.5
thrombin -0.6
MEK -0.8
collagenase -0.8
phospholipase C -0.8
endonuclease -0.8
lipase -0.8
phosphodiesterase -0.8
aspartate aminotransferase -1.0
ACS -1.3
mitogen-activated protein kinase -1.6
ATPase -1.6
protein kinase C -2.2
peroxidase -2.6
Compound
R 2010 7.8
Midodrine 7.3
Valacyclovir 7.2
CPZ 7.2
3-Hydroxykynurenine 7.1
Cefsulodin 7.0
Aluminum hydroxide 6.8
Phenylhydrazine 6.7
25-Hydroxyvitamin D 6.6
ONT 6.6
DBI 6.3
5-oxoproline 6.3
KTS 5.9
Poly I 5.8
Mercury, 5.7
Mercury, 5.7
Mercury, 5.7
Mercury, 5.7
Mercury, 5.7
Mercury, 5.7
Mercury, 5.7
5-oxoproline 5.6
PDQ 5.6
Acetyl-L-carnitine 5.6
Carnitine 5.5
DBI 5.5
Soman 5.4
Trazodone 5.4
NFS 5.4
neopterin 5.4
Chlorpromazine 5.2
Bupropion 5.2
coenzyme Q10 5.2
Apocynin 5.1
pyrroline-5-carboxylate 5.1
IDC 5.1
Alprazolam 5.1
Cefazolin 5.0
DHB 4.9
L-carnitine 4.8
3-methylhistidine 4.8
Coenzyme Q10 4.8
Morin 4.6
d-Amphetamine 4.6
MAOA 4.6
Buspirone 4.5
Lindane 4.5
Amantadine 4.4
Amantadine 4.4
OMP 4.4
azelaic acid 4.4
ASN 4.3
Amantadine 4.3
MNU 4.3
ECP 4.3
Epigallocatechin gallate 4.3
ECP 4.3
ECP 4.3
Astaxanthin 4.3
Cortisol 4.3
ECS 4.2
CCS 4.1
Tempol 4.1
Amantadine 4.0
MNU 4.0
PPA 4.0
Phosphatidylserine 4.0
HPT 4.0
PPA 4.0
Benzene 3.9
phosphocreatine 3.9
Interleukin-2 3.9
5-HIAA 3.9
succinic acid 3.8
succinic acid 3.8
succinic acid 3.8
succinic acid 3.8
Nimodipine 3.8
DEP 3.8
myristic acid 3.8
MPC 3.8
TEL 3.8
Vitamin D3 3.7
5-HTP 3.7
HfO2 3.7
DHA 3.7
Chondroitin sulfate 3.7
5-HTP 3.7
Norton 3.7
Vitamin D3 3.6
Tumor Necrosis Factor 3.6
Malondialdehyde 3.6
DBS 3.6
Glyphosate 3.6
BAA 3.6
ACTH 3.5
DRB 3.5
Minocycline 3.5
myristic acid 3.5
DEP 3.4
Imipramine 3.4
Imipramine 3.4
Naltrexone 3.4
Agar 3.4
benzamide 3.4
beta-alanine 3.4
CAA 3.4
Acyclovir 3.4
Xenon 3.4
phthalic acid 3.3
phthalic acid 3.3
phthalic acid 3.3
ANA 3.3
ANA 3.3
DMD 3.2
HCB 3.2
succinic acid 3.2
p-xylene 3.1
Risperidone 3.1
FTA 3.1
PAN 3.1
adenylate 3.1
Glyphosate 3.0
2,3-diphosphoglycerate 3.0
DFS 3.0
Capsaicin 3.0
Lactic acid 3.0
Sphingosine 3.0
TTS 3.0
Phenylephrine 3.0
CES 3.0
Formal 2.9
Lip 2.9
HPP 2.9
Erythromycin 2.9
3TC 2.8
1H-indole 2.8
tryptophan 2.7
AZT 2.7
CAP 2.7
N-acetylaspartate 2.7
CCP 2.7
PLP 2.7
tryptophan 2.7
Tetracycline 2.7
tryptophan 2.7
tryptophan 2.7
isocitrate 2.7
CTX 2.7
folinic acid 2.6
ubiquinol 2.6
EDS 2.6
5-HT 2.6
DSM 2.6
TCA 2.6
Choline 2.5
CCC 2.5
CCC 2.5
CAP 2.5
Abbott 2.5
more...