Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0015674 (
chronic fatigue syndrome
)
2,978
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
A high incidence of severe B-cell immunodeficiency and chronic reactivated Epstein-Barr virus (EBV) infection in patients with
chronic fatigue syndrome
(
CFS
) is reported herein. Of the 58 patients evaluated, 100% had evidence of prior EBV exposure and 72% had evidence for reactivated EBV infection. Notably, 94% of
CFS
patients had B-cell immunodeficiency with a marked depletion of their CD19+IgM+ mature B-lymphocyte population. A remarkable 81% of
CFS
patients experienced subjective improvement of their symptoms after treatment with
folinic acid
(CAS 58-05-9, leucovorin). The findings provide unprecedented evidence that
CFS
frequently is a
folinic acid
responsive clinical entity accompanied by B-cell immunodeficiency and inappropriate antibody responses to EBV.
...
PMID:Clinical activity of folinic acid in patients with chronic fatigue syndrome. 1688 22
