Gene/Protein
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Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
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Target Concepts:
Gene/Protein
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Query: UMLS:C0015674 (
chronic fatigue syndrome
)
2,978
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Chronic fatigue syndrome
is a disorder clinically quite similar to fibromyalgia syndrome, and it is of interest to examine if these two syndromes have pathogenetic as well as clinical features in common. Somatomedin C levels have been found to be lower in patients with fibromyalgia syndrome than in healthy controls. An attractive hypothesis relating sleep disturbance, altered somatotropic neuroendocrine function and fibromyalgia symptoms has been put forward as a plausible pathogenic mechanism for fibromyalgia syndrome. We therefore sought to investigate the level of
somatomedin C
in patients with
chronic fatigue syndrome
. Somatomedin C levels were determined by radioimmunoassay in frozen serum specimens from 49 patients with
CFS
and 30 healthy blood donor control subjects of similar age and gender. Somatomedin C levels were higher in patients with
CFS
than in healthy control subjects (255.3 +/- 68.5 vs 211.9 +/- 76.2, P = 0.01). There was no effect of gender, use of nonsteroidal anti-inflammatory drugs or tricyclic drugs on levels of
somatomedin C
. There was a tendency for
somatomedin C
levels to fall with age. In contrast to patients with fibromyalgia, in whom levels of
somatomedin C
have been found to be reduced, levels in patients with
CFS
were found to be elevated. Thus, despite the clinical similarities between these two conditions, they may be associated with different abnormalities of sleep and/or of the somatotropic neuroendocrine axis.
...
PMID:Somatomedin C (insulin-like growth factor I) levels in patients with chronic fatigue syndrome. 920 51
