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Query: UMLS:C0015674 (chronic fatigue syndrome)
 2,978 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The chronic fatigue syndrome is a poorly defined symptoms complex characterized primarily by chronic or recurrent debilitating fatigue and various combinations of other symptoms, including psychological symptoms, sore throat, lymph node pain, headache, myalgia, arthralgias. Psychological disturbances, ranging from mild depression or anxiety to severe behavioral abnormalities, are always present. Chronic fatigue syndrome is the name that more accurately describes this symptom complex of unknown cause. A viral aetiology has long been hypothesized: many viruses are potential candidates, including any of the 23 Coxsackie A or 6 Coxsackie B viruses, herpes viruses, particularly Epstein-Barr virus and varicella. These studies, though interesting, remain unconvincing because of methodological flaws such as a poor case definition and inadequate control groups. This syndrome may represent an infection by a yet unidentified virus. It is more likely due to an abnormal immune response toward different intracellular pathogens. There is no treatment to ameliorate the chronic fatigue syndrome. Epidemiological studies are essential with explicit operational case definition before progress can be made in the management of this distressing disorder.
Recenti Prog Med 1990 Dec
PMID:[The chronic fatigue syndrome. A multifactorial approach and the treatment possibilities]. 207 78

Chronic fatigue syndrome (CFS), including myalgic encephalomyelitis (ME) and postviral syndrome (PVS), is a term used today to describe a condition of incapacity for making and sustaining effort, associated with a wide range of symptoms. None of the reviews of CFS has provided a proper consideration of the effort syndrome caused by chronic habitual hyperventilation. In 100 consecutive patients, whose CFS had been attributed to ME or PVS, the time course of their illness and the respiratory psychophysiological studies were characteristic of chronic habitual hyperventilation in 93. It is suggested that the labels 'CFS', 'ME' or 'PVS' should be withheld until chronic habitual hyperventilation - for which conventional rehabilitation is available - has been definitively excluded.
J R Soc Med 1990 Dec
PMID:Is chronic fatigue syndrome synonymous with effort syndrome? 212 15

Human herpesvirus-6 (HHV-6), formerly known as human B-lymphotropic virus (HBLV), was first isolated in 1986 from patients with lymphoproliferative disorders and AIDS. Antibody prevalence against HHV-6 varies between about 60-80% indicating a widespread latent infection. Although HHV-6 infects in vivo primarily T-lymphocytes, it is associated with similar diseases as in infection with Epstein-Barr virus (EBV), a clearly B-lymphotropic virus. Reactivation of latent HHV-6 infection in patients with subnormal host defense may cause persistent active infection with so-called postinfectious chronic fatigue syndrome (PICFS) or may contribute to other pathologies such as immune deficiency itself, autoimmune disorders or progressive lymphoproliferation. Coinfection of CD4 cells by HHV-6 and human immunodeficiency virus (HIV 1) in AIDS patients can aggravate HIV-induced acquired immune deficiency. These characteristics of the only recently detected new virus justify further intense investigation.
Pathol Res Pract 1989 Dec
PMID:What's new in human herpesvirus-6? Clinical immunopathology of the HHV-6 infection. 255 96

Twenty-seven adults with a diagnosis of the chronic fatigue syndrome were enrolled in a double-blind, placebo-controlled study of acyclovir therapy. The patients had had debilitating fatigue for an average of 6.8 years, accompanied by persisting antibodies to Epstein-Barr virus early antigens (titers greater than or equal to 1:40) or undetectable levels of antibodies to Epstein-Barr virus nuclear antigens (titers less than 1:2) or both. Each course of treatment consisted of intravenous placebo or acyclovir (500 mg per square meter of body-surface area) administered every eight hours for seven days. The same drug was then given orally for 30 days (acyclovir, 800 mg four times daily). There were six-week observation periods before, between, and after the treatments. Three patients had acyclovir-induced nephrotoxicity and were withdrawn from the study. Of the 24 patients who completed the trial, similar numbers improved with acyclovir therapy and with placebo (11 and 10, respectively). Neither acyclovir treatment nor clinical improvement correlated with alterations in laboratory findings, including titers of antibody to Epstein-Barr virus or levels of circulating immune complexes or of leukocyte 2',5'-oligoadenylate synthetase. Subjective improvement correlated with various measures of mood. We conclude that acyclovir, as used in this study, does not ameliorate the chronic fatigue syndrome. We believe that the clinical improvement observed in most patients reflected either spontaneous remission of the syndrome or a placebo effect.
N Engl J Med 1988 Dec 29
PMID:Acyclovir treatment of the chronic fatigue syndrome. Lack of efficacy in a placebo-controlled trial. 284 17

The myalgic encephalomyelitis syndrome has been described over the past 40 years as a relapsing illness occurring mainly in young females, with the cardinal symptoms of muscle pain and exhaustion. This paper reviews recent studies on the syndrome in the United Kingdom, United States and New Zealand. The possible pathogenesis of the syndrome is discussed, as is the difficulty of managing such patients where no certain aetiology is present. It is suggested that the syndrome should be described as the myalgic exhaustion syndrome.
Fam Pract 1988 Dec
PMID:The myalgic encephalomyelitis syndrome. 285 13

The epidemiology of the post viral fatigue syndrome was studied for the years 1985-86. With a strict definition of the syndrome, it was found that there were many misconceptions about this illness. The sex incidence was nearly equal with a similar pattern of twin peaks at 25-29 years and 40-45 years. At diagnosis, 56% were ill for three to six months and only 9% for more than two years. It is estimated that this syndrome is more common than infectious mononucleosis.
Scott Med J 1988 Dec
PMID:The epidemiology of post viral fatigue syndrome. 285

Chronic Fatigue Syndrome (CFS), previously known as neuroasthenia is often considered to be due to psychiatric causes. Evidence for a possible role for the Epstein-Barr virus in CFS is summarized. A plea is made for physicians to accept CFS as a non-psychiatric chronic illness to encourage further research into a clear definition of the syndrome.
Microbiol Sci 1988 Dec
PMID:Epstein-Barr virus and the chronic fatigue syndrome: a short review. 285 1

We report in this paper that proteins from the surface of ejaculated spermatozoa contain antigenic determinants cross-reacting with a rabbit antiserum raised against native CFS, a protein secreted from the rat seminal vesicle and composed of two subunits, namely RSV IV and RSV V. Conversely, no such proteins could be extracted from cauda epididymal spermatozoa. The cross-reacting proteins derived from the ejaculated spermatozoa were analyzed by SDS-PAGE. An electrophoretic pattern different than that expected for native CFS in denaturing conditions was found. In vitro reconstitution experiments showed that labeled native CFS is able to bind cauda epididymal spermatozoa. The CFS protein recovered from the sperm surface was examined and alterations of its structure were also noted. The sperm-coating abilities of CFS and of its RSV IV subunit are discussed.
Eur J Cell Biol 1988 Dec
PMID:Detection of sperm-coating antigens immunologically related to a seminal protein in rat. 324 84

Epidemiology, clinical features and laboratory results of a nosocomial outbreak of Echovirus 7 infections are described. After the admission of the index case with presumably perinatal infection to the neonatology unit, 3 additional babies from the total of 16 patients on the ward were infected. A 5th baby in another unit was also infected; this baby shared in part the nursing staff with the other group. Clinical symptoms of the infection were fever (5 children), gastrointestinal (5) and neurological symptoms (4), apnea and bradycardia (1), and a fine macular rash (1). Five of the 24 persons of the staff suffered from a febrile gastroenteritis during this period. The virus was isolated from stool swabs, throat swabs, urine, blood and CFS. An augmented percentage of immature neutrophils in the peripheral blood count was the only laboratory value found to be abnormal in all of the children. We measured neutralizing antibodies against this virus in an immunoglobulin preparation for i.v. use (Sandoglobulin), to get information about its prophylactic value in these cases. We could not detect any neutralizing antibodies.
Helv Paediatr Acta 1983 Dec
PMID:[Nosocomial epidemic of echovirus type 7 in a neonatology department]. 666 96

The authors discuss a case of inflammatory breast cancer, treated by interdisciplinary therapy (surgical, radiating immuno and chemo therapy). The immune status was evaluated by the determination of the lymphocytes population, monocytes and granulocytes. This evaluation was made before and after immunotherapy (i.e. subcutaneous administration of IL 2). IL 2 receptors were evaluated too. A daily dose of recombinant IL 2 (18 millions U.I.) was administered for six consecutive days. The follow-up studies showed a clear increase of total T lymphocytes, a normalization of T helper/inducers ratio, an improvement of T cytotoxic/suppressors ratio, an increased level of IL 2 receptors. The induction of mRNA for CM-CMF, G-CFS, IL 3, IL 5, IL 6, was also demonstrated, as well as a plasmatic increase of all the growth factors. A rise in neutrophils and eosinophils was documented. These results allowed the continuation of therapeutic approach with the complex radiation-chemotherapy program.
Minerva Chir 1994 Dec
PMID:[Inflammatory carcinoma of the breast: the immunological findings]. 774 61


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